Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study

Babió, Nancy; Martínez-González, M Á; Estruch, Ramón; Wärnberǵ, Julia; Recondo, Javier; Ortega‐Calvo, Manuel; Serra-Majem, Lluís; Corella, Dolores; Fitó, Montserrat; Ros, Emilio; Becerra‐Tomás, Nerea; Basora, Josep; Salas‐Salvadó, Jordi

doi:10.1016/j.numecd.2014.10.006

Cited by 72 publications

(54 citation statements)

References 28 publications

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“…Zhang et al performed a longitudinal cohort study to explore the relationship between serum UA levels and MetS in Chinese Han urban male population and found serum UA might occur as an important risk factor of MetS [19]. The same results were found in middle-aged Korean men [20] and European individuals [21]. Hyperuricemic animal model caused by fructose-rich diet could induce the components of MetS [22].…”

Section: Discussionmentioning

confidence: 92%

The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices

Zhu

Cui

Gao

et al. 2017

International Journal of Endocrinology

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Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180 min. Results. AN group had higher serum UA levels than OB group. Circulating UA levels were associated with BMI, dyslipidemia, hypertension, IR, and AN. In logistic regression analyses (multivariable‐adjusted), a high serum UA level was associated with high odds ratios (ORs) (95% confidence interval [CI]) for AN in females (ORs = 3.00 and 95% CI [1.02–8.84]) and males (ORs = 6.07 and 95% CI [2.16–17.06]) in the highest quartile (Q4) of serum UA. Conclusions. Serum UA levels were positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, hyperlipidemia, and AN and may be an important risk factor in the development of AN; further evidences in vitro and in vivo are needed to investigate the direct or indirect relationship.

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Section: Discussionmentioning

confidence: 92%

The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices

Zhu

Cui

Gao

et al. 2017

International Journal of Endocrinology

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“…As we know, there is a sex difference in UA level, women usually have a lower UA level than men. Several previous studies have demonstrated that higher UA levels were significantly related with the development of hypertension and metabolic syndrome in women than those in men202829. This could play a part in the observed sex difference in the relationship between UA and acute ischemic stroke because higher uric acid concentrations are associated with these stroke risk factors, which in turn might offset the potential neuroprotective effects of uric acid.…”

Section: Discussionmentioning

confidence: 93%

Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial

Chen

Zhong

et al. 2016

Sci Rep

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The relationship between serum uric acid (UA) and outcomes after acute ischemic stroke remains debatable in human studies, and the sex effect on this association has yet to be explored. Here, we investigated these associations in a prospective study from the China Antihypertensive Trial in Acute Ischemic Stroke. Baseline UA levels were measured in 3284 acute ischemic stroke patients. Primary outcome was defined as a combination of death and major disability (modified Rankin Scale score ≥3) at 3 months. UA levels were significantly higher in men than women (310.6 ± 96.1 vs 257.5 ± 89.9 μmol/L, P < 0.001). The association between serum UA and the primary outcome was appreciably modified by sex (P-interaction = 0.007). After multivariate adjustment, a high serum UA was associated with a decreased risk of primary outcome in men [odds ratio (OR), 0.63; 95% confidence interval (CI), 0.44–0.91; P-trend = 0.01] but not in women (OR, 1.29; 95% CI, 0.83–2.01; P-trend = 0.15), when two extreme quartiles were compared. Subgroup and sensitivity analyses further confirmed these sex-specific findings. Our study indicated that there was a sex-specific association between serum UA and prognosis of acute ischemic stroke. Elevated serum UA was positively associated with better prognosis in men, but not in women.

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“…Although the results were controversy in the previous literature, accumulating evidences indicated that elevated level of sUA was significantly associated with the development and the adverse outcomes of hypertension and MetS [26–28]. Therefore, it was not surprise results that the remission rates of NAFLD were not different between the groups of lowest and highest quartile of sUA among the NAFLD males with hypertension, or those with higher level of TC and TG.…”

Section: Discussionmentioning

confidence: 93%

Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males

et al. 2016

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Epidemiological studies suggest that higher serum uric acid (sUA) level is significantly associated with nonalcoholic fatty liver disease (NAFLD) development. However, little information is available on the relationships between sUA and NAFLD remission. In the present study, 841 NAFLD males (30–75 years) were recruited from a Chinese prospective cohort study (PMMJS) and followed up for five years. The baseline sUA levels of participants were categorized into four quartiles: 191 μmol/L≤ sUA ≤ 347 μmol/L, 347 μmol/L < sUA ≤ 392 μmol/L, 392 μmol/L < sUA ≤ 441 μmol/L and 441 μmol/L

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Associations between serum uric acid concentrations and metabolic syndrome and its components in the PREDIMED study

Cited by 72 publications

References 28 publications

The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices

The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices

Sex-specific Association Between Uric Acid and Outcomes After Acute Ischemic Stroke: A Prospective Study from CATIS Trial

Associations between Serum Uric Acid and the Remission of Non-Alcoholic Fatty Liver Disease in Chinese Males

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