Associations between sex hormone binding globulin and metabolic syndrome parameters in premenopausal obese women

Akın, Fulya; Baştemir, Mehmet; Alkis, Esma; Kaptanoǧlu, Bünyamin

doi:10.4103/0019-5359.44020

Cited by 19 publications

(13 citation statements)

References 28 publications

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“…This phenomenon suggested that disorder of internal sex hormones might be responsible for the formation of TN. The wave of sex hormone binding globulin (SHBG) might play an important role in this process [29, 30]. Our data indicates that the prevalence of TN in both men and women increases gradually with age, which is consistent with previous studies [31, 32].…”

Section: Discussionsupporting

confidence: 91%

Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study

Yin

Wang

Shao

et al. 2014

International Journal of Endocrinology

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Objective. The association between thyroid nodule (TN) prevalence and metabolic syndrome (MetS) has only rarely been examined in iodine-adequate areas and needs further clarification. We investigated correlations between MetS and TN prevalence in the iodine-adequate area of Hangzhou, China. Material and Method. A cross-sectional study that screened and recruited individuals for cohort research 3 years later. The 13522 subjects (8926 men, 4596 women) were screened in 2009 for all MetS components, thyroid ultrasound (US), and thyroid function. Cohort research recruited 1610 subjects who were screened in both 2009 and 2012, of whom 1061 underwent follow-up research. Results. The prevalence of TN was higher in the MetS (+) group than in the MetS (−) group (χ 2 = 69.63, P < 0.001) and higher in women than in men (χ 2 = 11.65, P = 0.001). Waist circumference (WC) was positively related to the prevalence of TN (OR = 1.022, P < 0.001). Individuals with greater WC in 2009 were more likely to suffer from TN in 2012 (RR = 1.434, P = 0.024). Elevated triglyceride level was a risk factor for developing new TN (RR = 1.001, P = 0.035). Conclusion. Both greater WC and elevated triglycerides are risk factors for new TN in this iodine-adequate area in China.

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Section: Discussionsupporting

confidence: 91%

Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study

Yin

Wang

Shao

et al. 2014

International Journal of Endocrinology

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“…This study also found that the results show strong relationships between SHBG and BFI in obese postmenopausal women with exercise (results not shown). Similar findings were reported by Akin et al, 33 who aimed to determine SHBG concentrations in premenopausal obese women and features of the metabolic syndrome. Their low SHBG group was significantly heavier and had higher BMI values with higher WC than the high SHBG group.…”

Section: Discussionsupporting

confidence: 78%

Effects of Aerobic Exercise Training on Serum Sex Hormone Binding Globulin, Body Fat Index, and Metabolic Syndrome Factors in Obese Postmenopausal Women

Kim

2012

Metabolic Syndrome and Related Disorders

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“…While this study was limited to male participants, a low SHBG has also been shown to be associated with obesity [77], [78], insulin resistance [78], [79], and the metabolic syndrome in women [80]. SHBG is a marker of de novo hepatic lipogenesis in both men and women [81], [82].…”

Section: Discussionmentioning

confidence: 98%

Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men

et al. 2012

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BackgroundSleep restriction is associated with development of metabolic ill-health, and hormonal mechanisms may underlie these effects. The aim of this study was to determine the impact of short term sleep restriction on male health, particularly glucose metabolism, by examining adrenocorticotropic hormone (ACTH), cortisol, glucose, insulin, triglycerides, leptin, testosterone, and sex hormone binding globulin (SHBG).Methodology/Principal FindingsN = 14 healthy men (aged 27.4±3.8, BMI 23.5±2.9) underwent a laboratory-based sleep restriction protocol consisting of 2 baseline nights of 10 h time in bed (TIB) (B1, B2; 22:00–08:00), followed by 5 nights of 4 h TIB (SR1–SR5; 04:00–08:00) and a recovery night of 10 h TIB (R1; 22:00–08:00). Subjects were allowed to move freely inside the laboratory; no strenuous activity was permitted during the study. Food intake was controlled, with subjects consuming an average 2000 kcal/day. Blood was sampled through an indwelling catheter on B1 and SR5, at 09:00 (fasting) and then every 2 hours from 10:00–20:00. On SR5 relative to B1, glucose (F 1,168 = 25.3, p<0.001) and insulin (F 1,168 = 12.2, p<0.001) were increased, triglycerides (F 1,168 = 7.5, p = 0.007) fell and there was no significant change in fasting homeostatic model assessment (HOMA) determined insulin resistance (F 1,168 = 1.3, p = 0.18). Also, cortisol (F 1,168 = 10.2, p = 0.002) and leptin (F 1,168 = 10.7, p = 0.001) increased, sex hormone binding globulin (F 1,167 = 12.1, p<0.001) fell and there were no significant changes in ACTH (F 1,168 = 0.3, p = 0.59) or total testosterone (F 1,168 = 2.8, p = 0.089).Conclusions/SignificanceSleep restriction impaired glucose, but improved lipid metabolism. This was associated with an increase in afternoon cortisol, without significant changes in ACTH, suggesting enhanced adrenal reactivity. Increased cortisol and reduced sex hormone binding globulin (SHBG) are both consistent with development of insulin resistance, although hepatic insulin resistance calculated from fasting HOMA did not change significantly. Short term sleep curtailment leads to changes in glucose metabolism and adrenal reactivity, which when experienced repeatedly may increase the risk for type 2 diabetes.

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Associations between sex hormone binding globulin and metabolic syndrome parameters in premenopausal obese women

Abstract: BACKGROUND AND AIMS:The aim of this study was to determine sex hormone binding globulin (SHBG)

Cited by 19 publications

References 28 publications

Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study

Relationship between the Prevalence of Thyroid Nodules and Metabolic Syndrome in the Iodine-Adequate Area of Hangzhou, China: A Cross-Sectional and Cohort Study

Effects of Aerobic Exercise Training on Serum Sex Hormone Binding Globulin, Body Fat Index, and Metabolic Syndrome Factors in Obese Postmenopausal Women

Impact of Five Nights of Sleep Restriction on Glucose Metabolism, Leptin and Testosterone in Young Adult Men

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