Associations between source-resolved PM2.5 and airway inflammation at urban and rural locations in Beijing

Shang, Jing; Zhang, Yuanxun; Schauer, James J.; Tian, Jingyu; Hua, Jian; Han, Tingting; Fang, Daqing; An, Jian-Xiong

doi:10.1016/j.envint.2020.105635

Cited by 20 publications

(5 citation statements)

References 47 publications

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“…In the multivariate analysis, we found that the PM 2.5 exposures were positively associated with elevated FeNO levels among school children from both areas, suburban and urban. In accordance with previous results, Shang et al [53] reported that the ambient PM 2.5 measured in urban areas has strong association with FeNO levels. Another epidemiological study conducted in Taiyuan City, China also reported that only the concentration of PM 2.5 measured inside the classroom was significantly associated with FeNO levels [54].…”

Section: Discussionsupporting

confidence: 91%

Evaluation of the Relationship between Fractional Exhaled Nitric Oxide (FeNO) with Indoor PM10, PM2.5 and NO2 in Suburban and Urban Schools

Isa

Jalaludin

Elias

et al. 2022

IJERPH

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Numerous epidemiological studies have evaluated the association of fractional exhaled nitric oxide (FeNO) and indoor air pollutants, but limited information available of the risks between schools located in suburban and urban areas. We therefore investigated the association of FeNO levels with indoor particulate matter (PM10 and PM2.5), and nitrogen dioxide (NO2) exposure in suburban and urban school areas. A comparative cross-sectional study was undertaken among secondary school students in eight schools located in the suburban and urban areas in the district of Hulu Langat, Selangor, Malaysia. A total of 470 school children (aged 14 years old) were randomly selected, their FeNO levels were measured, and allergic skin prick tests were conducted. The PM2.5, PM10, NO2, and carbon dioxide (CO2), temperature, and relative humidity were measured inside the classrooms. We found that the median of FeNO in the school children from urban areas (22.0 ppb, IQR = 32.0) were slightly higher as compared to the suburban group (19.5 ppb, IQR = 24.0). After adjustment of potential confounders, the two-level hierarchical multiple logistic regression models showed that the concentrations of PM2.5 were significantly associated with elevated of FeNO (>20 ppb) in school children from suburban (OR = 1.42, 95% CI = 1.17–1.72) and urban (OR = 1.30, 95% CI = 1.10–1.91) areas. Despite the concentrations of NO2 being below the local and international recommendation guidelines, NO2 was found to be significantly associated with the elevated FeNO levels among school children from suburban areas (OR = 1.11, 95% CI = 1.06–1.17). The findings of this study support the evidence of indoor pollutants in the school micro-environment associated with FeNO levels among school children from suburban and urban areas.

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Section: Discussionsupporting

confidence: 91%

Evaluation of the Relationship between Fractional Exhaled Nitric Oxide (FeNO) with Indoor PM10, PM2.5 and NO2 in Suburban and Urban Schools

Isa

Jalaludin

Elias

et al. 2022

IJERPH

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“…To a lesser extent, organic extracts gave the same effect, whereas exposure to water-soluble extracts showed no effect. Several studies have already reported the greater ability of particulate samples to induce an inflammatory response compared to their water-soluble (Shang et al, 2020) or organic extracts (Badran et al, 2020b;. As observed in this work, the literature also reported no inflammatory response following exposure of BEAS-2B cells to water-soluble and/or organic extracts (Chowdhury et al, 2018;Honda et al, 2017).…”

Section: Discussionsupporting

confidence: 78%

Oxidative stress response in pulmonary cells exposed to different fractions of PM2.5-0.3 from urban, traffic and industrial sites

Moufarrej

Verdin

Cazier

et al. 2023

Environmental Research

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“…Affected drevers in our study had significantly less neutrophils in their BALF compared to the control group. This could represent a decreased breed related tendency to airway inflammation, or it may represent a difference in the environmental conditions the dogs were living: The affected drevers lived in the countryside with less air pollution and particles compared to the control dogs mostly living in urban areas [38,39]. Another limitation is, that thoracic radiographs were not obtained during a previous episode of hunting associated respiratory distress in 2/7 affected drevers and therefore it cannot be fully confirmed, that findings indicative of pulmonary edema were present.…”

Section: Discussionmentioning

confidence: 99%

Biophysical properties of alveolar surfactant in drever dogs with hunting associated pulmonary edema

Viitanen,

Gehani,

Tilamaa

et al. 2024

Acta Vet Scand

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Background A syndrome of acute non-cardiogenic pulmonary edema associated with hunting is prevalent in the drever breed, but etiology of this syndrome is currently unknown. Alveolar surfactant has a critical role in preventing alveolar collapse and edema formation. The aim of this study was to investigate, whether the predisposition to hunting associated pulmonary edema in drever dogs is associated with impaired biophysical properties of alveolar surfactant. Seven privately owned drever dogs with recurrent hunting associated pulmonary edema and seven healthy control dogs of other breeds were included in the study. All affected dogs underwent thorough clinical examinations including echocardiography, laryngeal evaluation, bronchoscopy, and bronchoalveolar lavage (BAL) as well as head, neck and thoracic computed tomography imaging to rule out other cardiorespiratory diseases potentially causing the clinical signs. Alveolar surfactant was isolated from frozen, cell-free supernatants of BAL fluid and biophysical analysis of the samples was completed using a constrained sessile drop surfactometer. Statistical comparisons over consecutive compression expansion cycles were performed using repeated measures ANOVA and comparisons of single values between groups were analyzed using T-test. Results There were no significant differences between groups in any of the biophysical outcomes of surfactant analysis. The critical function of surfactant, reducing the surface tension to low values upon compression, was similar between healthy dogs and affected drevers. Conclusions The etiology of hunting associated pulmonary edema in drever dogs is not due to an underlying surfactant dysfunction.

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Associations between source-resolved PM2.5 and airway inflammation at urban and rural locations in Beijing

Cited by 20 publications

References 47 publications

Evaluation of the Relationship between Fractional Exhaled Nitric Oxide (FeNO) with Indoor PM10, PM2.5 and NO2 in Suburban and Urban Schools

Evaluation of the Relationship between Fractional Exhaled Nitric Oxide (FeNO) with Indoor PM10, PM2.5 and NO2 in Suburban and Urban Schools

Oxidative stress response in pulmonary cells exposed to different fractions of PM2.5-0.3 from urban, traffic and industrial sites

Biophysical properties of alveolar surfactant in drever dogs with hunting associated pulmonary edema

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