Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients

Chmielowiec, Jolanta; Chmielowiec, Krzysztof; Suchanecka, Aleksandra; Trybek, Grzegorz; Mroczek, Bożena; Małecka, Iwona; Grzywacz, Anna

doi:10.3390/ijerph15102076

Cited by 19 publications

(16 citation statements)

References 51 publications

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“…Some studies have been carried out associating DAT 3′UTR VNTR polymorphism and neuroticism, and most of them did not find significant results (Chmielowiec et al, 2018;Hünnerkopf, Strobel, Gutknecht, Brocke, & Lesch, 2007;Kazantseva, Gaĭsina, Malykh, & Khusnutdinova, 2009;Kazantseva, Gaysina, Malykh, & Khusnutdinova, 2011). However, a recent meta-analysis has suggested that the dopaminergic system is related to personality trait differences in neuroticism only in contexts where there is a high climatic stress (Fischer et al, 2018).…”

Section: Dopaminergic System and Neuroticismmentioning

confidence: 99%

Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

et al. 2019

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Background Neuroticism is associated with low emotional stability, and it is characterized by a tendency to perceive ordinary situations as threatening and difficult to manage. This personality trait has been associated with psychological distress and predicts some mental disorders. Previous studies have shown that women tend to be more neurotic than men and, in general, females have also a higher incidence of anxious and depressive disorders. Methods We analyzed in a sample of 99 female university students (from 18 to 26 years old) if emotional stability, measured using the Big Five Questionnaire, was linked to polymorphic variants in candidate genes related to dopaminergic and serotonergic systems, and other personality variables. Results We found that emotional stability and its subdimensions are genetically associated with MAOA‐uVNTR polymorphism. Thus, women carriers of the 3‐repeat allele (lower MAO‐A expression) showed higher levels of emotional stability. No associations were found with other polymorphisms analyzed, including COMT Val158Met, 5‐HTTLPR, and DAT 3′UTR VNTR. Furthermore, our results showed a negative correlation between emotional stability and depression, state anxiety, and trait anxiety. In fact, MAOA‐uVNTR and trait anxiety also explained emotional stability and its subdimensions. We also found that other genetic characteristic, phenylthiocarbamide tasting, explained impulsivity, specifically tasters controlled impulses better than nontasters. Conclusion Our results indicate that neuroticism might be regulated by MAOA and could be a common factor between different phenotypes, such as aggressive behaviors or personality disorders, observed in women with higher activity genotype who had been exposed to negative environments during childhood. This study could lead to a better understanding of the basis of emotional stability and could lead to future projects for this purpose.

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Section: Dopaminergic System and Neuroticismmentioning

confidence: 99%

Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

et al. 2019

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“…Their findings provide evidence of the lethal consequences of substance abuse in an unobtrusive manner. Moreover, Chmielowiec et al [46] examined the relationship between the mesolimbic dopamine system and addiction in a group of 299 addicted subjects and another group of 301 non-addict controls by analyzing two polymorphisms in their genes (a variable number of tandem repeats in DRD4 and DAT1), which are mainly responsible for dopaminergic transmission, representing a human reward system that is closely related to substance abuse and misuse. It is clear that research using different methods and designs is useful in fortifying and enhancing currently established concepts and knowledge of substance abuse.…”

Section: Researching Substance Abuse: Methods and Designsmentioning

confidence: 99%

Substance Abuse and Public Health: A Multilevel Perspective and Multiple Responses

Yeung

Tam

2020

IJERPH

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Substance abuse has been a thorny public health concern throughout human history. Manifestly, prevention and treatment are the two main strategies commonly adopted to tackle the problem of substance abuse. They are in fact cross-disciplinary, and they relate to the various domains of heredity, biology, psychology, cognitive science, family, social development and cultural structures. This special issue, “Substance Abuse, Environment and Public Health,” has published empirical studies from different regions and countries globally to enhance the international exchange of latest views and findings on the etiology, processes and influences of substance abuse across different domains, through which a multilevel perspective is considered more helpful for analyzing its complex nature, courses and consequences. This in turn suggests the possible need to employ multiple responses dynamically and integratively in the prevention and treatment of substance abuse.

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“…While van Gestel et al (438) reported an association between DAT1 VNTR polymorphisms and novelty seeking, a personality trait associated with SUDs (439), other studies have failed to replicate this finding (440, 441).…”

Section: The Dopamine Systemmentioning

confidence: 99%

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders

et al. 2019

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Opioid use in the United States has steadily risen since the 1990s, along with staggering increases in addiction and overdose fatalities. With this surge in prescription and illicit opioid abuse, it is paramount to understand the genetic risk factors and neuropsychological effects of opioid use disorder (OUD). Polymorphisms disrupting the opioid and dopamine systems have been associated with increased risk for developing substance use disorders. Molecular imaging studies have revealed how these polymorphisms impact the brain and contribute to cognitive and behavioral differences across individuals. Here, we review the current molecular imaging literature to assess how genetic variations in the opioid and dopamine systems affect function in the brain’s reward, cognition, and stress pathways, potentially resulting in vulnerabilities to OUD. Continued research of the functional consequences of genetic variants and corresponding alterations in neural mechanisms will inform prevention and treatment of OUD.

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Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients

Cited by 19 publications

References 51 publications

Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

Emotional stability is associated with the MAOA promoter uVNTR polymorphism in women

Substance Abuse and Public Health: A Multilevel Perspective and Multiple Responses

Molecular Imaging of Opioid and Dopamine Systems: Insights Into the Pharmacogenetics of Opioid Use Disorders

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