Associations between two common single nucleotide polymorphisms (rs2241766 and rs1501299) of ADIPOQ gene and coronary artery disease in type 2 diabetic patients: a systematic review and meta-analysis

Abstract

ADIPOQ gene polymorphisms were indicated to be associated with coronary artery disease (CAD) in diabetic patients, however, published studies reported inconsistent results. We performed this meta-analysis to reach a more accurate estimation of the relationship between two common ADIPOQ genetic polymorphisms (rs2241766 and rs1501299) and CAD risk in diabetic patients. Eligible studies were retrieved by searching PubMed, Embase, Wangfang, VIP database and China National Knowledge Infrastructure databases. Included and excluded criteria were formulated. The case group was diabetic patients with CAD, and the control group was diabetic subjects without CAD. Summary odds rations (ORs) and 95% confidence intervals (CIs) were used to evaluate ADIPOQ polymorphisms associations with CAD risk in diabetic group. Heterogeneity was evaluated by Q statistic and I2 statistic. A total of twelve published articles, involving 3996 cases and 8876 controls were included in this meta-analysis. The pooled results from rs1501299 polymorphism showed decreased risk in homozygote model (TT VS GG: OR=0.67, 95%CI=0.54-0.83). Heterogeneity was detected in our study. Sensitivity analysis and subgroup analysis were conducted in the meta-analysis. For rs2241766 polymorphism, an increased risk was detected in Caucasian subgroup in heterozygote model (CT VS TT: OR=1.19, 95%CI=1.00-1.42). In genotyping method (PCR-RFLP) subgroup, an increased risk was found in recessive model (GG VS GT+TT: OR=2.05, 95%CI=1.23-3.39). In the sensitivity analysis of rs1501299, decreased risk was detected in allelic model (T VS G: OR=0.86, 95%CI=0.76-0.98) and recessive model (TT VS TG+GG: OR=0.47, 95%CI=0.33-0.67). Publication bias is not observed in our results. Our meta-analysis suggests that the rs1501299 polymorphism may play a protective role in CAD in diabetic patients. The rs2241766 polymorphism is found to be associated with a significant increase in CAD risk in Caucasian and genotyping method (PCR-RFLP) subgroups. Further studies are needed to confirm the prediagnostic effect of the two gene polymorphisms in CAD risk in diabetic patients.

Associations between three common single nucleotide polymorphisms (rs266729, rs2241766, and rs1501299) of ADIPOQ and cardiovascular disease: a meta-analysis

“…Zhang et al reported only the weak protective effect of the rs1501299 variant against CVD in general study subjects [ 50 ]. The meta-analysis by Zhao et al revealed that rs1501299 polymorphism may play a protective role for CAD among patients with T2DM [ 22 ]. In comparison, our results revealed no significant association.…”

“…Adiponectin is encoded by ADIPOQ which is located in chromosome 3q27 [ 21 ], and adiponectin levels are influenced by single-nucleotide polymorphisms (SNPs) in ADIPOQ [ 22 ]. SNPs in ADIPOQ have been found to be associated with CVD [ 23 , 24 ], diabetes [ 25 , 26 ], stroke [ 27 , 28 ], myocardial infarction [ 29 , 30 ], cancer [ 31 , 32 ], kidney disease [ 33 , 34 ], and even gynecological conditions [ 35 , 36 ].…”

Associations of the Polymorphisms in ADIPOQ with Circulating Levels of Adiponectin and Lipids: A Meta-Analysis

“…Kanu et al [14] enrolled 29 studies and 29 021 subjects, and obtained similar finding as previous meta-analyses [12,13], that is, G allele of the rs266729 polymorphism significantly increased the risk of CAD. Several meta-analyses [15][16][17] demonstrated that T allele of the rs1501299 polymorphism is a protective allele for CAD.…”

“…Hou et al [15] enrolled 23 studies and 17 333 subjects, and the result showed that T allele of the rs1501299 polymorphism was significantly associated with reduced risk of CAD in Caucasian population. Zhao et al [16] conducted a meta-analysis in the patients with diabetes mellitus (DM), and found that the CAD risk of the patients with TT genotype of the rs1501299 polymorphism was reduced by about 50 % as compared with that of the G allele carriers. Regarding the rs2241766 polymorphism, Kanu et al [14] conducted a meta-analysis in which 40 studies and 25 548 participants were enrolled and found that the G allele significantly increased the risk of CAD as compared with the T allele, which is consistent with the findings in several other meta-analyses [15,16,18].…”

The Association between Adiponectin Single Nucleotide Polymorphisms and Side Effects of Isotretinoin in Acne Patients

“…e ADIPOQ gene contains a number of SNPs, mostly of unknown functions. Among such SNPs are rs1501299 and rs2241766 that have been shown to be of clinical significance [25][26][27][28]. is includes modulation of disease susceptibility and the clinical outcomes to therapeutic agents [15,26,29,30].…”