Associations of the Polymorphisms in ADIPOQ with Circulating
                    Levels of Adiponectin and Lipids: A Meta-Analysis

Mi, Su; Jia, Aimei; He, Yilan; Song, Yaping

doi:10.1055/a-1543-6362

Cited by 3 publications

(3 citation statements)

References 88 publications

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“…The encoded protein, adiponectin, suppresses hepatic glucose production, enhances insulin sensitization, and improves fatty acid oxidation in skeletal muscle 77 . Polymorphisms of the ADIPOQ gene have been suggested to be associated with metabolic traits including phenotypes related to obesity, insulin resistance, and circulating lipids 78–82 . SNPs at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) were associated with improvement of insulin sensitivity (lower fasting insulin and HOMA‐IR) after bariatric surgery.…”

Section: Discussionmentioning

confidence: 99%

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

van der Meer,

Mohamed,

Monpellier

et al. 2023

Obesity Reviews

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SummaryThe extent to which genetic variations contribute to interindividual differences in weight loss and metabolic outcomes after bariatric surgery is unknown. Identifying genetic variants that impact surgery outcomes may contribute to clinical decision making. This review evaluates current evidence addressing the association of genetic variants with weight loss and changes in metabolic parameters after bariatric surgery. A search was conducted using Medline, Embase, Scopus, Web of Science, and Cochrane Library. Fifty‐two eligible studies were identified. Single nucleotide polymorphisms (SNPs) at ADIPOQ (rs226729, rs1501299, rs3774261, and rs17300539) showed a positive association with postoperative change in measures of glucose homeostasis and lipid profiles (n = 4), but not with weight loss after surgery (n = 6). SNPs at FTO (rs11075986, rs16952482, rs8050136, rs9939609, rs9930506, and rs16945088) (n = 10) and MC4R (rs11152213, rs476828, rs2229616, rs9947255, rs17773430, rs5282087, and rs17782313) (n = 9) were inconsistently associated with weight loss and metabolic improvement. Four studies examining the UCP2 SNP rs660339 reported associations with postsurgical weight loss. In summary, there is limited evidence supporting a role for specific genetic variants in surgical outcomes after bariatric surgery. Most studies have adopted a candidate gene approach, limiting the scope for discovery, suggesting that the absence of compelling evidence is not evidence of absence.

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Section: Discussionmentioning

confidence: 99%

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

van der Meer,

Mohamed,

Monpellier

et al. 2023

Obesity Reviews

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“…Two studies in 2017 [ 41 ] and 2019 [ 42 ] showed that the GG genotype of rs1501299 had low levels of TC. A meta-analysis performed by Su et al [ 43 ] proposed that the T allele carriers of rs1501299 polymorphism had higher levels of HDL-C and adiponectin than GG homozygotes, whereas the G allele carriers of rs2241766 polymorphism had lower levels of HDL-C and adiponectin than TT homozygotes. The above results indicated that the associations between ADIPOQ polymorphisms and lipid levels remain inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Polymorphisms of adiponectin gene and gene–lipid interaction with hypertension risk in Chinese coal miners: A matched case-control study

Bai

et al. 2022

PLoS ONE

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Objective Low serum adiponectin level can predict hypertension development, and adiponectin gene (ADIPOQ) polymorphisms have been reported to be linked with hypertension risk. Whereas, the interaction between ADIPOQ polymorphisms and environmental factors on the susceptibility of hypertension remained unclear. The purpose of this study was to explore the relationship of ADIPOQ polymorphisms with hypertension risk and their interaction with lipid levels in coal miners. Methods A matched case-control study with 296 case-control pairs was performed in a large coal mining group located in North China. The participants were questioned by trained interviewers, and their ADIPOQ genotype and lipid levels were determined. Logistic regression, stratified analysis, and crossover analysis were applied to evaluate the effects of rs2241766, rs1501299, and rs266729 genotypes and gene–lipid interaction on hypertension risk. Results In this matched case-control study, the genotypes of rs2241766 TG+GG, rs1501299 GT+TT, and rs266729 CG+GG were marginally related to hypertension risk. Individuals with high total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) level were susceptible to hypertension (TC: odds ratio [OR] = 1.807, 95% confidence intervals [95%CI] = 1.266–2.581; LDL-C: OR = 1.981, 95%CI = 1.400–2.803; HDL-C: OR = 1.559, 95%CI = 1.093–2.223). Antagonistic interactions were detected between rs2241766 and TC, rs1501299 and TC, rs2241766 and LDL-C, and rs1501299 and HDL-C (rs2241766 and TC: OR = 0.393, 95%CI = 0.191–0.806; rs1501299 and TC: OR = 0.445, 95%CI = 0.216–0.918; rs2241766 and LDL-C: OR = 0.440, 95%CI = 0.221–0.877; rs1501299 and HDL-C: OR = 0.479, 95%CI = 0.237–0.967). Stratified analysis showed that hypertension risk was high for the subjects with rs2241766 TG+GG or rs1501299 GG under the low lipid level but low for those under the high lipid level. In the case group, the TC and LDL-C levels for rs2241766 TG+GG were lower than those for rs2241766 GG, and the TC and HDL-C levels for rs1501299 GT+TT were higher than those for rs1501299 GG. Conclusions Although the effects of ADIPOQ polymorphisms alone were not remarkable, an antagonistic interaction was observed between ADIPOQ polymorphisms and lipid levels.

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“…The top prioritized gene in Caucasians is the adiponectin-encoding gene ADIPOQ , located on chromosome 3q27.3 and spanning 15.8 kb. ADIPOQ is composed of three exons and harbors numerous single nucleotide polymorphisms (SNPs) that have been extensively studied in different populations [ 52 , 53 ], with several of these variants showing associations with alterations in adiponectin levels and metabolic syndrome-related phenotypes [ 33 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 51 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 ]. The intricate effects of adiponectin in the nervous system have raised the hypothesis that functional variants in ADIPOQ could be involved in susceptibility to LOAD.…”

Section: Introductionmentioning

confidence: 99%

Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk

Javor,

Ďurmanová,

Klučková

et al. 2024

Life

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Adiponectin, a hormone secreted by adipose tissue, plays a complex role in regulating metabolic homeostasis and has also garnered attention for its potential involvement in the pathogenesis of late-onset Alzheimer’s disease (LOAD). The objective of this study was to investigate the association of ADIPOQ variants with plasma adiponectin levels and LOAD risk in subjects from the Slovak Caucasian population. For this purpose, 385 LOAD patients and 533 controls without cognitive impairment were recruited and genotyped for a total of eighteen ADIPOQ single nucleotide polymorphisms (SNPs). Both single-locus and haplotype-based logistic regression analyses were employed to assess the association of SNPs with LOAD risk, while linear regression analysis was used to explore their influence on adiponectin levels in LOAD patients. ADIPOQ variants rs822395 and rs2036373 in intron 1 were found to significantly elevate total adiponectin levels after accounting for several potential confounders. Additional SNPs in the 5′ region and intron 1 exhibited a non-significant trend of association with adiponectin. However, none of the ADIPOQ SNPs showed an association with LOAD risk, neither in the whole-group analysis nor in subgroup analyses after stratification for sex or the APOE ε4 allele, a well-established LOAD risk factor. In summary, while adiponectin has emerged as a potential contributor to the development of LOAD, this study did not unveil any significant involvement of its gene variants in susceptibility to the disease.

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Associations of the Polymorphisms in ADIPOQ with Circulating Levels of Adiponectin and Lipids: A Meta-Analysis

Cited by 3 publications

References 88 publications

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Genetic variants associated with weight loss and metabolic outcomes after bariatric surgery: A systematic review

Polymorphisms of adiponectin gene and gene–lipid interaction with hypertension risk in Chinese coal miners: A matched case-control study

Adiponectin Gene Polymorphisms: A Case–Control Study on Their Role in Late-Onset Alzheimer’s Disease Risk

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