Associations between Vitamin D-Binding Protein (DBP) Gene Polymorphism (TAAA)n and Development of Osteoporosis in the Volga-Ural Region of Russia

Abstract

Study of DBP gene (TAAA) n polymorphism in women of postmenopausal age revealed a significantly lower incidence of DBP(*) 10 allele and a higher incidence of DBP(*) 11 allele in Russian women with bone fractures in comparison with the relevant controls (χ(2) = 4.47, p = 0.034 and χ(2) = 4.28, p = 0.038, respectively). Allele DBP(*) 11 is a high risk marker (OR = 1.93; 95%CI 1.06-3.48), while allele DBP(*)10 a marker of low risk of bone fractures (OR = 0.59; 95%CI 0.37-0.94). A trend to a reduction of mineral density of the femoral neck and of the lumbar vertebrae in women with DBP(*) 10(*) 8 genotype of DBP gene polymorphic locus (TAAA) n in comparison with DBP(*) 10(*) 10 and DBP(*) 10(*) 11 genotype carriers is traced.

Insights into the Role of Circadian Rhythms in Bone Metabolism: A Promising Intervention Target?

“…Genotyping based on rs4588 of the GC gene showed that total hip-bone mineral content was associated with GC genotype (p = 0.05, ANCOVA) in boys [ 116 ]. In women of postmenopausal age, DBP ∗ 10 (with 10 repeats of TAAA) is associated with lower incidence of bone fracture compared with relevant controls, while DBP ∗ 11 is related to higher incidence [ 117 ]. Another study showed that DBP ∗ 10 and DBP ∗ 11 are both associated with lower risks of osteoporosis [ 118 ].…”