Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans.

Cook, Travis A. R.; Luczak, Susan E.; Shea, Shoshana H.; Ehlers, Cindy L.; Carr, Lucinda G.; Wall, Tamara L.

doi:10.15288/jsa.2005.66.196

Cited by 51 publications

(43 citation statements)

References 45 publications

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“…50 However, not all studies have found a correlation. 51,52 A greater level of response to alcohol in those with ADH1B*2 has also been observed in some studies, 53,54 but not in others. 55 Another way of considering alcohol use is to examine drinking patterns (frequency, number of drinks per occasion), either in people with alcoholism or in a populationbased sample.…”

Section: Association Of Adh1b and Alcoholismmentioning

confidence: 79%

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Green

Stoler

2007

American Journal of Obstetrics and Gynecology

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Section: Association Of Adh1b and Alcoholismmentioning

confidence: 79%

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Green

Stoler

2007

American Journal of Obstetrics and Gynecology

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“…5 Asians have lower rates of alcohol dependence and lower risk of alcoholism and related problems than non-Asians. 8,9 These findings suggest that this physiological sensitivity to alcohol, exhibited as flushing, serves as a protective factor against excessive drinking. …”

Section: Flushing Reaction and Drinking Patternsmentioning

confidence: 98%

Social Meaning of Alcohol-Related Flushing Among University Students in China

Newman

Jinnai

Zhao

et al. 2011

Asia Pac J Public Health

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This study explored drinking patterns, alcohol-related flushing, and ways students themselves and other people respond to flushing in drinking situations. Of 1080 Chinese undergraduate university students, 725 (67.1%) returned the completed surveys. 80% of the students were drinkers (93% of males and 69% of females); 68% of the drinkers were flushers.Most of the students (59.3%) said flushing had no special meaning, i.e. would ignore flushing; 54% of flushers said they could keep drinking "but less" when they flush; 27% of students said that a flushing person should stop drinking; however, if the flushing person is a girl, 89% of the students said the girl should drink less or stop. If the flushing person was a boy, 61% of students said he should drink less or stop. The data do suggest gender differences in the understanding of and social reaction to alcohol-related flushing, and these differences raise interesting questions as to how flushing acts as a potential protective factor against alcohol misuse.

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“…Reinforcing effects of substances are not only due to drug characteristics. Rather, they result from the interaction between drug-related constructs and individuals' characteristics including genetic and environmental influences (Cook et al, 2005;Ellenbroek et al, 2005;Mulligan et al, 2003;Oslin et al, 2003). After controlling for drug types and gender, two trends for familial associations were found for LOTIR and LOTIP (Tables 4 and 5).…”

Section: Familiality Of Times For Transitionsmentioning

confidence: 98%

“…Part of addictive liability is likely due to an interaction between genotypes and drug characteristics, which generate pleasurable or unpleasant physiological responses (Cook et al, 2005;Mulligan et al, 2003;Oslin et al, 2003), as well as environmental factors that may moderate whether drug consumption is reinforcing (Carroll, France, & Meisch, 1979;Ellenbroek, van der Kam, van der Elst, & Cools, 2005). Clarification of genetic contributions to ontology of addiction could be greatly advanced if the addictive liability of substances could be studied in terms of the contributions of genotypes, other interpersonal characteristics, environmental factors, and the interactions between them.…”

Section: Addictive Liability Of Substances As a Source For Phenotypesmentioning

confidence: 99%

Different lengths of times for progressions in adolescent substance involvement

Ridenour

Lanza

Donny

et al. 2006

Addictive Behaviors

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The present study examined Lengths Of Times for important transitions in substance involvement from Initiation to Regular use (LOTIR), first Problem from drug use (LOTIP), and first experience of Dependence (LOTID) for alcohol, tobacco, cannabis, cocaine, and opiates. Data were from a longitudinal study of 590 children (22.2% female) at different levels of risk for substance use disorders based on their fathers' substance use-related diagnoses. Participants' substance involvement was assessed at four ages: 10-12, and follow-ups at two, five, and eight years later. Results suggested that faster transitions were more due to drug-related constructs (including possible social milieus of different drug classes and interactions between drug class and neurophysiology) than intrapersonal constructs. The shortest transition times (and greatest addictive liabilities) were for opiates followed respectively by cocaine, cannabis, tobacco, and alcohol. Females had shorter transition times, though gender differences were small. Some evidence was found for a familial influence on transition times above what was accounted for by differences between substances.

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Associations of ALDH2 and ADH1B genotypes with response to alcohol in Asian Americans.

Cited by 51 publications

References 45 publications

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Alcohol dehydrogenase 1B genotype and fetal alcohol syndrome: a HuGE minireview

Social Meaning of Alcohol-Related Flushing Among University Students in China

Different lengths of times for progressions in adolescent substance involvement

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