Associations of alveolar bone loss and interleukin-1β levels in one- and two-stage surgical procedures: a randomized prospective trial

Abstract

Within the limitations of the short observational period and small sample size of this study, two-stage implant placement shows comparable clinical outcomes to implants placed using a one-stage placement protocol.

Clinical, radiographic, and biochemical evaluation of two‐piece versus one‐piece single implants with a laser‐microgrooved collar surface after 5 years of functional loading

“…In a previous prospective, randomized controlled study carried out in 40 patients (20 patients received single TP/BL implants and 20 patients received single OP/TL implants, both in mandible), Talo Yildirim et al 14 evaluated the changes in CBL and IL‐1β levels in PICF at the implant sites before loading (T0) and during the third (T1) and sixth (T2) months after loading. Around TP/BL implants between T0 and T2, authors found a significantly higher CBL ( p < 0.05) and higher PICF IL‐1β levels, even if the latter did not show a statistically significant difference ( p > 0.05).…”

“…These data suggest that an inflammatory stimulus could originate at the M/I, and that there could be a causal relationship between the magnitude of alveolar bone loss, and the extent of peri‐implant inflammatory status. The influence of M/I on long‐term implant success has been investigated in many experimental and clinical studies and has been the subject of literature reviews which, however, reported contradictory outcomes 1–7,13–16 . Thus, whether the location of M/I influences the degree of crestal bone resorption and the onset of peri‐implant biological complications over time is still subject of debate.…”

“…The influence of M/I on long-term implant success has been investigated in many experimental and clinical studies and has been the subject of literature reviews which, however, reported contradictory outcomes. [1][2][3][4][5][6][7][13][14][15][16] Thus, whether the location of M/I influences the degree of crestal bone resorption and the onset of peri-implant biological complications over time is still subject of debate.…”

Analysis of Biomarkers and Marginal Bone Loss in Platform-Switched and Nonplatform-Switched Implants: A Randomized Clinical Trial

“…According to the literature, IL-1 β is secreted locally during an inflammatory state, accelerating inflammatory reactions with other factors involved in the immune response [ 28 ]. Furthermore, there is some evidence suggesting that IL-1 β is the main proinflammatory biomarker in active peri-implantitis regions; thus, it can be used as an early indicator of peri-implant disease [ 34 ].…”

“…Before sampling, implant sites were isolated using cotton rolls and air-dried to eliminate salivary contamination. Paper strips (PerioPaper; Oraflow, NY, USA) were placed 2-3 mm into the peri-implant crevice with forceps for 30 seconds at the vestibulo-mesial and vestibulo-distal sites of each implant [ 28 ]. In case of blood contamination, the strip was discarded.…”