Associations of apnea hypopnea index and educational attainments with microvascular complications in patients with T2DM

Du, Chunmin; Cai, He; Dong, Lianqin; Zheng, Silan; Wang, Wengui; Zheng, Caiyu; Wang, Shunhua; Lin, Mingzhu; Yang, Shuyu; Li, Xuejun; Li, Zhibin; Liu, Changqin

doi:10.1007/s12020-020-02192-w

Cited by 10 publications

(8 citation statements)

References 33 publications

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“…Anthropometric measurements were conducted as described in detail previously [19]. Subjects underwent weight, height, and WC measurements by using a calibrated scale after removing shoes and heavy clothes.…”

Section: Anthropometric and Laboratory Measurementsmentioning

confidence: 99%

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Zeng

Huang

et al. 2021

BMC Gastroenterol

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Purpose The aim of the study is to explore the independent association of free triiodothyronine (FT3), free thyroxine (FT4) and thyroid stimulating hormone (TSH) with hepatic steatosis and insulin resistance. Methods A cross-sectional study of 88 overweight/obese adults who underwent anthropometric measurements [BMI, waist circumference (WC) and waist-to-height ratio (WHtR)], hepatic steatosis assessment (FibroScan) and thyroid-related hormones tests was conducted from 2018 to 2020 in Xiamen, China. Results Subjects with increasing tertiles of FT3 showed significantly higher levels of controlled attenuation parameter (CAP) ((295.4 ± 44.1, 290.1 ± 68.2 and 331.7 ± 43.6 (dB/m) for tertile 1–3, respectively, p = 0.007) and fatty liver index (FLI) score (47.7 (33.9–60.8), 61.5 (45.1–88.9) and 90.5 (84.5–94.8), respectively, p < 0.001). FT3 significantly and positively correlated with obesity index (BMI, WC, and WHtR), homeostatic model assessment of insulin resistance (HOMA-IR) and hepatic steatosis (CAP and FLI). Multivariable linear regression analyses with adjustment for potential confounding factors showed FT3 was independently associated with BMI (regression coefficient (β (95%CI): 0.024 (0.004–0.043), p = 0.020), HOMA-IR (β (95%CI): 0.091 (0.007–0.174), p = 0.034), CAP (β (95%CI): 25.45 (2.59–48.31), p = 0.030) and FLI (β (95%CI): 0.121 (0.049–0.194), p = 0.001). Neither FT4 nor TSH was significantly associated with any indicators of obesity, insulin resistance or hepatic steatosis. Conclusions Increased FT3, but not FT4 or TSH, was independently associated with higher risks of hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults. Trial registration Registration is not applicable for our study.

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Section: Anthropometric and Laboratory Measurementsmentioning

confidence: 99%

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Zeng

Huang

et al. 2021

BMC Gastroenterol

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“…Anthropometric measurements including body weight, height, WC, blood pressure (BP), and BMI were described previously [ 15 , 16 ]. BMI was calculated as the weight in kilograms divided by the square of the height in meters.…”

Section: Methodsmentioning

confidence: 99%

Visceral Adipose Tissue Indices Independently Correlated with Obstructive Sleep Apnea in Patients with Type 2 Diabetes

Zheng

Lin

et al. 2022

Journal of Diabetes Research

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Aims. We aimed to explore whether visceral adiposity indices were significantly associated with obstructive sleep apnea (OSA) in type 2 diabetes (T2DM) patients. Methods. 100 patients with T2DM who underwent overnight polysomnography were analyzed in this study. Anthropometric data, lipid profiles, and glycemic parameters were recorded. Body fat percentage (BFP) and visceral adipose tissue area (VAT area) were collected from a whole body scan using dual-energy X-ray absorptiometry (DXA). Multivariate logistic regression analysis was performed to explore the associations of AHI with BFP, VAT area, and CVAI. Results. The prevalence rate of OSA was 80%, and the mean (±SD) of age was 47.0 ± 13.6 years. Apnea-hypopnea index (AHI) was significantly and positively associated with either VAT area ( r = 0.433 , p ≤ 0.001 ) or Chinese visceral adiposity index (CVAI) ( r = 0.355 , p ≤ 0.001 ) but not for BFP ( r = 0.107 , p = 0.294 ). Multivariate logistic regression analyses showed that VAT area and CVAI were significantly associated with increased risk of OSA, and the adjusted ORs were (95% CI) 1.025 (1.003-1.047, p = 0.023 ) and 1.018 (1.002-1.034, p = 0.030 ), respectively. However, there was no significant association between BFP and increased risk of OSA. Conclusions. VAT area and CVAI were independent risk factors of OSA in the patients with T2DM.

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“…During the period from 2013 to 2017, a total of 346 T2DM patients underwent overnight polysomnography (PSG) test had been recruited. Exclusion criteria were described as our previous study [24]. Of 346 patients, 317 patients who had complete data on clinical, PSG, and LAP were left for the present analysis.…”

Section: Study Subjectsmentioning

confidence: 99%

“…Demographic data including body weight, standing height, WC, Hip circumference (HC), and arterial blood pressure were collected as described as our previous report [24]. HbA1c, TG, Total cholesterol (TC), HDLcholesterol (HDL-c), and LDL-cholesterol (LDL-c) measurements have also been detailed described in the previous study [24] [16].…”

Section: Demographic and Biochemical Measurementsmentioning

confidence: 99%

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Lipid accumulation product (LAP) was independently associated with obstructive sleep apnea in patients with type 2 diabetes mellitus

et al. 2020

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Background Lipid accumulation product (LAP) is a new index based on a combination of waist circumference (WC) and serum triglycerides (TG) reflecting lipid accumulation. In this cross-sectional study, we aimed to explore whether LAP was independently associated with obstructive sleep apnea (OSA) in Type 2 diabetes mellitus (T2DM) patients. Methods A cross-sectional study of 317 T2DM patients who underwent overnight polysomnography (PSG) tests was conducted. The clinical data between non-OSA group and OSA group were compared. Multivariable linear regression and multivariable logistic regression analyses were performed to determine associations of LAP, with apnea-hypopnea index (AHI) and OSA. Results Among 317 patients, 219 (69.1%) were men, and the mean ages (±SD) were 51.4 (±13.5) years for men and 54.6 (±15.1) years for women (p = 0.067). The prevalence rates of OSA were 63.0% for men and 68.4% for women (p = 0.357). LAP (log-transformed) was significantly correlated with AHI (log-transformed), with the Pearson’s correlation coefficient of 0.170 (p = 0.002). With adjustment for potential confounding factors, multivariate linear regression analyses showed the association of LAP with AHI was not statistically significant, with the adjusted linear regression coefficients (95% CI) of per SD increase of LAP for AHI (log-transformed) was 0.092 (− 0.011–0.194, p = 0.080). Multivariate logistic regression analyses showed LAP was significantly associated with increased risk of OSA, with the adjusted OR (95%CI) of per SD increase of LAP of 1.639 (1.032–2.604, p = 0.036). However, as constituents of LAP, neither TG nor WC was significantly associated with AHI and OSA. Conclusion LAP was independently associated with OSA and might be used as a potential OSA risk marker in T2DM patients, beyond the general index of obesity.

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Associations of apnea hypopnea index and educational attainments with microvascular complications in patients with T2DM

Cited by 10 publications

References 33 publications

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Independent associations of thyroid-related hormones with hepatic steatosis and insulin resistance in euthyroid overweight/obese Chinese adults

Visceral Adipose Tissue Indices Independently Correlated with Obstructive Sleep Apnea in Patients with Type 2 Diabetes

Lipid accumulation product (LAP) was independently associated with obstructive sleep apnea in patients with type 2 diabetes mellitus

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