Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study

Labayen, Idoia; Moreno, Luís A.; Ruiz, Jonatan R.; Ortega, Francisco B.; Sjöstróm, Michael; Huybrechts, Inge; Gross, Marcela González; Spinneker, André; Henauw, Stefaan De; Μanios, Yannis; Molnár, Denés; Leclercq, Catherine; Gottrand, Frédéric

doi:10.1016/j.atherosclerosis.2011.03.032

Cited by 12 publications

(10 citation statements)

References 42 publications

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“…17,18 Putative mechanisms linking pulse pressure with cardiovascular risk may include endothelial dysfunction and increased adhesion of monocytes to endothelial cells, 19,20 both putatively ameliorated by dietary ω-3 fatty acids, 21 particularly in the setting of dysregulated ω-3 fatty acid metabolism resulting from impaired fetal growth. 22,23 We also found some evidence for increased systolic blood pressure in those with reduced birth weight. Whereas not statistically significant, the magnitude of this increase, 1.1 mm Hg/kg birth weight, is consistent with that previously observed in children, adolescents, and young adults, with the effect size of the association increasing with age.…”

Section: Discussionsupporting

confidence: 56%

High Intake of Dietary Long-Chain ω-3 Fatty Acids Is Associated With Lower Blood Pressure in Children Born With Low Birth Weight

Skilton

Raitakari²,

Celermajer³

2013

Hypertension

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Reduced fetal growth is associated with increased systolic blood pressure. Recently, we found an inverse association between serum ω-3 fatty acids and systolic blood pressure in young adults born with impaired fetal growth. We investigated the associations of dietary intake in childhood of the long-chain ω-3 fatty acids eicosapentaenoic acid and docosahexaenoic acid with blood pressure parameters in children born with reduced birth weight. We analyzed data from 3457 children aged 8 to 15 years participating in the continuous National Health and Nutrition Examination Survey 2003-2004, 2005-2006, and 2007-2008. Dietary intake was assessed by two 24-hour dietary recalls, birth weight by questionnaire, and blood pressure was measured. Systolic blood pressure was 1.1 mm Hg higher in those with reduced (<10th centile) compared with normal birth weight (≥ 10th centile), consistent with previous findings, although not statistically significant (P=0.40); however, pulse pressure was significantly higher in these children (3.4 mm Hg). In the 354 participants with reduced birth weight, when compared with children with the lowest tertile of intake, those who had the highest tertile of dietary eicosapentaenoic acid and docosahexaenoic acid intake had significantly lower systolic blood pressure (-4.9 mm Hg [95% confidence interval, -9.7 to -0.1]) and pulse pressure (-7.7 mm Hg [95% confidence interval, -15.0 to -0.4]). High-dietary intakes of eicosapentaenoic acid and docosahexaenoic acid are associated with lower systolic blood pressure and pulse pressure in children born with reduced birth weight. These data are consistent with the hypothesis that long-chain ω-3 fatty acids reduce blood pressure in those with impaired fetal growth.

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Section: Discussionsupporting

confidence: 56%

High Intake of Dietary Long-Chain ω-3 Fatty Acids Is Associated With Lower Blood Pressure in Children Born With Low Birth Weight

Skilton

Raitakari²,

Celermajer³

2013

Hypertension

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“…the homeostatic control mechanisms and a wide array of genetic, environmental and life-style factors [47]. For example, in the HELENA study it was shown that prenatal nutrition and growth was related with the serum PL EPA and DHA levels in adolescents [7]. Also, Schaeffer et al [8] suggested that 29 % of the variance of serum PL ARA concentrations could be attributed to genetic variants in the FADS gene cluster, encoding D5and D6desaturase.…”

Section: Discussionmentioning

confidence: 99%

“…After an overnight fasting period of at least 10 h venous blood samples were drawn in the morning at school according to a standardized collection protocol [7,29]. Details about the sampling, processing and transportation can be found elsewhere [29].…”

Section: Biochemical Analysesmentioning

confidence: 99%

“…However, apart from the influence of the dietary intake, it is known that the FA concentrations in the human body are determined by several other factors as well, such as genetic background, sex, smoking habits, early nutrition, etc. [3,7]. For example, it has been estimated that 29 % of the variance of ARA in the serum PL and up to 9 % of the variance of linoleic acid (LNA) could be explained by genetic variants in the FADS gene cluster, encoding the D5and D6-desaturase enzymes [8].…”

Section: Introductionmentioning

confidence: 99%

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Dietary Lipid Intake only Partially Influences Variance in Serum Phospholipid Fatty Acid Composition in Adolescents: Impact of Other Dietary Factors

Vyncke

Huybrechts

Winckel

et al. 2014

Lipids

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The present study aimed to assess the correlation between food and fatty acid (FA) intake and the serum phospholipid (PL) FA status in European adolescents and explored the percentage of variation in serum PL FA that could be attributed to dietary habits. Participants included 528 adolescents recruited in the HELENA Study. Dietary intake was assessed by two, self-administered, non-consecutive 24-h recalls. PL FA concentrations were measured in fasting venous serum samples. Reduced rank regressions were applied to examine the combined effect of food intakes. Results indicated that the variance in serum PL FA in adolescents, that could be explained by diet varied from 7.0% for MUFA to 14.2% for n-3FA. The variance in the long-chain n-3FA was mainly explained by fish intake but also by coffee and tea consumption. In conclusion this study indicated that dietary intake influences the serum PL FA status to a limited amount but that also other factors interfere. However, dietary intake is important as it is among those factors that could be modified. Furthermore, the results suggest that the overall dietary habits should be considered instead of only the consumption of single foods or nutrients, as the medium of the food or concomitant intake of foods and nutrients might interact and as such influence absorption or metabolism.

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“…86 A significant association between birth weight and serum levels of eicosapentenoic acid and docosahexenoic acid, which have been associated with cardiometabolic risk, [87][88][89] has recently been described in a large European cohort of adolescents (HELENA study). 90 In this context, early nutrition has been proposed to influence the metabolic risk in later life. Breast milk is rich in LCPUFAs, 91 and breast feeding has been associated with lower risk of developing CMD in adult life.…”

Section: Evidence For Liver Programmingmentioning

confidence: 99%

Effect of intrauterine growth retardation on liver and long-term metabolic risk

Cianfarani

Agostoni

Bedogni³

et al. 2012

Int J Obes

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Intrauterine growth retardation predisposes toward long-term morbidity from type 2 diabetes and cardiovascular disease. To explain this association, the concept of programming was introduced to indicate a process whereby a stimulus or insult at a critical period of development has lasting or lifelong consequences on key endocrine and metabolic pathways. Subtle changes in cell composition of tissues, induced by suboptimal conditions in utero, can influence postnatal physiological functions. There is increasing evidence, suggesting that liver may represent one of the candidate organs targeted by programming, undergoing structural, functional and epigenetic changes following exposure to an unfavorable intrauterine environment. The aim of this review is to provide insights into the molecular mechanisms underlying liver programming that contribute to increase the cardiometabolic risk in subjects with intrauterine growth restriction.

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Associations of birth weight with serum long chain polyunsaturated fatty acids in adolescents; the HELENA study

Cited by 12 publications

References 42 publications

High Intake of Dietary Long-Chain ω-3 Fatty Acids Is Associated With Lower Blood Pressure in Children Born With Low Birth Weight

High Intake of Dietary Long-Chain ω-3 Fatty Acids Is Associated With Lower Blood Pressure in Children Born With Low Birth Weight

Dietary Lipid Intake only Partially Influences Variance in Serum Phospholipid Fatty Acid Composition in Adolescents: Impact of Other Dietary Factors

Effect of intrauterine growth retardation on liver and long-term metabolic risk

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