Associations of cardiorespiratory fitness and parental history of diabetes with risk of type 2 diabetes

Goodrich, Kara; Crowley, Shannon K.; Lee, Duck Chul; Sui, Xuemei; Hooker, Steven P.; Blair, Steven N.

doi:10.1016/j.diabres.2011.10.045

Cited by 16 publications

(18 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A longitudinal study of adults after five and a half years found that parental diabetes was associated with increased risk of T2DM, however greater cardiorespiratory fitness slightly attenuated that risk [25].…”

Section: Discussionmentioning

confidence: 98%

Increased physical activity may be more protective for metabolic syndrome than reduced caloric intake. An analysis of estimated energy balance in U.S. adults: 2007–2010 NHANES

Frugé

Byrd

Fountain

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 98%

Increased physical activity may be more protective for metabolic syndrome than reduced caloric intake. An analysis of estimated energy balance in U.S. adults: 2007–2010 NHANES

Frugé

Byrd

Fountain

et al. 2015

Nutrition, Metabolism and Cardiovascular Diseases

View full text Add to dashboard Cite

“…There have also been reported cases in the American population of increased susceptibility to Type II diabetes due to family history and lack of cardiorespiratory fitness [3]. Although Type II diabetes has been asserted to have a genetic linkage [4], the key here is insulin resistance, which can be exacerbated by lifestyle changes and unhealthy dietary intake [3].…”

Section: Introductionmentioning

confidence: 99%

“…Although Type II diabetes has been asserted to have a genetic linkage [4], the key here is insulin resistance, which can be exacerbated by lifestyle changes and unhealthy dietary intake [3]. DeFronzo [5] states that insulin resistance and Type II diabetes have been linked to clusters of cardiovascular and metabolic disorders including hypertension, obesity, glucose intolerance, dyslipidemia, and endothelial dysfunction.…”

Section: Introductionmentioning

confidence: 99%

Potential Roles ofStevia rebaudianaBertoni in Abrogating Insulin Resistance and Diabetes: A Review

Mohd-Radzman

Ismail

Adam

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Insulin resistance is a key factor in metabolic disorders like hyperglycemia and hyperinsulinemia, which are promoted by obesity and may later lead to Type II diabetes mellitus. In recent years, researchers have identified links between insulin resistance and many noncommunicable illnesses other than diabetes. Hence, studying insulin resistance is of particular importance in unravelling the pathways employed by such diseases. In this review, mechanisms involving free fatty acids, adipocytokines such as TNFα and PPARγ and serine kinases like JNK and IKKβ, asserted to be responsible in the development of insulin resistance, will be discussed. Suggested mechanisms for actions in normal and disrupted states were also visualised in several manually constructed diagrams to capture an overall view of the insulin-signalling pathway and its related components. The underlying constituents of medicinal significance found in the Stevia rebaudiana Bertoni plant (among other plants that potentiate antihyperglycemic activities) were explored in further depth. Understanding these factors and their mechanisms may be essential for comprehending the progression of insulin resistance towards the development of diabetes mellitus.

show abstract

“…While the clustering of obesity and physical inactivity in families may account for some of the risk associated with family history of diabetes, only a small percent of the variance has been explained by lifestyle, anthropomorphic, and genetic risk factors (8). Importantly, the relationship between family history of diabetes and risk for diabetes appears to be modifiable: physical inactivity and obesity, the main targets of diabetes prevention efforts, modify the effects of family history of diabetes (4, 9–12). …”

Section: Introductionmentioning

confidence: 99%

Parental History of Diabetes, Positive Affect, and Diabetes Risk in Adults: Findings from MIDUS

Tsenkova

Karlamangla²,

Ryff

2016

ann. behav. med.

View full text Add to dashboard Cite

Background Family history of diabetes is one of the major risk factors for diabetes but significant variability in this association remains unexplained, suggesting the presence of important effect modifiers. Purpose To our knowledge, no previous work has examined whether psychological factors moderate the degree to which family history of diabetes increases diabetes risk. Methods We investigated the relationships among parental history of diabetes, affective states (positive affect, negative affect, and depressed affect), and diabetes in 978 adults from the MIDUS 2 national sample. Results As expected, parental history of diabetes was associated with an almost threefold increase in diabetes risk. We found a significant interaction between positive affect and parental history of diabetes on diabetes (p=.009): higher positive affect was associated with a statistically significant lower relative risk for diabetes in participants who reported having a parental history of diabetes (RR=.66 per unit increase in positive affect; 95% CI: .47; .93), but it did not influence diabetes risk for participants who reported no parental history of diabetes (p=.34). This pattern persisted after adjusting for an extensive set of health and sociodemographic covariates and was independent of negative and depressed affect. Conclusions These results suggest that psychological well-being may protect individuals at increased risk from developing diabetes. Understanding such interactions between non-modifiable risk factors and modifiable psychological resources is important for delineating biopsychosocial pathways to diabetes and informing theory-based, patient-centered interventions to prevent the development of diabetes.

show abstract

Associations of cardiorespiratory fitness and parental history of diabetes with risk of type 2 diabetes

Cited by 16 publications

References 35 publications

Increased physical activity may be more protective for metabolic syndrome than reduced caloric intake. An analysis of estimated energy balance in U.S. adults: 2007–2010 NHANES

Increased physical activity may be more protective for metabolic syndrome than reduced caloric intake. An analysis of estimated energy balance in U.S. adults: 2007–2010 NHANES

Potential Roles ofStevia rebaudianaBertoni in Abrogating Insulin Resistance and Diabetes: A Review

Parental History of Diabetes, Positive Affect, and Diabetes Risk in Adults: Findings from MIDUS

Contact Info

Product

Resources

About