Associations of circulating and dietary vitamin D with prostate cancer risk: a systematic review and dose–response meta-analysis

Abstract

Published literature provides little evidence to support a major role of vitamin D in preventing prostate cancer or its progression.

Vitamin D and prostate cancer prognosis: a Mendelian randomization study

“…This makes a major causal role of vitamin D in prostate cancer unlikely. Our results are in line with a metaanalysis by Gilbert and co-workers, who did not find a significant association of 25-OH-vitamin D levels with total prostate cancer or aggressive prostate cancer risk [20]. The GC rs2282679 variant was furthermore not associated with breast cancer risk [21] or survival from cutaneous melanoma [22].…”

Distribution of 25-hydroxyvitamin D3 in dried blood spots and implications for its quantitation by tandem mass spectrometry

“…Most importantly, it is increasingly being linked with non-bone related developmental conditions such as schizophrenia [31], multiple sclerosis [32], type 1 diabetes [33], as well as some cancers [34,35]. Therefore, a number of prospective studies have now been undertaken to more closely examine such associations.…”

Vitamin D3 and Beta-carotene Deficiency is Associated with Risk of Esophageal Squamous Cell Carcinoma - Results of a Case-control Study in China

“…However, the results are inconsistent (Gilbert et al, 2011). Bruggemann (Bruggemann et al, 2010) reported that VD3 inhibited cell growth in vitro, but was not effective against tumor cell growth in the in vivo animal models.…”