BACKGROUND
Apart from the controversy of high glycemic index and glycemic load associated with precancerous cervical lesions, few studies have examined the impact of fasting blood glucose levels on HPV multiple infections. In a population of HPV-positive women with high-grade cervical lesions, we conducted the current study to appraisal the relationship between blood glucose levels and multiple HPV infections.
METHODS
The present study was a cross-sectional correlative study. A total of 629 participants with a pathologically confirmed HSIL with HPV infection were included from a hospital in China between 2018-1-1 and 2019-12-31. The target independent variable and the dependent variable were glucose level at baseline and multiplicity of HPV respectively. The ratio (OR) and 95% confidence intervals (95% CIs) for the risk of multiple infections were estimated using logistic regression analysis.
RESULTS
The average age of 560 participants was 44.63 ± 10.61 years old, Result of fully-adjusted binary logistic regression showed glucose was negatively associated with risk of event of multiple infection after adjusting confounders (Odds ratio (OR)=0.84, 95%CI(0.57-1.22). Non-linear relationship was detected between glucose and multiplicity of HPV, with point at 5.4. After adjusting for the full range of variables, the effect sizes and confidence intervals for the left and right sides of the inflection points were 0.379 (0.196, 0.732) and 5.083 (1.592, 16.229), respectively.
CONCLUSION
In this cross-sectional study, both hypoglycemia and hyperglycemia predicted an increased risk of multiple infections, demonstrating a U-shaped association between blood glucose levels and HPV multiple infections.