2014
DOI: 10.7314/apjcp.2014.15.18.7639
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Associations of ERCC4 rs1800067 Polymorphism with Cancer Risk: an Updated Meta-analysis

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Cited by 6 publications
(4 citation statements)
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“…We demonstrate that genotype GA and allele A of ERCC4 rs1800067 is signi cantly associated with decreased risk of gallbladder cancer. Our results agree with previous studies linking the allele A with a signi cantly decreased risk of glioma cancer in the Asian population and lung cancer [17,18]. Recent studies have shown a signi cant association of ERCC4 rs1800067 in glioma, gastrointestinal stromal, cervical and meningioma cancer [6,[19][20][21][22] but it does not show association with other cancers such as head and neck, thyroid, breast, and osteosarcoma [23][24][25][26][27].…”
Section: Discussionsupporting
confidence: 90%
“…We demonstrate that genotype GA and allele A of ERCC4 rs1800067 is signi cantly associated with decreased risk of gallbladder cancer. Our results agree with previous studies linking the allele A with a signi cantly decreased risk of glioma cancer in the Asian population and lung cancer [17,18]. Recent studies have shown a signi cant association of ERCC4 rs1800067 in glioma, gastrointestinal stromal, cervical and meningioma cancer [6,[19][20][21][22] but it does not show association with other cancers such as head and neck, thyroid, breast, and osteosarcoma [23][24][25][26][27].…”
Section: Discussionsupporting
confidence: 90%
“…ERCC4 and ERCC5 were indispensable component members of the NER pathway; numerous studies were conducted to investigate the correlations between the SNPs of ERCC4 or ERCC5 and the risk of cancers. However, most previous meta-analyses focused unilaterally on a single SNP and/or an individual cancer type; furthermore, the conclusions of which were inconsonant, resulting from the related small sample size and diversity of population (22,(36)(37)(38). To the best of our knowledge, the present study was the first work to comprehensively elucidate whether the studied variants of both ERCC4 and ERCC5 were associated with cancer risk and then to evaluate the credibility of significantly epidemiological evidence using the Venice criteria and FPRP tests.…”
Section: Discussionmentioning
confidence: 99%
“…Meta-analyses aiming to explore the relationship between ERCC4 and ERCC5 variants and the kinds of human cancers were continuously published ( 21 , 22 ). However, most of these studies involved a single SNP and/or a single cancer; the conclusions are not always consistent, and the functional mechanisms remain unclear.…”
Section: Introductionmentioning
confidence: 99%
“…Loss of ERCC4 causes systemic accelerated aging (XPE) and neurodegeneration. (Muñoz et al, 2005;Bogliolo et al, 2013;Yuan et al, 2014) Excision repair crosscomplementing rodent repair deficiency, complementation group 5 (ERCC5) Endonuclease involved in single-strand DNA nucleotide excision repair at the 3' end.…”
Section: Predictive Modelingmentioning
confidence: 99%