Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID‐19

Zeng, Hao‐Long; Yang, Qing; Yuan, Peihong; Wang, Xu; Cheng, Liming

doi:10.1096/fj.202002346rr

Cited by 70 publications

(86 citation statements)

References 50 publications

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“…However, the difference in blood Cu concentration in relation to severity of COVID-19 was small, i.e., in the range of 10% only, and again not compatible with a vivid and strong positive acute phase response to the infection. This notion is supported by a relatively unchanged Cu status in COVID-19 during the hospital stay, as observed both in the analysis of full blood in the study from Wuhan [60], and in our present analysis of serum Cu and CP in German patients.…”

Section: Discussionsupporting

confidence: 87%

“…Whether these dynamics constitute a positive and pregnancy-supporting response is unknown at present. A very recent analysis of full blood trace elements in COVID-19 from Wuhan, China, indicated a generally increased Cu status in the more severely diseased patients, without observing a difference in full blood Cu when comparing survivors and nonsurvivors [60]. However, the difference in blood Cu concentration in relation to severity of COVID-19 was small, i.e., in the range of 10% only, and again not compatible with a vivid and strong positive acute phase response to the infection.…”

Section: Discussionmentioning

confidence: 99%

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Relation of Serum Copper Status to Survival in COVID-19

et al. 2021

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The trace element copper (Cu) is part of our nutrition and essentially needed for several cuproenzymes that control redox status and support the immune system. In blood, the ferroxidase ceruloplasmin (CP) accounts for the majority of circulating Cu and serves as transport protein. Both Cu and CP behave as positive, whereas serum selenium (Se) and its transporter selenoprotein P (SELENOP) behave as negative acute phase reactants. In view that coronavirus disease (COVID-19) causes systemic inflammation, we hypothesized that biomarkers of Cu and Se status are regulated inversely, in relation to disease severity and mortality risk. Serum samples from COVID-19 patients were analysed for Cu by total reflection X-ray fluorescence and CP was quantified by a validated sandwich ELISA. The two Cu biomarkers correlated positively in serum from patients with COVID-19 (R = 0.42, p < 0.001). Surviving patients showed higher mean serum Cu and CP concentrations in comparison to non-survivors ([mean+/-SEM], Cu; 1475.9+/-22.7 vs. 1317.9+/-43.9 µg/L; p < 0.001, CP; 547.2.5 +/- 19.5 vs. 438.8+/-32.9 mg/L, p = 0.086). In contrast to expectations, total serum Cu and Se concentrations displayed a positive linear correlation in the patient samples analysed (R = 0.23, p = 0.003). Serum CP and SELENOP levels were not interrelated. Applying receiver operating characteristics (ROC) curve analysis, the combination of Cu and SELENOP with age outperformed other combinations of parameters for predicting risk of death, yielding an AUC of 95.0%. We conclude that the alterations in serum biomarkers of Cu and Se status in COVID-19 are not compatible with a simple acute phase response, and that serum Cu and SELENOP levels contribute to a good prediction of survival. Adjuvant supplementation in patients with diagnostically proven deficits in Cu or Se may positively influence disease course, as both increase in survivors and are of crucial importance for the immune response and antioxidative defence systems.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

Relation of Serum Copper Status to Survival in COVID-19

et al. 2021

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“…Thus, the balance of mineral status in body fluids and exhaled breath of COVID-19 patients might be significantly influenced through a yet-to-be-discovered bioinorganic mechanism. Zeng et al [ 26 , 28 ] applied ICP-MS to determinate various elements, including Mn, Ca, Cr, Mn, Fe, Cu, Zn, As, Cd, Hg, Tl, Pb, and others from COVID-19 and non-severe COVID-19 patients’ body fluids. These studies revealed that significant variations of elements associated with the disease development of COVID-19 can be performed using ICP-MS.…”

Section: Ms-based Multidimensional Breath Analysismentioning

confidence: 99%

Mass Spectrometry-Based Human Breath Analysis: Towards COVID-19 Diagnosis and Research

Yuan

2021

J. Anal. Test.

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COVID-19 is a highly contagious respiratory disease that can be infected through human exhaled breath. Human breath analysis is an attractive strategy for rapid diagnosis of COVID-19 in a non-invasive way by monitoring breath biomarkers. Mass spectrometry (MS)-based approaches offer a promising analytical platform for human breath analysis due to their high speed, specificity, sensitivity, reproducibility, and broad coverage, as well as its versatile coupling methods with different chromatographic separation, and thus can lead to a better understanding of the clinical and biochemical processes of COVID-19. Herein, we try to review the developments and applications of MS-based approaches for multidimensional analysis of COVID-19 breath samples, including metabolites, proteins, microorganisms, and elements. New features of breath sampling and analysis are highlighted. Prospects and challenges on MS-based breath analysis related to COVID-19 diagnosis and study are discussed.

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“…Zeng et al [ 77 ] analyzed over 300 patients and found that severe cases (defined as those having oxygen saturation ≤ 93% at rest, or PaO 2 /FiO 2 ≤ 300 mmHg, or requiring ICU care) showed significant lower levels of magnesium than mild and moderate cases, though all values remained within the reference range. Such difference was found consistently over the clinical course since disease onset.…”

Section: Introductionmentioning

confidence: 99%

The relevance of magnesium homeostasis in COVID-19

Trapani

Rosanoff²,

Baniasadi

et al. 2021

Eur J Nutr

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Purpose In less than one and a half year, the COVID-19 pandemic has nearly brought to a collapse our health care and economic systems. The scientific research community has concentrated all possible efforts to understand the pathogenesis of this complex disease, and several groups have recently emphasized recommendations for nutritional support in COVID-19 patients. In this scoping review, we aim at encouraging a deeper appreciation of magnesium in clinical nutrition, in view of the vital role of magnesium and the numerous links between the pathophysiology of SARS-CoV-2 infection and magnesium-dependent functions. Methods By searching PubMed and Google Scholar from 1990 to date, we review existing evidence from experimental and clinical studies on the role of magnesium in chronic non-communicable diseases and infectious diseases, and we focus on recent reports of alterations of magnesium homeostasis in COVID-19 patients and their association with disease outcomes. Importantly, we conduct a census on ongoing clinical trials specifically dedicated to disclosing the role of magnesium in COVID-19. Results Despite many methodological limitations, existing data seem to corroborate an association between deranged magnesium homeostasis and COVID-19, and call for further and better studies to explore the prophylactic or therapeutic potential of magnesium supplementation. Conclusion We propose to reconsider the relevance of magnesium, frequently overlooked in clinical practice. Therefore, magnesemia should be monitored and, in case of imbalanced magnesium homeostasis, an appropriate nutritional regimen or supplementation might contribute to protect against SARS-CoV-2 infection, reduce severity of COVID-19 symptoms and facilitate the recovery after the acute phase.

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Associations of essential and toxic metals/metalloids in whole blood with both disease severity and mortality in patients with COVID‐19

Cited by 70 publications

References 50 publications

Relation of Serum Copper Status to Survival in COVID-19

Relation of Serum Copper Status to Survival in COVID-19

Mass Spectrometry-Based Human Breath Analysis: Towards COVID-19 Diagnosis and Research

The relevance of magnesium homeostasis in COVID-19

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