Associations of Estrogen Receptor, Progesterone Receptor, Human Epidemic Growth Factor Receptor-2 and Ki-67 with Ultrasound Signs and Prognosis of Breast Cancer Patients

Zhao, Xingjuan; Yang, Xuan; Fu, Lei; Yu, Ke-Da

doi:10.2147/cmar.s276422

Cited by 15 publications

(12 citation statements)

References 25 publications

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“…Similarly, a Ki-67 index > 15 was found to be a marker of poor prognosis in the German cohort. 20 Besides the luminal B subtype, a high Ki-67 index was also associated with poor survival in triple negative patients in the present cohort. On the contrary, no correlation was observed between the effect of a high Ki-67 index with patients belonging to the HER-2 enriched subtype and overall survival.…”

Section: Discussionmentioning

confidence: 59%

“…19 This is supported by the results of a German cohort with a significant correlation between high Ki-67 and high-grade tumors. 20 Furthermore, a high Ki-67 index was established as an independent prognostic as well as predictive marker in the breast cancer cohort, exerting effect on overall survival (OS). Similarly, a Ki-67 index > 15 was found to be a marker of poor prognosis in the German cohort.…”

Section: Discussionmentioning

confidence: 99%

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Comparison of Different Molecular Subtypes with 14% Ki-67 Cut-off Threshold in Breast Cancer Patients of Pakistan- An Indication of Poor Prognosis

et al. 2021

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Background: Ki-67 is a proliferation marker that is used not only to categorize patients in luminal A and B subtypes of breast cancers, but also to determine the aggressiveness of the disease in triple negative and human epidermal growth factor 2 (HER2) over expressed molecular subtypes. The present study was designed to evaluate the role of Ki-67 with cut off value of 14% in molecular subgroups and its association with patient prognosis. Methods: Immunostaining was performed on histopathologically confirmed sections (n = 278) to assess expression of Ki-67, estrogen receptor (ER), progesterone receptor (PR) and HER2. Immunoreactivity of molecules was recorded as percentage scoring. Results: Adopting a cut off value of 14%, Ki-67 was high in 88%of the cases included in the study. High Ki-67 was significantly associated with pathological parameters including histological grade, advanced stage and nodal/distant metastasis. Immunoexpression of ER, PR and HER2 also showed strong correlation with high expression of Ki-67. Based on the St. Gallen classification, the cases were categorized into luminal A (10%) and luminal B (51%), triple negative (20%) and HER2 enriched (18%). Ki-67 index was also significantly high in 98% of HER2 enriched and 95% of TNBC patients. Interestingly, Ki-67 score with cut off value of 14% proved to be significant in deciphering prognosis in luminal patients. Moreover, high expression of Ki-67 also proved to be a marker of poor prognosis, especially in triple negative patients. Conclusion: We suggest that utilization of IHC4 status i.e. ER, PR, HER2 and Ki-67 along with pathological findings and molecular subtyping can considerably affect clinical as well as therapeutic decisions.

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Comparison of Different Molecular Subtypes with 14% Ki-67 Cut-off Threshold in Breast Cancer Patients of Pakistan- An Indication of Poor Prognosis

et al. 2021

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“…Ultrasonography can provide a multidirectional, multi-angle sweep of microcalcified breast cancer lesions; this feature is more widely used in the screening and diagnosis of microcalcifications in breast cancer (16). In addition, ultrasonographic observation of lesion blood flow grading correlated with positive ER expression of the estrogen receptor, which can indirectly indicate the sensitivity of breast cancer to treatment (17,18). However, neurovascular metastases Abbreviations: TCGA, The Cancer Genome Atlas; BRCA, Breast invasive carcinoma; BM, Brain metastasis; nDM-BRCA, BRCA with no distance metastasis; nBM-BRCA, BRCA with non-brain metastasis; TPM, Transcripts per million; DE-mRNAs, Differentially expressed mRNAs; DEGs, Differentially expressed genes; GSEA, Gene Set Enrichment Analysis; KM, Kruskal-Wallis; OS, Overall survival; qRT-PCR, Quantitative Reverse Transcription-PCR.…”

Section: Introductionmentioning

confidence: 99%

“…Ultrasonography can provide a multidirectional, multi-angle sweep of microcalcified breast cancer lesions; this feature is more widely used in the screening and diagnosis of microcalcifications in breast cancer ( 16 ). In addition, ultrasonographic observation of lesion blood flow grading correlated with positive ER expression of the estrogen receptor, which can indirectly indicate the sensitivity of breast cancer to treatment ( 17 , 18 ). However, neurovascular metastases in breast cancer were closely related to gene expression characteristics, and the items examined via breast US imaging alone were biased as they do not adequately reflect this.…”

Section: Introductionmentioning

confidence: 99%

Role of Ultrasound Imaging in the Prediction of TRIM67 in Brain Metastases From Breast Cancer

Xuan

Qin

et al. 2022

Front. Neurol.

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ObjectivesUltrasound (US) imaging is a relatively novel strategy to monitor the activity of the blood–brain barrier, which can facilitate the diagnosis and treatment of neurovascular-related metastatic tumors. The purpose of this study was to investigate the clinical significance of applying a combination of US imaging outcomes and the associated genes. This was performed to construct line drawings to facilitate the prediction of brain metastases arising from breast cancer.MethodsThe RNA transcript data from The Cancer Genome Atlas (TCGA) database was obtained for breast cancer, and the differentially expressed genes (DEGs) associated with tumor and brain tumor metastases were identified. Subsequently, key genes associated with survival prognosis were subsequently identified from the DEGs.ResultsTripartite motif-containing protein 67 (TRIM67) was identified and the differential; in addition, the survival analyses of the TCGA database revealed that it was associated with brain tumor metastases and overall survival prognosis. Applying independent clinical cohort data, US-related features (microcalcification and lymph node metastasis) were associated with breast cancer tumor metastasis. Furthermore, ultrasonographic findings of microcalcifications showed correlations with TRIM67 expression. The study results revealed that six variables [stage, TRIM67, tumor size, regional lymph node staging (N), age, and HER2 status] were suitable predictors of tumor metastasis by applying support vector machine–recursive feature elimination. Among these, US-predicted tumor size correlated with tumor size classification, whereas US-predicted lymph node metastasis correlated with tumor N classification. The TRIM67 upregulation was accompanied by upregulation of the integrated breast cancer pathway; however, it leads to the downregulation of the miRNA targets in ECM and membrane receptors and the miRNAs involved in DNA damage response pathways.ConclusionsThe TRIM67 is a risk factor associated with brain metastases from breast cancer and it is considered a prognostic survival factor. The nomogram constructed from six variables—stage, TRIM67, tumor size, N, age, HER2 status—is an appropriate predictor to estimate the occurrence of breast cancer metastasis.

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“…Several studies have announced that BC is often triggered by an over-expression of biomarkers that are most commonly defined by estrogen-receptor (ER), progesterone receptor (PR), and Human Epidermal growth factor Receptor 2 (HER2) status. Estrogen-receptor and PR markers have been demonstrated to be important prognostic factors for endocrine therapy [ 5 , 6 ], whereas, the HER2 gene facilitates the onset, growth, and metastasis of breast cancer [ 7 ]. There are several factors involved in cancer, containing tumor suppressor oncogenes and genes.…”

Section: Introductionmentioning

confidence: 99%

Association study of Bif-1 gene expression with histopathological characteristics and hormone receptors in breast cancer

Mohammadi¹,

Salimi

Angaji

et al. 2022

BMC Women's Health

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Background Breast cancer is a heterogeneous disease that has various clinical outcomes. Bax-interacting factor-1 (Bif-1) is a member of the endophilin B family that generates the pro-apoptotic BCL2-Associated X (BAX) protein in response to apoptotic signals. Lack of Bif-1 inhibits the intrinsic pathway of apoptosis and enhancements the risk of tumor genesis. The present study aimed to investigate the relationship between hormone receptors (ER, PR, and HER2) status and different levels of Bif-1 gene expression in breast cancer patients. Methods Bif-1 gene expression was evaluated in 50 breast cancer tumors and 50 normal breast mammary tissues using the SYBR Green real-time RT-PCR technique. Multivariate and univariate analyses were used to appraise the relationship between the prognostic significance of the Bif-1 gene using SPSS software. In this study, the Bif-1 was selected as a candidate for a molecular biomarker and its expression status in breast cancer patients with hormone receptors (ER, RR, and HER2) compared to patients without these hormone receptors. Results The study showed that the relative expression of the Bif-1 gene in tissues of patients with hormone receptors in breast cancer compared to those without hormone receptors was not statistically significant. The expression levels of the Bif-1 gene in different groups were evaluated for hormone receptor status. No significant relationship was found between the Bif-1 gene expression and hormone receptors (ER, PR, and HER2) (p > 0.05). Conclusion Bif-1 gene expression may be a useful prognostic marker in breast cancer.

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Associations of Estrogen Receptor, Progesterone Receptor, Human Epidemic Growth Factor Receptor-2 and Ki-67 with Ultrasound Signs and Prognosis of Breast Cancer Patients

Cited by 15 publications

References 25 publications

Comparison of Different Molecular Subtypes with 14% Ki-67 Cut-off Threshold in Breast Cancer Patients of Pakistan- An Indication of Poor Prognosis

Comparison of Different Molecular Subtypes with 14% Ki-67 Cut-off Threshold in Breast Cancer Patients of Pakistan- An Indication of Poor Prognosis

Role of Ultrasound Imaging in the Prediction of TRIM67 in Brain Metastases From Breast Cancer

Association study of Bif-1 gene expression with histopathological characteristics and hormone receptors in breast cancer

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