Associations of gestational and the first year of life exposure to ambient air pollution with childhood eczema in Hubei, China

Deng, Shumin; Huang, Danqin; Wang, Wei; Yan, Hong; Li, Shiyue; Xiang, Hao

doi:10.1007/s11356-019-05633-w

Cited by 17 publications

(15 citation statements)

References 52 publications

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“…The authors showed that the risk of AD would rise with an increase in PM10 and NO 2 exposure during the first trimester (odds ratio [OR] and 95% confidence interval [CI] were 1.219 [1.023‐1.452] per 10 μg/m 3 increase in PM10 and 1.353 [1.027‐1.782] per 10 ppb increase in NO 2 ). Furthermore, A Chinese study in 2019 evaluated the relation between childhood eczema and air pollution exposure during gestation and the first year of life 40 . The outcome analysis indicated that high levels of NO2, PM2.5, and PM10 exposures during the gestational period and the first year of life were significantly associated with a positive increase in risk of childhood eczema 40 …”

Section: Resultsmentioning

confidence: 99%

The impact of air pollution on skin and related disorders: A comprehensive review

Abolhasani

Araghi

Tabary

et al. 2021

Dermatologic Therapy

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As the largest organ in the body, human skin is constantly exposed to harmful compounds existing in the surrounding environment as the first-line barrier. Studies have indicated that exposure to high concentrations of many environmental factors, such as ultraviolet (UV) radiation, outdoor air pollutants, including polycyclic aromatic hydrocarbons (PAHs), volatile organic compounds (VOCs), particulate matter (PM), heavy metals, gaseous pollutants, such as carbon monoxide (CO), nitric oxides (NO x ), sulfur oxide (SO 2 ), ozone (O 3 ), and indoor air pollutants (solid fuels consumption), might interrupt the skin's normal barrier function. Besides, the intensity of the pollutants and the length of exposure might be a contributing factor. Air pollutants are believed to induce or exacerbate a range of skin conditions, such as aging, inflammatory diseases (atopic dermatitis, cellulitis, and psoriasis), acne, hair loss, and even skin cancers (mainly melanoma and Squamous Cell Carcinoma) through various mechanisms. The interaction between pollutants and the skin might differ based on each agent's particular characteristics. Also, damaging the skin barrier seems to be closely related to the increased production of reactive oxygen species (ROS), induction of oxidative stress, activation of aryl hydrocarbon receptor (AhR), and inflammatory cytokines. This article reviews recent studies on the correlation between air pollutants and skin diseases, along with related mechanisms.

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Section: Resultsmentioning

confidence: 99%

The impact of air pollution on skin and related disorders: A comprehensive review

Abolhasani

Araghi

Tabary

et al. 2021

Dermatologic Therapy

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show abstract

“…For instance, birth month was only significant among temperate countries and regions of Japan, 13 Taiwan, 14 and China. 15 The effect of specific air pollutants was most commonly reported as significant in China 16 , 17 , 18 , 19 which has a high air pollution index. The study of specific air pollutants may be further driven by resources such as meteorological stations in monitoring air quality.…”

Section: Resultsmentioning

confidence: 99%

A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia

Chew

2020

World Allergy Organization Journal

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Background Atopic dermatitis (AD) is a chronic, inflammatory skin disorder characterised by intense itch and eczematous lesions. Rising prevalence of AD has been observed worldwide including in Asia. Understanding the risk factors associated with AD may explain its pathogenicity and identify new preventive strategies and treatments. However, AD-associated risk factors and comorbidities specific to Asia have not been systematically reviewed. Methods We performed a systematic review in accordance with the Preferred Reporting Item for Systematic Review and Meta-Analyses (PRISMA) guidelines and summarised epidemiological studies investigating personal, family, and environmental factors and comorbidities associated with AD in Asia. Significant factors were assessed if they can be altered through lifestyle practices and further classified into non-modifiable and modifiable factors. Meta-analysis using the random-effect model was also conducted to provide an overall estimate for several significant factors. Results We identified a total of 162 epidemiological studies conducted in Asia. Among non-modifiable factors, a family history of atopic diseases was the most reported, suggesting the involvement of genetics in AD pathogenesis. Among modifiable factors, the results of meta-analyses revealed maternal smoking as the strongest risk factor with a pooled odds ratio (OR) of 2.95 (95% CI, 2.43–3.60), followed by active smoking (pooled OR, 1.91, 95% CI, 1.41–2.59). Conclusion While a family history may aid clinicians in identifying high-risk individuals, literature has long suggested the importance of gene-environment interaction. This review identified several modifiable factors including medical treatments, indoor and outdoor environmental exposure, and personal and family lifestyle specific to Asia. Based on the meta-analyses performed, prevention strategies against AD may start from changing personal and family lifestyle choices, especially smoking habits.

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“…12 A number of studies from China also support the idea that ambient air pollutants are associated with development of pediatric eczema. Deng et al 13 analyzed data from 3167 3-to 6-year-old children recruited from 12 kindergartens in Hubei, China, comparing the parental report of eczema with NO 2 , PM2.5, and PM10 levels assessed at monitoring stations near these facilities. They found a strong relationship between high levels of NO 2 , PM 2.5 , and PM 10 exposures during gestation and the first year of life and risk of childhood eczema.…”

Section: Pollutant Impacts On Eczema Incidencementioning

confidence: 99%

“…They found a strong relationship between high levels of NO 2 , PM 2.5 , and PM 10 exposures during gestation and the first year of life and risk of childhood eczema. 13 were associated with a risk of eczema with ORs of 1.371 and 1.335, respectively. Genetic variants for a number of inflammatory response mediators, including molecular sensors (eg, CD14, TLR2, TLR4), which modulate response to microbial agents in the environment, agents that neutralize oxidative stress, cellular toxicants produced with xenobiotic pollutant exposure (eg, glutathione-S-transferase variants), and inflammatory cytokines (tumor necrosis factor [TNF]) have been linked with the development or exacerbation of airway allergic disease associated with pollutant exposure.…”

Section: Pollutant Impacts On Eczema Incidencementioning

confidence: 99%

“…Intriguingly, the bacterial airway microbiome also modifies the impact of viruses in asthma. In a recent study of in 413 children (ages[6][7][8][9][10][11][12][13][14][15][16][17] assessing seasonal use of omalizumab to decrease asthma exacerbation in the fall, McCauley et al41 examined the relationship between the nasal microbiome and asthma exacerbation. They observed that bacterial populations dominated by Moraxella were associated with increased risk of disease and eosinophil activation and that when Streptococcus species dominant, increased risk of RV infection occurred.…”

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confidence: 99%

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The “envirome” and what the practitioner needs to know about it

Peden

2019

Annals of Allergy, Asthma & Immunology

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Ambient air pollutant exposure has been associated with development of both asthma and eczema. Mechanistic plausibility for the effect of pollutants on atopy has been shown in sensitization studies with diesel exhaust particles and in epigenetic studies of circulating T cells from children with increased exposure to ambient pollutants. 2. Environmental public policy that reduces pollution has clearly been shown to decrease community risk for asthma and to improve lung function 3. Microbiome studies have shown that colonization with specific microbes is associated with increased asthma risk. Colonizations with Staphylococcus pneumoniae, Moraxella catarrhalis, and Haemophilus influenzae are all associated with increased risk for asthma events. Colonization with other organisms may be protective. 4. Endotoxin exposure in early life is often associated with decreased atopic sensitization, although endotoxin exposure may worsen nonatopic asthma and may augment response to allergens in sensitized individuals. 5. Maternal and perinatal stress, household and neighborhood violence, and poor housing stock all promote development of allergic disease and asthma.

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Associations of gestational and the first year of life exposure to ambient air pollution with childhood eczema in Hubei, China

Cited by 17 publications

References 52 publications

The impact of air pollution on skin and related disorders: A comprehensive review

The impact of air pollution on skin and related disorders: A comprehensive review

A systematic review and meta-analysis of risk factors associated with atopic dermatitis in Asia

The “envirome” and what the practitioner needs to know about it

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