Associations of high sensitivity <scp>C</scp>‐reactive protein levels with the prevalence of asymptomatic intracranial arterial stenosis

Wang, J.; Liu, Y.; Zhang, L.; Li, N.; Wang, C.; Gao, Xiang; Zhou, Yong; Wang, Anxin; Wu, Shouling; Wang, Wenjuan

doi:10.1111/ene.12342

Cited by 25 publications

(21 citation statements)

References 30 publications

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“…Diabetes mellitus was defined by a self-reported history, current treatment with insulin or oral hypoglycemic agents, or a fasting blood glucose concentration ≥7.0mmol/l. Dyslipidemia was defined as a self-reported history, current use of cholesterol lowering medicine, or a total cholesterol level ≥6.22 mmol/l or triglyceride ≥2.26mmol/l or low density lipoprotein ≥4.14mmol/l [12]. …”

Section: Methodsmentioning

confidence: 99%

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Wang

Zhou

et al. 2017

PLoS ONE

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PurposeTo examine whether an abnormally thin retinal nerve fiber layer (RNFL) is associated with cerebrovascular insufficiency.DesignCommunity-based study.MethodsThe Asymptomatic Polyvascular Abnormalities in Community Study included Chinese aged 40+ years and without histories of cerebrovascular incidents or coronary heart disease. Using transcranial Doppler and carotid duplex ultrasound examination, we assessed presence and degree of an intracranial arterial stenosis (ICAS) and extracranial carotid arterial stenosis (ECAS) and we measured the RNFL thickness by spectral-domain optical coherence tomography.ResultsThe study included 3,376 participants with a mean age of 54.3±10.3 years. Thinner RNFL was significantly correlated with a higher prevalence of ECAS (P = 0.035; standardized regression coefficient beta:-0.04; non-standardized regression coefficient B:-0.99; 95% confidence intervals(CI):-1.90,-0.07), after adjusting for age (P<0.001;beta:-0.25;B:-0.26;95%CI:-0.30,-0.22), gender (P = 0.001;beta:-0.07;B:-1.36;95%CI:-2.14,-0.58) and blood concentration of low-density lipoproteins (P = 0.03;beta:0.04;B:0.52;95%CI:0.05,0.98). In a reverse manner, prevalence of ECAS was associated with a thinner RNFL thickness (P = 0.007; odds ratio (OR):0.99; 95%CI:0.98,0.99) after adjusting for older age (P<0.001;OR:1.06;95%CI:10.05,10.7), higher prevalence of ICAS (P = 0.01;OR:1.34;95%CI:1.07,1.69) and higher prevalence of carotid artery plaques (P<0.001;OR:9.18;95%CI:6.93,12.2), and higher blood concentration of total cholesterol (P = 0.03;OR:1.12;95%CI:1.01,1.23). In univariate analysis, an increasing degree of ECAS was significantly correlated with a thinner RNFL.ConclusionsHigher prevalence and degree of ECAS were correlated with thinner RNFL and vice versa. Patients with abnormally thin RNFL without ocular disease may undergo carotid artery examination to detect asymptomatic carotid artery stenosis. Examination of the RNFL is useful for the diagnosis of cerebrovascular disease.

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Section: Methodsmentioning

confidence: 99%

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Wang

Zhou

et al. 2017

PLoS ONE

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“…Carotid atherosclerosis is a primary cause of stroke and disability worldwide 1, 2. Inflammation is an important predictor of carotid atherosclerosis and plays a critical role in the formation and development of plaques and enhancement of the intima media thickness (IMT) 3.…”

Section: Introductionmentioning

confidence: 99%

“…Carotid atherosclerosis is a primary cause of stroke and disability worldwide. 1,2 Inflammation is an important predictor of carotid atherosclerosis and plays a critical role in the formation and development of plaques and enhancement of the intima media thickness (IMT). 3 Many inflammatory biomarkers, including lipoprotein-associated phospholipase A2 (Lp-PLA2), fibrinogen, serum amyloid A (SAA) and interleukin-6 (IL-6), have been approved by the United States Food and Drug Administration (FDA) as predictors of ischemic stroke; additionally, high-sensitivity C-reactive protein (hs-CRP) has been associated with carotid atherosclerosis.…”

Section: Introductionmentioning

confidence: 99%

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Liu

Yao

Wang

et al. 2018

J Cellular Molecular Medi

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High‐sensitivity C‐reactive protein (hs‐CRP) and lipoprotein‐associated phospholipase A2 (Lp‐PLA2) have been reported to be independent predictors of atherosclerosis. However, whether the combination of these two markers can improve the prediction of atherosclerosis is unknown. This study aimed to evaluate the association between combining hs‐CRP and Lp‐PLA2 and predicting carotid atherosclerosis. A total of 1982 participants aged ≥40 years were included in this study. Hs‐CRP and Lp‐PLA2 were measured by a high‐sensitivity nephelometry assay and quantitative sandwich enzyme‐linked immunosorbent assay, respectively. Ultrasonography was performed on the bilateral carotid arteries to evaluate stenosis and plaques. Multivariable logistic regression models were used to analyse the association between the combination of the hs‐CRP and Lp‐PLA2 levels and carotid plaques and stenosis. A total of 1579 (79.7%) and 181 (9.1%) subjects had carotid plaques and carotid stenosis, respectively. The group with high hs‐CRP and Lp‐PLA2 levels had the highest prevalence of carotid plaques (90.6%) and stenosis (20.8%). A significant association was found between high hs‐CRP and Lp‐PLA2 levels and carotid stenosis (adjusted odds ratio [OR]: 2.39; 95% confidence interval [CI]: 1.13‐5.09), but this combination was not associated with carotid plaques (OR: 2.62, 95% CI: 0.93‐7.38). The results suggested that the combination of hs‐CRP and Lp‐PLA2 were better predictors than either protein alone with regard to carotid atherosclerosis.

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“…Hypertension was defined as a systolic blood pressure (SBP) ≥ 140 mmHg or a diastolic blood pressure (DBP) ≥ 90 mmHg, a history of hypertension, or taking antihypertensive drugs [20].…”

Section: Study Design and Populationmentioning

confidence: 99%

Association between H-type hypertension and Cognitive impairment in Kailuan community of China: A cross-sectional study.

Chen

et al. 2019

Preprint

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Background Hypertension (HTN) and hyperhomocysteinemia (HHcy) have been reported to be independent predictors of cognitive impairment. However, the conclusions were inconsistent and few studies had reported the combination prediction of HTN and HHcy for cognitive impairment. Our study aimed to evaluate the association between H-type HTN, HTN and HHcy and the risk of cognitive impairment.Methods We used a cross-sectional study- participants aged over 40 years, which were selected from Kailuan communities in China. Cognitive impairment was determined by MMSE scale (MMSE<24). Multivariable logistic regression was used to analyze the association of H-type HTN and cognitive impairment, and we also made stratification analysis by age of participants.Results A total of 3454 participants were included in our study, and ≥65 years old was 16.79%; the gender of male was 56.77%. The prevalence of cognitive impairment in the H-type HTN (HTN+/HHcy+) group (10.74%) was significantly higher than other three groups (2.92%, 6.42%, 5.86%, respectively). The logistic regression results showed that participants with H-type HTN was positively associated with cognitive impairment risk (OR = 2.57, 95% CI: 1.38-4.80). Similar results were observed in participants stratified by age (65 years) (<65 years old: OR =2.01, 95% CI: 0.87- 4.67 ; ≥65 years old: OR=3.63, 95% CI: 1.32-10.01).Conclusion Our finding indicated that H-type HTN was positively associated with the risk of cognitive impairment, especially in ≥ 65 years old. H-type HTN could be the major intervention measures to decrease the incidence of cognitive impairment as well as the stroke in Health Practice Management.

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Associations of high sensitivity C‐reactive protein levels with the prevalence of asymptomatic intracranial arterial stenosis

Abstract: In this large community-based study, subjects with higher hs-CRP levels showed a mild increase in the prevalence of asymptomatic ICAS, independent of traditional vascular risk factors. hs-CRP is an independent predictor of asymptomatic ICAS and intracranial atherosclerotic burden.

Cited by 25 publications

References 30 publications

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Asymptomatic carotid artery stenosis and retinal nerve fiber layer thickness. A community-based, observational study

Association between high‐sensitivity C‐reactive protein, lipoprotein‐associated phospholipase A2 and carotid atherosclerosis: A cross‐sectional study

Association between H-type hypertension and Cognitive impairment in Kailuan community of China: A cross-sectional study.

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