Associations of HLA class II alleles with pulmonary tuberculosis in Thais

Vejbaesya, Sasijit; Chierakul, Nitipatana; Luangtrakool, Komon; Srinak, Duangporn; Stephens, H. A. F.

doi:10.1046/j.1365-2370.2002.00352.x

Cited by 51 publications

(48 citation statements)

References 12 publications

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“…The MHC class I and class II gene HLA-DRB1*02, DRB1*1501 North Eastern Indian [77] No particular HLA type confirmed South India [78,79] HLA-DR2 Iranian [80] HLA-DRB1*07, DQA1*0101 HLA-DQA1*0301, *0501 Thais [81] HLA-DQB1*0502 DQA1*0601, DQB1*0301…”

Section: Hivmentioning

confidence: 99%

HLA and disease

Ghodke‐Puranik

Joshi

Chopra³

et al. 2005

Eur J Epidemiol

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Association of HLA and diseases is well known. Several population studies are available suggesting evidence of association of HLAs in more than 40 diseases. HLA found across various populations vary widely. Some of the reasons attributed for such variation are occurrence of social stratification based on geography, language and religion, consequences of founder effect, racial admixture or selection pressure due to environmental factors. Hence certain HLA alleles that are predominantly associated with disease susceptibility or resistance in one population may or may not show any association in other populations for the same disease. Despite of these limitations, HLA associations are widely studied across the populations worldwide and are found to be important in prediction of disease susceptibility, resistance and of evolutionary maintenance of genetic diversity. This review consolidates the HLA data on some prominent autoimmune and infectious diseases among various ethnic groups and attempts to pinpoint differences in Indian and other population.

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Section: Hivmentioning

confidence: 99%

HLA and disease

Ghodke‐Puranik

Joshi

Chopra³

et al. 2005

Eur J Epidemiol

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“…However, other studies have reported no association. Yuliwulandari found that DRB1*1202 showed a protective effect against TB in Indonesia (Yuliwulandari et al, 2010), whereas Vejbaesya (Vejbaesya et al, 2002) reported no significant difference in DRB1 alleles between TB patients and controls in Thailand. Another report from Brazil showcased overrepresention of DRB1*04 and under-representation of DRB1*15 in TB patients (Lucena et al, 2010).…”

Section: Introductionmentioning

confidence: 97%

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

Wang²,

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Although a number of studies have reported that human leukocyte antigen (HLA)-DRB1 alleles may be correlated with tuberculosis (TB), most were based on small samples or inconsistent and unclear results. Here, we present a meta-analysis to investigate the relationship between HLA-DRB1 alleles and TB susceptibility. We gathered relevant information from published studies on the association between HLA-DRB1 alleles and TB susceptibility through a systematic research. Data from eligible fifteen studies were included in the meta-analyses. Each dataset was statistically analyzed to evaluate the HLA-DRB1 alleles by calculating the respective odds ratios (ORs) and 95% confidence intervals (CIs). The results revealed that frequencies of two DRB1 alleles were significantly decreased in TB: DRB1*03 (P = 0.016, OR = 0.78, 95%CI = 0.67-0.95) and DRB1*07 (P = 0.017, OR = 0.81, 95%CI = 0.68-0.96). Thus, our data indicate that DRB1*03 and DRB1*07 may provide protective effects against TB susceptibility. However, well-designed studies with large sample sizes are required for better understanding of this association.

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“…In Mexican patients with TB a significant positive association with DQB1*0501 was reported by TeranEscandon et al, 5 whereas in a Thai population DQB1* 0502 was found more frequently in subjects with TB. 6 In Cambodia an association was found between TB and DQB1*0503 but not with DQB1*0501 or DQB1*0601. 7 A negative association between the presence of M tuberculosis and DQB1*0301 in Thai subjects and DQB1*0402 in Mexicans was noted.…”

Section: Discussionmentioning

confidence: 85%

“…1 Since the DR alleles play an important role in the modulation of the immune response, a possible association between DQB alleles and TB has been examined in Asian and American ethnic groups, but the results have been inconsistent. [2][3][4][5][6][7] Despite the rising incidence of TB in Europe, no such analysis has yet been carried out in European white populations. A study was therefore undertaken to evaluate the occurrence of DQB1 alleles in TB patients and healthy controls in the same ethnic group in Poland.…”

mentioning

confidence: 99%

Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report

Dubaniewicz

Moszkowska

Szczerkowska

et al. 2003

Thorax

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Background: The human leucocyte antigen (HLA) system plays an important role in the modulation of the immune response. An association between HLA and pulmonary tuberculosis (TB) has been examined in several populations but the results have been inconsistent. The aim of this study was to evaluate the correlation of DQB1 alleles with TB patients and healthy controls in the same ethnic group in Poland. Method: The DQB1 alleles of 38 patients with TB and 58 healthy university staff volunteers were determined by a PCR-SSP low resolution method. Results: The DQB1*05 allele occurred more frequently (p adjusted for multiple comparison = 0.002, OR = 2.84, 95% CI 1.57 to 5.15) and the DQB1*02 allele occurred less frequently (p = 0.01, OR = 0.39, 95% CI 0.21 to 0.71) in patients with TB than in controls. The occurrence of DQB1*03,*04,*06 alleles was similar in the two populations. Conclusions: The occurrence of specific DQB1 alleles may be linked to susceptibility/resistance to tuberculosis.

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Associations of HLA class II alleles with pulmonary tuberculosis in Thais

Cited by 51 publications

References 12 publications

HLA and disease

HLA and disease

Association between HLA-DRB1 alleles and tuberculosis: a meta-analysis

Analysis of DQB1 allele frequencies in pulmonary tuberculosis: preliminary report

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