Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

Chuang, Li Chung; Hu, Chung-Yi; Chen, Hui Chi; Lin, Pei Jung; Lee, Bor-Heng; Lin, Ching Yu; Pan, Mei Hung; You, San–Lin; Hsieh, Ching-Liang; Chen, Chien Jen

doi:10.1002/cncr.26227

Cited by 14 publications

(11 citation statements)

References 34 publications

(46 reference statements)

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“…We found a decreased risk of CSCC in association with the HLA-DPB1*05:01 allele and +550 G/G genotype and G allele and an increased risk in association with the +550 A allele. When the analysis was restricted to the subgroup of women with HPV-16 positive CSCC, the association of HLA-DPB1*05:01 allele still existed and the DPB1 Certain HLA class II alleles have been reported to influence cervical cancer development by affecting the interactions between host immune response and HPV infection [23][24][25][26]. The DRB1 and DQB1 loci therefore have been thoroughly investigated in several cervical cancer association studies [5].…”

Section: Discussionmentioning

confidence: 99%

Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

Yang

Chang

Chen

et al. 2015

Cancer Immunol Immunother

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Cervical cancer is a multifactorial disease, and increasing evidence suggests that host immunogenetic background may contribute to its pathogenesis. Genetic variations in human leukocyte antigen (HLA) genes may alter the efficiency of immune response to human papillomavirus (HPV) antigens and have been implicated in the risk of cervical cancer. We investigated whether polymorphisms in the HLA-DPB1 gene were associated with cervical cancer risk in a Taiwanese population. HLA-DPB1 alleles and +550 G/A polymorphism were genotyped in a case-control study of 473 women with cervical squamous cell carcinoma (CSCC) and 676 healthy controls. The presence and genotypes of HPV in CSCC were determined. We found that the DPB1*05:01 and +550 A alleles were associated with decreased and increased risk of CSCC, respectively [odds ratio (OR) = 0.72, Pc = 0.001; OR = 1.25, Pc = 0.03]. In subgroup analysis based on HPV type 16 positivity, significant associations were shown in the DPB1*05:01 and *13:01 alleles (OR = 0.65, Pc = 0.0007; OR = 1.83, Pc = 0.004). Furthermore, the DPB1*05:01-G and *13:01-G haplotypes conferred decreased and increased risk of both CSCC and HPV-16 positive CSCC women, respectively (OR = 0.72, Pc = 0.0009; OR = 0.63, Pc = 0.0004 for DPB1*05:01-G; OR = 1.55, Pc = 0.03; OR = 1.84, Pc = 0.004 for DPB1*13:01-G). A risk haplotype DPB1*02:01-A was also observed in the HPV-16 positive CSCC women (OR = 1.51, Pc = 0.05). These findings suggest that HLA-DPB1 gene is involved in the CSCC development.

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Section: Discussionmentioning

confidence: 99%

Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

Yang

Chang

Chen

et al. 2015

Cancer Immunol Immunother

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“…Some HPV studies have reported very powerful associations. For example, a case control study for HPV by Powell et al (2011) reported ORs as high as 2770; Chen et al (2011), as high as 75; Chuang et al (2012), ORs 18.1 and higher; and Almonte et al (2011), ORs of 16.1 [46-49]. …”

Section: Discussionmentioning

confidence: 99%

The association of DNA Repair with breast cancer risk in women. A comparative observational study

et al. 2012

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BackgroundPrevious studies have found a link between a low DNA repair capacity (DRC) level and increased cancer risk. Our aim was to assess the statistical association of DRC level and breast cancer (BC) using a case–control epidemiological study in a Hispanic community.MethodsWe conducted a comparative observational study to assess the validity of DRC in detecting BC in 824 women throughout Puerto Rico. Over a 6-year period, we compared 285 women newly diagnosed with BC to 539 without BC. DRC levels were measured in lymphocytes by means of a host-cell reactivation assay. We assessed the sensitivity, specificity, and association using the receiver operating characteristic curve analysis. Multiple logistic regression-adjusted odds ratios were estimated with 95% confidence level to measure the strength of the association of DRC and BC after adjusting for all confounders simultaneously.ResultsCompared to women without cancer, women with BC showed an average decrease of 60% in their DRC levels (p < 0.001). Validity of the association of DRC as a measure of BC risk showed a sensitivity of 83.2% and specificity of 77.6% (p < 0.0001).ConclusionsOur results support the usefulness of DRC level as a measure of BC risk. Additional studies in other populations are needed to further verify its usefulness.

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“…However, the HLA-A∗02-B∗51 haplotype was associated with resistance to disease. Susceptibility to HPV infection or cervical cancer and precancerous lesion development was associated with the HLA class II: HLA-DRB1 alleles [34, 39–51]; HLA-DQB1 alleles [34, 39, 46, 49–51]; HLA-DPB1 alleles [51]; and classes I and II haplotypes [30, 34, 40–42, 48, 52, 53]. Some alleles and haplotypes had a protective effect against the progression to infection and cancer [34, 38–40, 43, 46, 47, 51, 54, 55].…”

Section: Discussionmentioning

confidence: 99%

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

Marangon

Guelsin

Visentainer

et al. 2013

BioMed Research International

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The genetic variability of the host contributes to the risk of human papillomavirus (HPV)-related cervical disease. Immune response genes to HPV must be investigated to define patients with the highest risk of developing malignant disease. The aim of this study was to investigate the association of polymorphic immune response genes, namely KIR, HLA class I and II, and single-nucleotide polymorphisms (SNPs) of cytokines with HPV-related cervical disease. We selected 79 non-related, admixed Brazilian women from the state of Paraná, southern region of Brazil, who were infected with high carcinogenic risk HPV and present cervical intraepithelial neoplasia grade 3 (CIN3), and 150 HPV-negative women from the same region matched for ethnicity. KIR genes were genotyped using an in-house PCR-SSP. HLA alleles were typed using a reverse sequence-specific oligonucleotide technique. SNPs of TNF −308G>A, IL6 −174G>C, IFNG +874T>A, TGFB1 +869T>C +915G>C, and IL10 −592C>A −819C>T −1082G>A were evaluated using PCR-SSP. The KIR genes were not associated with HPV, although some pairs of i(inhibitory)KIR-ligands occurred more frequently in patients, supporting a role for NK in detrimental chronic inflammatory and carcinogenesis. Some HLA haplotypes were associated with HPV. The associations of INFG and IL10 SNPs potentially reflect impaired or invalid responses in advanced lesions.

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Associations of human leukocyte antigen class II genotypes with human papillomavirus 18 infection and cervical intraepithelial neoplasia risk

Cited by 14 publications

References 34 publications

Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

Genetic susceptibility to cervical squamous cell carcinoma is associated with HLA-DPB1 polymorphisms in Taiwanese women

The association of DNA Repair with breast cancer risk in women. A comparative observational study

The Association of the Immune Response Genes to Human Papillomavirus-Related Cervical Disease in a Brazilian Population

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