Associations of IL-10 genetic polymorphisms with the risk of urologic cancer: a meta-analysis based on 18,415 subjects

Abstract

BackgroundInterleukin-10 (IL-10) is a powerful modulator of anti-tumor immune responses. The IL-10 promoter region polymorphisms are known to regulate IL-10 production, and thus are thought to be implicated in tumorigenesis. Recently, the roles of these polymorphisms in urologic cancer have been extensively studied, with conflicting results. Therefore, we conducted the present meta-analysis to better elucidate the correlations between IL-10 polymorphisms and urologic cancer risk.MethodsEligible articles were searched in PubMed, Medline, Embase, Scopus and CNKI up to May 2016. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to detect any potential associations between IL-10 polymorphisms and the risk of urologic cancer.ResultsA total of 22 case–control studies including 8572 patients and 9843 controls were analyzed. The overall meta-analysis results showed that IL-10 −592C>A polymorphism was significantly associated with urologic cancer in CA versus AA (P = 0.04, OR 0.87, 95% CI 0.76–0.99) and AA versus CC+CA (P = 0.03, OR 1.15, 95% CI 1.02–1.31). Subgroup analyses by cancer types suggested there were significant associations between all the three investigated IL-10 polymorphisms and bladder cancer. However, subgroup analyses by ethnicity only detected a weak association between IL-10 −819C>T and Asian population.ConclusionsOur findings suggests that IL-10 −592C>A polymorphism may implicate with urologic cancer risk. Besides, promoter region polymorphisms of IL-10 may serve as potential biological markers, especially for bladder cancer. Furthermore, IL-10 −819C>T polymorphism may contribute to urologic cancer susceptibility in Asians while all the three studied variants of IL-10 did not relate to Caucasian urologic cancer predisposition.

Genetic Polymorphisms Involved in Bladder Cancer: A Global Review

“…Other interleukins that play a role in macrophages and neutrophils' immunosuppressive roles include IL-10, IL-12, and IL-23 [95]. Rs1800896, rs1800871, and rs1800872 in IL-10 [96] are associated with an increased risk for BC in Chinese [97] and Indian [98] populations; rs10889677 in IL-23R also increases BC risk in Chinese [99] and Polish [92] populations; and IL-12 decreases the risk in the Indian population [93]. Other interleukins were also found to play a role in BC risk; for instance, rs2069762 in the IL-2 gene increases the risk for BC in the Chinese population.…”

High level of interleukin-10 in serum after therapy is characteristic of prostate carcinoma patients with high Gleason score, high tumor volume and present peritumoral infiltration

“…Generally, the results of IL-10 polymorphysm studies are still confusing, ranging from no significant association 17,18,19,20,21,22,23,24 to association of particular alleles in CP patients 15,25,26,27,28,29,30,31,32,33,34,35,36 . Several of these studies that confirmed association of particular IL-10 polymorphism with CP reported also a significant correlation of GG-1082 gene alleles with low grade tumors 18,26,28,32,34,37 , absence of bone metastasis 30 or low reccurence rate 31 .…”