Associations of Leg Length, Trunk Length, and Total Adult Height With Ménière’s

Tyrrell, Jessica; Taylor, Mark; Whinney, David; Osborne, Nicholas J.

doi:10.1097/aud.0000000000000132

Cited by 3 publications

(3 citation statements)

References 35 publications

(52 reference statements)

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“…However, inconsistent with the previous study, height was not significantly different between the two groups in this study. This may be due to the self-reported diagnosis of MD in the previous study 8 or racial differences.…”

Section: Discussionmentioning

confidence: 88%

“…A previous UK study reported that tall stature and high leg length are associated with the prevalence of MD, suggesting that early life environmental exposures may influence skeletal growth and onset of MD 8 . However, inconsistent with the previous study, height was not significantly different between the two groups in this study.…”

Section: Discussionmentioning

confidence: 96%

“…MD is a complex heterogeneous disorder, with multiple factors reported to contribute to its development, 4 including age (older than 60 years), sex (female) 2 , 3 , genetics 5 , 6 , race (white people) 7 , stature and leg length (short) 8 , metabolic disorder 9 , 10 , autoimmunity 10 – 17 , anatomy 18 , allergies 19 , migraines 20 , weather (high humidity and low atmospheric pressure) 21 , diets, and stress 22 . However, the majority of studies are limited by a lack of population-based cohorts and low number of cases; therefore, the underlying disease pathological pathways remain unclear.…”

Section: Introductionmentioning

confidence: 99%

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Population-based study for the comorbidities and associated factors in Ménière’s disease

Kim

2022

Sci Rep

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To date, no study has reported the objective metabolic laboratory findings worldwide or the comorbidities for Ménière’s disease (MD) using a population-based design in Asian populations. The aim of this study was to investigate the comorbidities and associated factors for MD using the Korean National Health Insurance Service database. This retrospective population-based study was conducted using a data from the National Sample Cohort database from 2009 to 2015. We only enrolled patients whose records showed a prescription for MD medicine and audiometry findings as well as an appropriate diagnostic code. We also included a matched cohort without MD who were enrolled randomly and matched for sex, age, year of diagnosis, income level, and residential area with the MD group with a ratio of 10:1. We evaluated comorbidities including autoimmune, allergic, metabolic diseases and cancer and the health screening data including general characteristics (height, weight, waist circumference, body mass index, and blood pressure), laboratory findings (fasting glucose, cholesterol, triglyceride, high-density lipoproteintryglyceride (HDL) cholesterol, low-density lipoproteintryglyceride cholesterol, hemoglobin, creatinine, aspartate aminotransferase and alanine aminotransferase, and gamma-glutamyltrans- peptidase (rGT)), and general health behaviors (smoking, alcohol, and exercise) of the MD group, and compared these characteristics with those of the MD-free control group. A total of 2,013 and 20,130 participants were included in the MD and MD-free control groups (1,640 and 15,458 for health screening data). We found the increase in incidence of allergic rhinitis and allergic asthma, decrease in systolic blood pressure, HDL cholesterol, and rGT, and less frequent alcohol consumption and less prevalent smoking in the MD group. No significant differences were observed between the groups in the incidence of autoimmune diseases, and cerebro- and cardiovascular disease as well as health screening data and objective laboratory findings. Inconsistence with published studies, the results of this study suggest that the autoimmunity and metabolic disorder, and skeletal growth might not be associated with the onset of MD. Another well-designed study for other races will be needed to the generalization of this study results.

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Section: Discussionmentioning

confidence: 88%

Section: Discussionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Population-based study for the comorbidities and associated factors in Ménière’s disease

Kim

2022

Sci Rep

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Human tissue banking and its role in biomedical research

Mian¹,

Ashankyty²

2016

Applied Molecular Biotechnology

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Diagnosis of Menière’s disease according to the criteria of 2015: Characteristics and challenges in 96 patients

Ihler

Stoycheva

Spiegel

et al. 2022

VES

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BACKGROUND: The diagnosis of Menière’s disease (MD) is made according to diagnostic criteria, the last revision of which was in 2015. For diagnosis, symptoms are weighted with audiometric findings and this can be challenging in individual patients. OBJECTIVE: To analyze patient’s characteristics and symptoms in a real-life cohort of 96 patients with diagnosed MD regarding sociodemographic parameters, clinical specifics, and audiometry. METHODS: Prospective clinical patient registry containing demographic and socioeconomic parameters, symptoms, as well as pure-tone audiometry data. RESULTS: 31 patients with definite MD, and 36 with probable MD were identified. 29 patients showed typical clinical signs of MD, but did not meet the full diagnostic criteria, and were considered separately. Mean duration of symptoms prior to presentation was 3.9±4.6 years. Significant differences between categories were found regarding aural fullness, tinnitus, and fluctuating hearing. If multiple audiograms were available, 28.6 %(6/21) documented fluctuating hearing. CONCLUSIONS: Current diagnostic criteria probably do not represent patients with monosymptomatic presentation or an early stage very well. Long-term follow-up with repeated audiometry is advisable.

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Associations of Leg Length, Trunk Length, and Total Adult Height With Ménière’s

Abstract: The specific association between leg length, a potential marker of adverse childhood environments, and Ménière's may suggest that early-life environmental exposures that influence skeletal growth may also influence the risk of developing Ménière's in later life.

Cited by 3 publications

References 35 publications

Population-based study for the comorbidities and associated factors in Ménière’s disease

Population-based study for the comorbidities and associated factors in Ménière’s disease

Human tissue banking and its role in biomedical research

Diagnosis of Menière’s disease according to the criteria of 2015: Characteristics and challenges in 96 patients

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