Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand

Naksen, Warangkana; Prapamontol, Tippawan; Mangklabruks, Ampica; Chantara, Somporn; Thavornyutikarn, Prasak; Srinual, Niphan; Panuwet, Parinya; Ryan, P. Barry; Riederer, Anne M.; Barr, Dana Boyd

doi:10.1016/j.envres.2015.06.035

Cited by 61 publications

(53 citation statements)

References 59 publications

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“…Paraoxonase ( PON1 ) is known to detoxify organophosphate (OP) pesticides [ 17 ], and depending on the gene polymorphism, can modify the effects of OP exposure [ 18 ]. Two specific PON1 polymorphisms ( − 108 and 192 ) have been implicated as potential modifiers of the association between OP pesticide exposure and poor birth and childhood health outcomes, including reduced birth weight, shortened length of gestation, and neurobehavioral issues [ 19 , 20 , 21 , 22 ]. Other studies have investigated the link between diet and asthma exacerbation.…”

Section: Introductionmentioning

confidence: 99%

Gestational Pesticide Exposure and Child Respiratory Health

Gilden

Friedmann

Holmes

et al. 2020

IJERPH

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Background: Childhood wheeze may be related to pesticide exposure, and diet and genetics (Paroxonase; PON1) may modify the effects of exposure. Methods: We analyzed data from the HOME Study, a prospective pregnancy and birth cohort, to examine the association of gestational urinary organophosphate (OP) and pyrethroid (3PBA) metabolite concentrations with child wheeze, forced expiratory volume in one second (FEV1) at ages 4 and 5 years, and wheeze trajectory patterns through age 8 years. Results: Among 367 singletons, the frequency of wheeze ranged from 10.6% to 24.1% at each measurement age. OP and 3PBA metabolite concentrations were not associated with wheeze at 8 years or from birth to 8 years, but there were three significant interactions: (1) maternal daily fruit and vegetable consumption (less than daily consumption and increasing 3PBA was associated with wheeze at age 8 years, OR = 1.40), (2) maternal PON1-108 allele (CT/TT genotypes and high DE was associated with wheeze at age 8 years, OR = 2.13, 2.74) and (3) PON1192 alleles (QR/RR genotypes with higher diethylphosphate (DE) and dialkyl phosphate (DAP) were associated with wheeze at age 8 years, OR = 3.84). Pesticide metabolites were not consistently related to FEV1 or wheeze trajectory. Conclusions: Gestational OP and 3PBA metabolites were associated with child respiratory outcomes in participants with maternal dietary and genetic susceptibility.

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Section: Introductionmentioning

confidence: 99%

Gestational Pesticide Exposure and Child Respiratory Health

Gilden

Friedmann

Holmes

et al. 2020

IJERPH

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“…HDL also carries paroxonase. As with apoA‐I, lower paroxonase activity has been associated with adverse pregnancy outcomes (48). HDL also transports cholesterol between tissues and can result in removal of cholesterol from membranes or in deposition of cholesterol into cells leading to changes in membrane‐based signaling [reviewed by Fielding and Fielding (49)].…”

Section: Discussionmentioning

confidence: 99%

Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth

Rebholz¹,

Melchior²,

Davidson³

et al. 2018

FASEB j.

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Studies in humans have shown a direct association between maternal plasma cholesterol concentrations and infant birthweight. Similarly, previous studies in our laboratory have shown that chow-fed mice lacking apolipoprotein (apo) A-I, the major protein in HDL, have low HDL-cholesterol (HDL-C) concentrations and smaller fetuses in midgestation. In the current study, we measured fetal weights in mice with varying levels of apoA-I gene dose (knockout, wild-type, and transgenic) and examined metabolic pathways known to affect fetal growth. As expected, we found the differences in apoA-I expression led to changes in HDL particle size and protein cargo as well as plasma cholesterol concentrations. Fetal masses correlated directly with maternal plasma cholesterol and apoA-I concentrations, but placental masses and histology did not differ between groups of mice. There was no significant difference in glucose or amino acid transport to the fetus or in expression levels of the glucose (glucose transporter 1 and 2) or amino acid (sodium-coupled neutral amino acid transporter 1 and 2) transporters in whole placentas, although there was a trend for greater uptake of both nutrients in the whole fetal unit (fetus + placenta) of mice with greater apoA-I levels; significant differences in transport rates occurred when mice without apoA-I (knockout) vs. mice with apoA-I (wild-type and transgenic) were compared. Glucose tolerance tests were improved in the mice with the highest level of apoA-I, suggesting increased insulin-induced uptake of glucose by tissues of apoA-I transgenic mice. Thus, maternal HDL is associated with fetal growth, an effect that is likely mediated by plasma cholesterol or other HDL-cargo, including apolipoproteins or complement system proteins. A direct role of enhanced glucose and/or amino acid transport cannot be excluded.-Rebholz, S. L., Melchior, J. T., Davidson, W. S., Jones, H. N., Welge, J. A., Prentice, A. M., Moore, S. E., Woollett, L. A. Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth.

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“…Reiss [80] found out that the critical exposure period to PO insecticides for human neurological development is, by definition, the only relevant exposure for birth outcomes. Naksen et al [81] reported that the birth outcomes as a result of OP exposure suggest a decrease in birth weight and head circumference in newborns born from mothers with low PONI activity.…”

Section: Organochlorine Pesticides (Ocps)mentioning

confidence: 99%

Pesticides, Anthropogenic Activities, and the Health of Our Environment Safety

AL-Ahmadi¹

2019

Pesticides - Use and Misuse and Their Impact in the Environment

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Mankind depends on agricultural products for food consumption. Increasing population (more than 7 billion) requires significant growth in crop yield to meet essential demand. This aim was achieved through the use of pesticides to protect crops from diseases. Pesticides are toxic by design for organisms that can threaten food products. Their mode of action is by targeting systems or enzymes in the pests that may be similar to human system and therefore pose risks to human health and the environment as well. The WHO recommended classifying pesticides according to their toxicity and chemicals according to their chronic health and environmental hazards.

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Associations of maternal organophosphate pesticide exposure and PON1 activity with birth outcomes in SAWASDEE birth cohort, Thailand

Cited by 61 publications

References 59 publications

Gestational Pesticide Exposure and Child Respiratory Health

Gestational Pesticide Exposure and Child Respiratory Health

Studies in genetically modified mice implicate maternal HDL as a mediator of fetal growth

Pesticides, Anthropogenic Activities, and the Health of Our Environment Safety

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