Associations of metabolic factors, especially serum retinol-binding protein 4 (RBP4), with blood pressure in Japanese -the Tanno and Sobetsu study-

Chiba, M; Saitoh, Shigeyuki; Ohnishi, Hirofumi; Akasaka, Hiroshi; Mitsumata, Kaneto; Furukawa, Tetsuaki; Shimamoto, Kazuaki

doi:10.1507/endocrj.k10e-054

Cited by 23 publications

(18 citation statements)

References 34 publications

(36 reference statements)

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“…Given that adipokine expression may be affected by sex hormones, a study reported that increases in RBP4 levels following blood pressure increases exclusively occurs in women and not men [9]. We compared serum RBP4 levels between genders, but no sex difference was observed.…”

Section: Discussionmentioning

confidence: 98%

Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients

Deng

Zhang

Zheng

et al. 2014

Diabetol Metab Syndr

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BackgroundInsulin resistance (IR) is closely correlated with cardiovascular disease (CVD). Retinol-binding protein 4 (RBP4) is a novel adipokine that modulates the action of insulin in various diseases. This study addressed the relationship between RBP4 and IR in newly diagnosed essential hypertension.MethodsSerum RBP4, anthropometric and metabolic parameters were determined in 267 newly diagnosed essential hypertensive patients not taking antihypertensive medications. The patients along with 64 control (NC) normotensive and lean subjects paired by age and sex were divided into two groups depending on body mass index (BMI), hypertension with obesity (HPO) and hypertension without obesity (HP).ResultsA striking difference was observed in RBP4 levels between the HP and NC groups. Significantly higher levels were noted in the HP group compared with the NC group; slightly, but not significantly, lower levels were observed in the HPO group compared with the HP group. After adjusting for BMI, WC and WHR, a modestly linear relationship was observed between RBP4 levels and SBP (r = 0.377; p = 0.00), DBP (r = 0.288; p = 0.00) and HOMA-β(r = 0.121; p = 0.028). Multiple stepwise regression analysis showed that SBP, WHR and drinking were independently related with serum RBP4 levels.ConclusionsThe results of this study indicated that RBP4 levels were increased in naive hypertensive patients; however, no differences were observed in obese or non-obese hypertensive subjects. Our data suggest for the first time that RBP4 levels are significantly increased but do not contribute to the development of IR in newly diagnosed hypertensive Chinese patients.

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Section: Discussionmentioning

confidence: 98%

Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients

Deng

Zhang

Zheng

et al. 2014

Diabetol Metab Syndr

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“…A growing body of evidence suggested that higher circulating concentrations of RBP4 were closely associated with obesity and advanced age [11,14,15,46]. Moreover, several studies showed serum RBP4 levels were increased and positively correlated with body mass index (BMI) in obese non-diabetic and diabetic subjects [47][48][49]. Prior studies indicated that higher pre-pregnancy maternal BMI and advanced maternal age were associated with increased risk for GDM [50,51].…”

Section: Discussionmentioning

confidence: 99%

Circulating retinol-binding protein 4 levels in gestational diabetes mellitus: a meta-analysis of observational studies

Huang

Luo

et al. 2015

Gynecological Endocrinology

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Retinol-binding protein 4 (RBP4) is a novel adipocyte-derived cytokine playing an important role in the regulation of energy metabolism and insulin sensitivity. Although the association between RBP4 and metabolic dysfunction is well established, studies on the relationship between circulating RBP4 levels and the risk of gestational diabetes mellitus (GDM) have yielded inconclusive results. We performed a meta-analysis to investigate whether women with GDM had higher circulating RBP4 levels than the normglycemic pregnant women. PubMed, Web of Science and EMBASE were searched up to 1 August 2014. A total of 14 studies comprised of 884 women with GDM and 1251 normglycemic pregnant women were included. The overall results suggested that maternal circulating RBP4 levels were significantly higher in GDM than their normal controls (SMD: 0.49 μg/ml, 95% CI: 0.23-0.75 μg/ml, p < 0.001, random effect model). However, stratified results indicated that this significant difference only existed in the second/third trimester and was limited to Asian populations. Furthermore, subgroup analysis according to matched maternal age and BMI still demonstrated that GDM had higher circulating RBP4 levels than the normal controls. Our findings suggested that Asian women with GDM had increased circulating RBP4 levels in their second/third trimester.

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“…The peripheral vascular resistance is increased by adipocytokines (e.g. leptin, TNF-a, RBP4) [32][33][34]. The study has several strengths.…”

Section: Discussionmentioning

confidence: 99%

Impact of obesity on incident hypertension independent of weight gain among nonhypertensive Japanese

Tsujimoto¹,

Sairenchi²,

Iso³

et al. 2012

Journal of Hypertension

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Associations of metabolic factors, especially serum retinol-binding protein 4 (RBP4), with blood pressure in Japanese -the Tanno and Sobetsu study-

Cited by 23 publications

References 34 publications

Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients

Serum retinol-binding protein 4 levels are elevated but do not contribute to insulin resistance in newly diagnosed Chinese hypertensive patients

Circulating retinol-binding protein 4 levels in gestational diabetes mellitus: a meta-analysis of observational studies

Impact of obesity on incident hypertension independent of weight gain among nonhypertensive Japanese

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