Associations of Muscle Size and Density With Proximal Femur Bone in a Community Dwelling Older Population

Lu, Yin; Xu, Zhengyang; Wang, Ling; Li, Wei; Zhao, Yue; Su, Yongbin; Sun, Wei; Liu, Yandong; Yang, Minghui; Yu, Aihong; Blake, Glen M.; Wu, Xinbao; Veldhuis-Vlug, Annegreet; Cheng, Xiaoguang; Hind, Karen; Engelke, Klaus

doi:10.3389/fendo.2020.00503

Cited by 22 publications

(18 citation statements)

References 30 publications

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“…The present results showed that the PDFFs of several muscles were negatively associated with the aBMD of subregions of the proximal femur as follows: the G.MaxM was negatively associated with the aBMD of the FN, TR, and IT; the G.MedM was negatively associated with the aBMD of the TR and IT; and the IliopM was negatively associated with the aBMD of the FN, TR, and IT. Lu ( 32 ) found that the lipid infiltration of the G.MaxM and mid-thigh muscle is associated with the aBMD of the proximal femur, which agreed with the present study. Intramuscular fat infiltration impairs the ability of the skeletal muscle to produce normal protein, resulting in decreased insulin sensitivity.…”

Section: Discussionsupporting

confidence: 92%

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Wang

Zhang

et al. 2022

Front. Endocrinol.

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PurposeTo investigate the relationship of muscle atrophy and fat infiltration around the hip joint with areal bone mineral density (aBMD) in each subregion of the proximal femur.Materials and methodsIn total, 144 participants (66 women and 78 men) were examined by quantitative computed tomography (QCT), and areal bone mineral density (aBMD) of the femoral neck (FN), trochanter (TR), and intertrochanter (IT) of the proximal femur were obtained. The cross-sectional area (CSA) and proton density fat fraction (PDFF) of the gluteus maximus (G.MaxM), gluteus medius (G.MedM), gluteus minimus (G.MinM), and iliopsoas (IliopM) were obtained via magnetic resonance imaging (MRI) using the mDIXON-Quant sequence. A multivariate generalized linear model was used to evaluate the correlation of the CSA and PDFF of muscles with aBMD in all subregions of the proximal femur.ResultsThe FN integral (Int) aBMD was significantly associated with the G.MaxM CSA (men: P = 0.002; women: P = 0.008) and PDFF (men: P < 0.001; women: P = 0.047). Some muscle indexes were related to the FN aBMD in males or females, including the CSA of G.MedM, G.MinM, and IliopM as well as the PDFF of IliopM and G.MinM. Associations of hip muscle parameters with the TR Int aBMD in both males and females were observed, including G.MaxM CSA (men: P < 0.001; women: P = 0.028) and G.MaxM PDFF (men: P = 0.031; women: P = 0.038). Other muscle indexes, including G.MedM and IliopM, were related to the TR aBMD, mainly affecting the aBMD of TR cortical (Cort) and TR Int. The IT Int aBMD and IT Cort aBMD showed significant correlation with the muscle indexes of G. MaxM, IliopM, and G.MedM, including the PDFF and CSA in males and females. Further, more indicators of the G.MedM and IliopM correlated with the TR and IT aBMD compared to the FN aBMD.ConclusionsThe CSA of gluteus muscles and iliopsoas had a positive association with the aBMD in the proximal femur, and the PDFF of gluteus muscles and iliopsoas had a negative correlation with the aBMD in the proximal femur. In addition, there was an interaction of the proximal femur aBMD with the muscle size and fatty infiltration of hip muscles.

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Section: Discussionsupporting

confidence: 92%

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Wang

Zhang

et al. 2022

Front. Endocrinol.

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“…This finding is relevant because as IMAT increases, muscle quality, and possibly muscle function, decreases ( 43 ). Moreover, the frequently occurring low muscle mass at legs level and reduced thigh cross-sectional muscle area are known to be associated with reduced bone mineral densities, in line with a previous report ( 44 ), underscoring the relationship between bone and skeletal muscle in elderly osteoporotic women.…”

Section: Discussionsupporting

confidence: 88%

Circulating Carboxylated Osteocalcin Correlates With Skeletal Muscle Mass and Risk of Fall in Postmenopausal Osteoporotic Women

et al. 2021

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BackgroundBone and skeletal muscle represent a single functional unit. We cross-sectionally investigated body composition, risk of fall and circulating osteocalcin (OC) isoforms in osteoporotic postmenopausal women to test the hypothesis of an involvement of OC in the bone-muscle crosstalk.Materials and MethodsTwenty-nine non-diabetic, non-obese, postmenopausal osteoporotic women (age 72.4 ± 6.8 years; BMI 23.0 ± 3.3 kg/m2) underwent to: 1) fasting blood sampling for biochemical and hormone assays, including carboxylated (cOC) and uncarboxylated (uOC) osteocalcin; 2) whole-body dual energy X-ray absorptiometry (DXA) to assess total and regional body composition; 3) magnetic resonance imaging to determine cross-sectional muscle area (CSA) and intermuscular adipose tissue (IMAT) of thigh muscles; 4) risk of fall assessment through the OAK system.ResultsAppendicular skeletal muscle index (ASMMI) was low in 45% of patients. Forty percent got a low OAK score, consistent with moderate-severe risk of fall, which was predicted by low legs lean mass and increased total fat mass. Circulating cOC levels showed significantly correlated with βCTx-I, lean mass parameters including IMAT, and OAK score. Fractured and unfractured women did not differ for any of the analyzed parameters, though cOC and uOC positively correlated with legs lean mass, OAK score and bone markers only in fractured women.ConclusionsData supported the relationship between OC and skeletal muscle mass and function in postmenopausal osteoporotic women. Serum cOC, but not uOC, emerges as mediator in the bone-muscle crosstalk. Circulating cOC and uOC levels may be differentially regulated in fractured and unfractured osteoporotic women, suggesting underlying differences in bone metabolism.

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“…Participants were anthropometrically measured in age of 31 and 46, and what is more in age of 46 their body composition was measured and lumbar MRI was performed to calculate surface area of lumbar vertebrae. Results suggest that from anthropometric measures, height and lean body mass have the most notorious correlation with surface area of vertebrae [15]. In Beijing Jishuitan Hospital relationship between Bone Mineral Density of femur, lumbar vertebrae and iliac bone and density of surrounding muscles was verified using CT in group of women.…”

Section: Muscle Mass and Fracturesmentioning

confidence: 92%

Impact of physical activity on incidence of osteoporotic fractures - a review

Oszczędłowski

Niewęgłowski

Madoń

et al. 2021

J Educ Health Sport

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Introduction and purpose: The purpose od this study is to describe influence of participating in sporting activities on health of the bones. Osteoporosis is a disease of elderly people in which bone mineral density lowers. Physical activity was reported to increase bone mineral density.A brief description of the state of knowledge: Better physical performance is a positive factor that lowers the possibility of fracturing the bones of the elderly. Another factor that plays protective role is lean body mass and development of muscles. Training in young age can help to increase the bone mineral density, but the effect ceases with the passing of time, being much lower after decades. Multiple genes have impact on bone mineral density of the individual. Professional athletes have usually higher bone mineral density, but accumulation of microdamage in their bones can result in stress fractures. Training in elderly age is proven to increase bone mineral density of an individual, especially performing weight-bearing sports.Conclusions: Physical activity has been proven to positively affect health in many ways. One of them is strengthening the bones by increasing bone mineral density. As it increases, the possibility to break the bone lowers, which makes it an effective way to support the fight against the osteoporosis. It is especially important for women, who are more susceptible to osteoporotic fractures in post-menopausal age.

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Associations of Muscle Size and Density With Proximal Femur Bone in a Community Dwelling Older Population

Abstract: Conclusions: We observed positive associations of the gluteus and thigh muscle size with proximal femur volumetric BMD. Specifically, the gluteus maximus muscle CSA was associated with trochanter cortical vBMD in both men and women.

Cited by 22 publications

References 30 publications

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Associations of muscle size and fatty infiltration with bone mineral density of the proximal femur bone

Circulating Carboxylated Osteocalcin Correlates With Skeletal Muscle Mass and Risk of Fall in Postmenopausal Osteoporotic Women

Impact of physical activity on incidence of osteoporotic fractures - a review

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