Associations of myeloperoxidase, interleukin-17A and heparin-binding EGF-like growth factor levels with in-stent restenosis after percutaneous coronary intervention: a single-centre case–control study in China

Abstract

ObjectivesTo investigate the changes in serum myeloperoxidase (MPO), interleukin (IL)-17A and heparin-binding EGF-like growth factor (HB-EGF) levels before and after percutaneous coronary intervention (PCI), and to evaluate the associations of MPO, IL-17A and HB-EGF levels with the 1-year restenosis rate.DesignCase–control study.SettingsXiangyang Central Hospital between January 2012 and December 2017.ParticipantsPatients with coronary heart disease who underwent PCI.InterventionsNot applicable.Primary and secondary outcome measuresNot applicable.ResultsFinally, 407 and 132 patients were included in the control and in-stent restenosis (ISR) groups, respectively. The general clinical characteristics of the patients were not significantly different between the two groups. The MPO, IL-17A and HB-EGF levels were not significantly different between the two groups at baseline but significantly increased after PCI. The ISR group showed higher levels of MPO, IL-17A and HB-EGF compared with the control group at all postoperative time points. Multivariable analysis showed that MPO, IL-17A and HB-EGF were associated with increased ISR [MPO (OR=1.003; 95% CI: 1.001 to 1.005; p=0.002), IL-17A (OR=1.015; 95% CI: 1.009 to 1.020; p<0.0001) and HB-EGF (OR=2.256; 95% CI: 1.103 to 4.009; p=0.002)]. All three factors had sensitivity and specificity ≥68% for ISR.ConclusionsHB-EGF could be used for the detection of ISR after PCI and could be of use for the prediction of ISR, but the value of MPO and IL-17A might be more limited. This will have to be validated in future studies.

[Retracted] Predictive Value of Perioperative Cytokine Levels on the Risk for In‐Stent Restenosis in Acute Myocardial Infarction Patients

“…These previous results revealed the role of CRP and TNF- α levels in predicting the risk of in-stent restenosis. However, Jiang et al [ 16 ] observed inflammatory factors at different time points during the perioperative period and found that serum hs-CRP and TNF- α increased 24 hours after coronary stent placement, but there was no obvious correlation with vascular restenosis within 6 months after surgery. This was also shown in this study, which may be caused by mechanical damage during stent placement, hypoxia, and the continuous extension of the stent to the vessel wall.…”

The effect of Huoxue Huayu decoction on restenosis after percutaneous coronary intervention in patients with coronary heart disease

“…PCI is the main treatment for CHD. [ 3 , 4 ] However, post-PCI restenosis remains a challenging clinical problem. [ 5 , 6 ] Restenosis is defined as a lumen occlusion of more than 50%.…”

Predictive value of LncRNA on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

“…[ 1 ] Percutaneous coronary intervention is an effective technique for clinical treatment of coronary heart disease, and can greatly improve the survival rate of patients with coronary heart disease. [ 2 , 3 ] However, the problem of in-stent restenosis seriously influences the effect of percutaneous coronary intervention, which still perplexes clinical workers. [ 4 ] More than 98% non-protein coding RNA and nucleotides in human genome are long-stranded non-coding RNA (LncRNA) with more than 200 nucleotides that can regulate myocardial hypertrophy, myocardial fibrosis and cardiomyocyte apoptosis.…”