Predictive value of LncRNA on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

Sheng-xiang, Liu; Yang, Guangyao; Huang, Yupeng; Zhang, Cheng; Huang, Jin

doi:10.1097/md.0000000000024114

Cited by 6 publications

(5 citation statements)

References 16 publications

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“…As the leading cause of non-infection disease deaths worldwide, CHD has become an increasing and un-negligible public health problem. [ 1 , 23 , 24 ] Preliminary risk stratification can provide better prevention and management of CHD. Novel biomarkers, such as elevated TG/HDL-C ratio, were reported to be associated with a higher risk of atherosclerotic CHD.…”

Section: Discussionmentioning

confidence: 99%

Is elevated triglyceride/high-density lipoprotein cholesterol ratio associated with poor prognosis of coronary heart disease? A meta-analysis of prospective studies

et al. 2022

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Background: Elevated triglycerides (TG) and reduced high-density lipoprotein cholesterol (HDL-C) are recognized as essential and independent hazard factors for total death and major adverse cardiovascular events (MACE) in patients with coronary heart disease (CHD). However, whether the increased TG/HDL-C forecasted the prognosis of CHD is still unknown. Therefore, we performed a meta-analysis to investigate the relationship between the elevated TG/HDL-C ratio and poor prognosis of CHD. Methods: A systematic literature search was conducted in PubMed, Web of Science, EMBASE, and The Cochrane Library, until August 30, 2021. Prospective observational studies regarding the association between TG/HDL-C and long-term mortality/MACEs in CHD patients were included. Results: In total, 6 independent prospective studies of 10,222 participants with CHD were enrolled in the systematic and meta-analysis. Our outcomes of the meta-analysis indicated that the elevated TG/HDL-C group had a significantly increased risk of long-term all-cause mortality (hazard ratio [HR] = 2.92, 95% confidence interval [CI]: 1.75–4.86, P < .05) and long-term MACEs (HR = 1.56, 95%CI 1.11–2.18, P < .05). Conclusion: In patients with CHD, the present study showed that the high TG/HDL-C was associated with increased risk of long-term all-cause mortality and MACE.

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Section: Discussionmentioning

confidence: 99%

Is elevated triglyceride/high-density lipoprotein cholesterol ratio associated with poor prognosis of coronary heart disease? A meta-analysis of prospective studies

et al. 2022

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“…[75][76][77] Clinically, intervention therapies, such as percutaneous coronary intervention, are usually utilized for treating the vascular narrowing. 78,79 However, such therapies are faced with the problem of limited transplantation sources. In this regard, vascular grafts based on engineered biomaterials have been extensively investigated and developed to replace the autografts.…”

Section: Vascular Repairmentioning

confidence: 99%

Emerging technologies for cardiac tissue engineering and artificial hearts

Sun

Wang

et al. 2023

Smart Medicine

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Heart diseases, especially cardiovascular diseases, have brought heavy burden on society for their high morbidity and mortality. In clinical, heart transplantation is recognized as an effective strategy to rescue the lives of patients, while it may suffer from lack of donors and possible immune responses. In view of this, tremendous efforts have been devoted to developing alternative strategies to recover the function and promote the regeneration of cardiac tissues. As an emerging field blending cell biology and material science, tissue engineering technique allows the construction of biomimetic living complexes as organ substitutes for heart repair. In this review, we will present the recent progress in cardiac tissue engineering and artificial hearts. After introducing the critical elements in cardiac tissue engineering, we will present advanced fabrication methods to achieve scaffolds with desired micro/nanostructure design as well as the applications of these bioinspired scaffolds. We will also discuss the current dilemma and possible development direction from a biomedical perspective.

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“…With the wide application of percutaneous coronary intervention (PCI) technology, the quality of life of patients with coronary heart disease has been signifcantly improved [4]. SYNTAX score can refect the complexity of coronary artery, but with the increase of its value, the incidence of adverse cardiovascular and cerebrovascular events after PCI increases signifcantly, such as death, stroke, and myocardial infarction [5][6][7]. Analyzing the infuencing factors of SYNTAX score has guiding signifcance for clinical treatment of coronary heart disease.…”

Section: Introductionmentioning

confidence: 99%

Functional Evaluation of Percutaneous Coronary Intervention Based on CT Images of Three-Dimensional Reconstructed Coronary Artery Model

Liu

Shao

et al. 2023

Contrast Media & Molecular Imaging

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In order to explore the computerized tomography (CT) based on three-dimensional reconstruction of coronary artery model, the functional evaluation was made after percutaneous coronary intervention (PCI). In this study, 90 patients with coronary heart disease who received elective PCI were selected. The blood flow reserve fraction (FFR) and SYNTAX score were calculated by three-dimensional reconstruction of CT images, followed up for 2–4 years. According to the SYNTAX score, 0–22 points were defined as the low group (28 cases), 23–32 points as the medium group (33 cases), and 33 points as the high group (29 cases). In this paper, the accuracy, sensitivity, and specificity of CT images of three-dimensional reconstructed coronary artery model are 91%, 73%, and 62%, respectively. The follow-up results showed that the incidence of major adverse cerebrovascular events in the high group was significantly higher than that in the low group and the middle group, and the difference was statistically significant ( P < 0.05 ). Pearson correlation analysis showed that SYNTAX score was related to serum total cholesterol (r = 0.234, P = 0.003 ), triglyceride (r = 0.237, P = 0.014 ), low-density lipoprotein cholesterol (r = 0.285, P = 0.004 ), and ApoB/ApoA1 (R = 0.004). In this study, FFR is calculated by CT images based on three-dimensional reconstruction of coronary artery model, which can provide support for the diagnosis and treatment of coronary heart disease. SYNTAX score can be used as a risk predictor for PCI patients with coronary heart disease.

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Predictive value of LncRNA on coronary restenosis after percutaneous coronary intervention in patients with coronary heart disease

Cited by 6 publications

References 16 publications

Is elevated triglyceride/high-density lipoprotein cholesterol ratio associated with poor prognosis of coronary heart disease? A meta-analysis of prospective studies

Is elevated triglyceride/high-density lipoprotein cholesterol ratio associated with poor prognosis of coronary heart disease? A meta-analysis of prospective studies

Emerging technologies for cardiac tissue engineering and artificial hearts

Functional Evaluation of Percutaneous Coronary Intervention Based on CT Images of Three-Dimensional Reconstructed Coronary Artery Model

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