Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Carslake, David; Tynelius, Per; Berg, Gerard van den; Smith, George Davey; Rasmussen, Finn

doi:10.1038/srep45278

Cited by 32 publications

(33 citation statements)

References 61 publications

(83 reference statements)

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“…In daughters with low or normal childhood relative weight, birth to a teenage mother was associated with a higher risk of adult overweight and with slightly shorter stature, which may have partially mediated the association between mother's age at delivery and daughter's risk of preeclampsia. While the association with height is in agreement with previous reports, 19…”

Section: Principal Findingssupporting

confidence: 93%

“…effect of advanced maternal age on offspring body weight, glucose metabolism, and blood pressure comes from a mouse study in which pups conceived by young and old dams were transferred into young surrogate mothers at the blastocyst stage. 18 In humans, it is reasonably well established that offspring of older mothers tend to be taller [19][20][21] and have a slightly higher risk of childhood type 1 diabetes (5% per 5-year increase in mother's age, according to a meta-analysis of 30 studies). 22 However, the evidence linking mother's age at delivery with offspring blood pressure, 19,[23][24][25][26] glucose metabolism, 20,27,28 and, especially, body mass index (BMI) [19][20][21][29][30][31][32][33][34] is mixed.…”

mentioning

confidence: 99%

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Mother’s age at delivery and daughters’ risk of preeclampsia

Basso

Weinberg

D’Aloisio

et al. 2019

Paediatric Perinatal Epid

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Background Some cardiovascular disease risk factors are associated with both risk of preeclampsia and having been born to a younger or older mother. We examined whether mother's age at delivery predicts a primiparous daughter's risk of preeclampsia. Methods The analysis included 39 803 Sister Study participants (designated as “daughters”) born between 1930 and 1974. Using log‐binomial regression, we estimated relative risks (RR) of preeclampsia in the first pregnancy ending in birth (“primiparous preeclampsia”) associated with mother's age at the daughter’s birth. Models included: number of older full and maternal half‐siblings, income level growing up, daughter's age at delivery, race/ethnicity, and 5‐year birth cohort. We examined self‐reported relative weight at age 10 (heavier than peers versus not) as a potential effect measure modifier. Results Overall, 6.2% of daughters reported preeclampsia. Compared with those who had been born to 20‐24‐year old mothers, daughters of teenage mothers had a relative risk of 1.20 (95% confidence interval (CI) 1.01, 1.43) and daughters of mothers ≥25 had a ~10% lower risk. Relative weight at age 10 modified the association, with an inverse association between mother's age at delivery and preeclampsia seen only among daughters with low/normal childhood relative weight. In this subset, results were consistent across strata of daughter's age at menarche and age at first birth. Conclusions These findings, based on self‐reported data, require replication. Nevertheless, as women increasingly delay childbearing, they provide some reassurance that having been born to an older mother is not, per se, a risk factor for primiparous preeclampsia.

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Section: Principal Findingssupporting

confidence: 93%

mentioning

confidence: 99%

Mother’s age at delivery and daughters’ risk of preeclampsia

Basso

Weinberg

D’Aloisio

et al. 2019

Paediatric Perinatal Epid

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“…Epidemiological and demographic studies in humans have shown a negative correlation between maternal age and children’s lifespan and health 25,27,30,45,46 . However, maternal age effects in humans can be difficult to separate from confounding environmental factors including paternal age effects, parental health, parental socio-economic status, and parental care 47-49 . Additionally, in human studies, both genotype and environment are usually uncharacterized, and it is impossible to systematically and simultaneously vary maternal age and offspring environment for a given genotype.…”

Section: Introductionmentioning

confidence: 99%

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Bock

Jarvis

Corey³

et al. 2019

Preprint

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18Maternal age has a negative effect on offspring lifespan in a range of taxa and is hypothesized 19 to influence the evolution of aging. However, the mechanisms of maternal age effects are 20 unknown, and it remains unclear if maternal age alters offspring response to therapeutic 21 interventions to aging. Here, we evaluate maternal age effects on offspring lifespan, 22 reproduction, and the response to caloric restriction, and investigate maternal investment as a 23 source of maternal age effects using the rotifer, Brachionus manjavacas, an aquatic invertebrate. 24 We found that offspring lifespan and fecundity decline with increasing maternal age. Caloric 25 restriction increases lifespan in all offspring, but the magnitude of lifespan extension is greater in 26 the offspring from older mothers. The trade-off between reproduction and lifespan extension 27 under low food conditions expected by life history theory is observed in young-mother offspring, 28 but not in old-mother offspring. Age-related changes in maternal resource allocation to 29 reproduction do not drive changes in offspring fitness or plasticity under caloric restriction in B. 30 manjavacas. Our results suggest that the declines in reproduction in old-mother offspring negate 31 the evolutionary fitness benefits of lifespan extension under caloric restriction. 32 33 KEYWORDS 34 Maternal effects; aging; caloric restriction; evolutionary fitness; maternal investment 35 36 37 38Maternal effects occur when the environment or physiological state of a mother changes the 39 phenotype of her offspring without a corresponding change in genotype. Offspring phenotype 40 may be modified in response to maternal environmental factors including diet, temperature, or 41 exposure to stressors [1][2][3][4][5][6][7][8][9][10][11] . Such maternal effects may be adaptive as in Daphnia and rotifers, in 42 which offspring hatch with protective spines upon maternal exposure to predators [2][3][4][5][6]12 , or as in 43 plants, in which offspring have higher rates of germination and survival when planted in the 44 same high-light or low-light environment as their parent 7,8 . Alternatively, maternal effects may 45 be detrimental as is the case in the negative health outcomes for children due to excessive 46 maternal smoking or alcohol consumption during pregnancy [13][14][15] . We are beginning to 47 understand that maternal effects may be mediated by a variety of epigenetic mechanisms, 48 including direct transmission of maternal proteins, mRNA, lncRNA, miRNA, and modifications to 49 DNA and histones [16][17][18][19][20] . While maternal effects have long been studied and are well known in 50 the ecological literature, there has been a recent rise in interest in maternal effects in the context 51 of human health and aging 21 . 53Maternal age, or the age of a mother at the time her offspring are born, has been shown to have 54 a negative effect on offspring health in a range of taxa [22][23][24][25][26][27][28][29][30][31][32] . A decrea...

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“…There was no association between a woman's mother's age at her birth and healthy survival to age 90, and parental ages were not associated with death before age 90 in this cohort of older women. Associations of parental ages with childhood and adulthood health outcomes among offspring have been mixed, and few studies have examined aging outcomes, such as exceptional longevity or healthy aging [4][5][6][7][8][9][10][11][12][13][14][15][16]. A prospective study among > 5000 adults ages 65 years and older observed no associations of parental ages with mortality or frailty in old age among sons or daughters [7].…”

Section: Discussionmentioning

confidence: 99%

“…Studies examining associations of parental ages at childbirth with offspring health outcomes have yielded inconsistent findings, and few studies have examined aging outcomes [4][5][6][7][8][9][10][11][12][13][14][15][16]. Some studies have linked older parental age at childbirth to outcomes including neurodevelopmental disorders, obesity, mortality, and morbidities including cancer among offspring in childhood and adulthood [4,[9][10][11][12]14].…”

Section: Introductionmentioning

confidence: 99%

Associations of parental ages at childbirth with healthy aging among women

Shadyab

Manson

et al. 2019

Maturitas

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Objective: To examine associations of parental ages at childbirth with healthy survival to age 90 years among older women. Study Design: This study included a racially and ethnically diverse sub-cohort of 8,983 postmenopausal women from the larger Women's Health Initiative population, recruited during 1993-1998 and followed for up to 25 years through 2018. Main Outcome Measures: The outcome was categorized as: 1) healthy survival, defined as survival to age 90 without major morbidities (coronary heart disease, stroke, diabetes, cancer, or hip fracture) or mobility disability; 2) usual survival, defined as survival to age 90 without healthy aging (reference category); or 3) death before age 90. Women reported their own and their parents' birth years, and parental ages at childbirth were calculated and categorized as < 25, 25-29, 30-34, or ≥35 years. Results: Women were aged on average 71.3 (standard deviation 2.7; range 65-79) years at baseline. There was no significant association of maternal age at childbirth with healthy survival to age 90 or death before age 90. Women born to fathers aged ≥35 compared with 30-34 years at their births were more likely to achieve healthy than usual survival (OR, 1.15; 95% CI, 1.00-1.32). There was no association of paternal age at childbirth with death before age 90. Conclusions: Findings suggest that being born to older fathers was associated with healthy survival to age 90 among women who had survived to ages 65-79 years at study baseline. There was no association of maternal age at childbirth with healthy survival to age 90 among these older women.

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Associations of parental age with health and social factors in adult offspring. Methodological pitfalls and possibilities

Cited by 32 publications

References 61 publications

Mother’s age at delivery and daughters’ risk of preeclampsia

Mother’s age at delivery and daughters’ risk of preeclampsia

Maternal age alters offspring lifespan, fitness, and lifespan extension under caloric restriction

Associations of parental ages at childbirth with healthy aging among women

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