Associations of PFAS-related plasma metabolites with cholesterol and triglyceride concentrations

Schillemans, Tessa; Bergdahl, Ingvar A.; Hanhineva, Kati; Shi, Lin; Donat‐Vargas, Carolina; Koponen, Jani; Kiviranta, Hannu; Landberg, Rikard; Åkesson, Agneta; Brunius, Carl

doi:10.1016/j.envres.2022.114570

Cited by 10 publications

(5 citation statements)

References 54 publications

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“…In fact, the current data demonstrate that exposomic and metabolomic approaches (as represented by our control method) are highly complementary, and thousands of additional molecular features can be followed if both approaches are applied together for wide coverage of environmental and endogenous substances. Indeed, specific plasma phospholipids have been associated with environmental chemical exposures, 77 , 78 but it is evident here that removal of phospholipids brings advantages to exploration of the exposome, consistent with previous conclusions for exploration of the metabolome. 20 Application of both methods to the same samples may be limited by sample volumes, as well as cost and analysis time considerations.…”

Section: Resultssupporting

confidence: 89%

Phospholipid Removal for Enhanced Chemical Exposomics in Human Plasma

Sdougkou

Xie

Papazian

et al. 2023

Environ. Sci. Technol.

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The challenge of chemical exposomics in human plasma is the 1000-fold concentration gap between endogenous substances and environmental pollutants. Phospholipids are the major endogenous small molecules in plasma, thus we validated a chemical exposomics protocol with an optimized phospholipid-removal step prior to targeted and non-targeted liquid chromatography high-resolution mass spectrometry. Increased injection volume with negligible matrix effect permitted sensitive multiclass targeted analysis of 77 priority analytes; median MLOQ = 0.05 ng/mL for 200 μL plasma. In non-targeted acquisition, mean total signal intensities of non-phospholipids were enhanced 6-fold in positive (max 28-fold) and 4-fold in negative mode (max 58-fold) compared to a control method without phospholipid removal. Moreover, 109 and 28% more non-phospholipid molecular features were detected by exposomics in positive and negative mode, respectively, allowing new substances to be annotated that were non-detectable without phospholipid removal. In individual adult plasma (100 μL, n = 34), 28 analytes were detected and quantified among 10 chemical classes, and quantitation of per- and polyfluoroalkyl substances (PFAS) was externally validated by independent targeted analysis. Retrospective discovery and semi-quantification of PFAS-precursors was demonstrated, and widespread fenuron exposure is reported in plasma for the first time. The new exposomics method is complementary to metabolomics protocols, relies on open science resources, and can be scaled to support large studies of the exposome.

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Section: Resultssupporting

confidence: 89%

Phospholipid Removal for Enhanced Chemical Exposomics in Human Plasma

Sdougkou

Xie

Papazian

et al. 2023

Environ. Sci. Technol.

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“…Meanwhile, the negative relationships between PFAS concentration and the triglyceride and LDL levels (Figure S5) observed in this study were consistent with previous research. 19,70,71 The PFAS-induced activation of the nuclear receptor PPARα may be the mechanism of these inverse relationships. 72 Furthermore, PFAS concentrations in the third trimester were significantly related to two blood proteins: albumin and hemoglobin.…”

Section: Discussionmentioning

confidence: 99%

Prenatal Exposure of PFAS in Cohorts of Pregnant Women: Identifying the Critical Windows of Vulnerability and Health Implications

Luo,

Li,

et al. 2024

Environ. Sci. Technol.

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Cohorts of pregnant women in 2018 and 2020 were selected to explore prenatal exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS). Maternal serum during the whole pregnancy (first to third trimesters) and matched cord serum were collected for the analysis of 50 PFAS. Perfluorooctanoic acid (PFOA), perfluorooctanesulfonic acid (PFOS), and 6:2 fluorotelomer sulfonic acid (6:2 FTS) were the dominant PFAS in both the maternal and cord serum. The median ∑PFAS concentration was 14.18 ng/mL, and the ∑PFAS concentration was observed to decline from the first trimester to the third trimester. The transplacental transfer efficiencies (TTE) of 29 PFAS were comprehensively assessed, and a "U"-shaped trend in TTE values with increasing molecular chain length of perfluoroalkyl carboxylic acid (PFCA) was observed in this study. Moreover, the maternal concentrations of 9-chlorohexadecafluoro-3-oxanonane-1-sulfonic acid (6:2 Cl-PFESA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), perfluoroundecanoic acid (PFUdA), perfluorododecanoic acid (PFDoA), PFOS, and hexafluoropropylene oxide dimer acid (HFPO−DA) in the 2020 cohort were significantly lower than those in the 2018 cohort, declining by about 23.85−43.2% from 2018 to 2020 (p < 0.05). Higher proportions of emerging PFAS were observed in fetuses born in 2020. This birth cohort was collected during the COVID-19 epidemic period. The change in the PFAS exposure scene might be in response to the different exposure profiles of the 2018 and 2020 cohorts, which are attributed to the impact of COVID-19 on the social activities and environment of pregnant women. Finally, by application of a multiple informant model, the third trimester was identified as the critical window of vulnerability to PFAS exposure that affects birth weight and birth length.

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“…To our knowledge, no reports on associations between PFASs and diglycerides have been made; however, there are several examples of how PFAS exposures alter the concentrations of other blood lipids. 70–73 Based on this, the interaction between the lipidome and PFASs is important to investigate in human health.…”

Section: Discussionmentioning

confidence: 99%