Associations of Self-Reported Sleep Quality with Circulating Interferon Gamma-Inducible Protein 10, Interleukin 6, and High-Sensitivity C-Reactive Protein in Healthy Menopausal Women

Abstract

IntroductionSleep disturbance is very common in menopausal women and poor sleep quality has been linked to systemic inflammation. However, the impact of poor sleep quality on health outcomes of menopausal women remains unclear. This study evaluated the relationships between sleep quality and inflammation in menopausal women.Participants and designThis cross-sectional study enrolled 281 healthy women aged 45 to 60 years. The Pittsburgh Sleep Quality Index (PSQI) was used to measure quality of sleep. Multiplex assays were used to measure the levels of 9 cytokines in morning fasting plasma samples. Other variables measured in this study included clinical characteristics and high-sensitivity C-reactive protein (hs-CRP).SettingThe study was performed at a medical center.ResultsThe 281 participants comprised 79 (28%) perimenopausal women and 202 (72%) postmenopausal women. Global PSQI scores were positively correlated with plasma hs-CRP levels (P = 0.012) and were marginally associated with interferon gamma-inducible protein-10 (IP10), interleukin 6 (IL6), and macrophage inflammatory protein-1beta (MIP-1β) levels. After adjusting for age, body mass index, menopause duration, and follicle stimulating hormone, multiple linear regression analysis revealed that high PSQI scores and sleep efficiency < 65% were associated with elevated plasma levels of hs-CRP, IP10, and IL6. In addition, sleep duration < 5 hours was associated with high hs-CRP levels.ConclusionOur data show that poor sleep quality and low sleep efficiency are associated with elevated levels of circulating inflammatory factors IP10, IL6 and hs-CRP and that short sleep duration is associated with high levels of hs-CRP in menopausal women. These findings provide novel evidence that poor sleep quality is linked to low-grade systemic inflammation in menopausal women.

Replication and reproducibility issues in the relationship between C-reactive protein and depression: A systematic review and focused meta-analysis

“…Physical activity is also a protective factor against the development of depressive disorders (Strawbridge et al, 2002). Sleep deprivation has been increasingly linked to elevated CRP levels (Meier-Ewert et al, 2004) as has poor quality of sleep (Huang et al, 2017). Moreover, disruptions in sleep have also been linked to more severe presentations of depression (Tsuno et al, 2005).…”

Sleep in Women Across the Life Span

“…81 In summary, primary sleep disorders become more prevalent in older age, affecting > 53% of postmenopausal women. [103][104][105] Moreover, poor sleep in perimenopausal/postmenopausal women is associated with inflammation, 106 cardiovascular and metabolic disease, [107][108][109] and mood disorders. Understanding the evolution of sleep across a woman's life span may lead to effective therapies that affect women's health and quality of life.…”

Association of sleep duration and quality with elevated hs-CRP among healthy Korean adults

“…Previous studies investigated the effects of sleep disorders such as obstructive sleep apnea [20,21] and insomnia [22] on hs-CRP levels. Several studies have evaluated the association between sleep characteristics and hs-CRP level among the general population [6,9,13,23]; the results, however, derive from mainly western population or are conservative in sample size [24][25][26][27][28]. A 2009 study carried out by the Organization for Economic Cooperation and Development reported that Koreans ranked at the bottom of 18 countries for sleep time; a nationwide study found that nearly 20% of Korean adults were affected by insomnia, reflecting an increase from 2002 survey [29,30].…”