Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Sak, Sibel; Uyanıkoğlu, Hacer; Incebiyik, Adnan; İncebıyık, Hatice; Hilali, Neşe Gül; Sabuncu, Tevfik; Sak, Erdal

doi:10.5653/cerm.2018.45.3.116

Cited by 27 publications

(26 citation statements)

References 26 publications

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“…In the current investigate, we found that circulating Fetuin-A concentrations were markedly elevated in PCOS women compared with healthy women. Our results are consistent with those of Enli et al [28,[30][31], but contrary to those of Díaz et al [20]. The cross-sectional nature of studies and population heterogeneity in women with PCOS may be related to differences in outcomes.…”

Section: Discussionsupporting

confidence: 88%

“…However, the conclusions of these studies are contradictory. In previous studies, circulating Fetuin-A levels were increased, decreased or unchanged in PCOS patients compared with normal women [20,[27][28][29][30][31]. In the current investigate, we found that circulating Fetuin-A concentrations were markedly elevated in PCOS women compared with healthy women.…”

Section: Discussionsupporting

confidence: 60%

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Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

et al. 2019

Preprint

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Background: Insulin resistance (IR) is a common characteristic in women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, in PCOS women, previous reports on changes in circulating Fetuin-A concentrations were inconsistent. Methods: A cross-sectional study was conducted, including 122 PCOS women and 85 healthy women. Circulating Fetuin-A levels were determined using an ELISA kit. Results: We found that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most normal women (95 %). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.2 vs. 313.8 ± 60.4 μg/L; p <0.01). Serum Fetuin-A concentrations correlated positively with WHR, LDL-C, FIns, HOMA-IR, TEST and DHEA-S. Multivariate regression analysis showed that WHR, HOMA-IR and TEST were independent influencing factors of serum Fetuin-A. Binary logistic regression reaveled that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. Conclusion: Blood Fetuin-A may be a useful biomarker for screening women with PCOS and IR.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionsupporting

confidence: 60%

Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

et al. 2019

Preprint

View full text Add to dashboard Cite

show abstract

“…In the current investigation, we found that circulating Fetuin-A concentrations were markedly elevated in women with PCOS compared to healthy women. Our results are consistent with those of Enli et al [33][34][35], but contrary to those of Díaz et al [22]. The cross-sectional nature of the study and population heterogeneity may be related to differences in outcomes.…”

Section: Discussionsupporting

confidence: 86%

“…However, the conclusions of these studies are contradictory. In previous studies, circulating Fetuin-A levels were increased, decreased or unchanged in PCOS patients compared with normal women [22,[31][32][33][34][35]. In the current investigation, we found that circulating Fetuin-A concentrations were markedly elevated in women with PCOS compared to healthy women.…”

Section: Discussionsupporting

confidence: 59%

Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

et al. 2020

Preprint

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Background Insulin resistance (IR) is a common characteristic in women with polycystic ovary syndrome (PCOS). It has been reported that circulating Fetuin-A levels were associated with IR and type 2 diabetes mellitus (T2DM). However, previous reports on changes in circulating Fetuin-A concentrations in women with PCOS have been inconsistent. Methods 207 subjects were screened for PCOS according to the diagnostic guideline of the Rotterdam consensus criterion. Serum Fetuin-A levels were measured using an ELISA kit. An independent t- test or Nonparametric tests was used to detect differences between PCOS and control groups. The association of the serum Fetuin-A with other parameters was examined by spearman’s correlation analysis. Results Our findings show that circulating Fetuin-A concentration ranged from 196.6 to 418.2 µg/L for most women without PCOS (95%). Women with PCOS have higher circulating Fetuin-A levels than healthy women (437.9 ± 119.3 vs. 313.8 ± 60.5 μg/L; p < 0.01). Serum Fetuin-A was positively correlated with BMI, WHR, TG, TC, LDL-C, HOMA-IR, LH, T and DHEA-S. Multivariate regression analysis showed that WHR, TG, HOMA-IR and DHEA-S were independent predictors of the levels of circulating Fetuin-A. Binary logistic regression revealed that serum Fetuin-A was associated with the .occurrence of PCOS. In addition, our ROC curve analysis found that the cutoff values for Fetuin-A to predict PCOS and IR were 366.3 and 412.6 µg/L. ConclusionBlood Fetuin-A may be a useful biomarker for screening women for PCOS and IR.

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“…Kidney and liver tissues were washed with saline at +4 °C, dried on blotting paper and stored in 1 ml storage vials and stored in deep freezer (-80 °C) until analyses were performed. Before the analyses, renal and liver tissues were homogenized using a homogenizer (Stuart, SHM1/ EURO, UK) by adding (10 %, w/v) 140 mM KCl solution at +4 °C (10). The obtained homogenates were centrifuged at 3000 rpm for 5 minutes at +4 °C.…”

Section: Biochemical Analysismentioning

confidence: 99%

Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice

Devrim¹,

Ekici²,

Devrim³

et al. 2020

BLL

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BACKGROUND: Skin is the body's fi rst defence against direct exposure to variety of chemicals. Polycyclic aromatic hydrocarbons such as 3-methylcholanthrene (3-MC) are common in polluted urban air and have a potential of producing harmful effects. Moreover, their late effects can occur months or years after exposure. OBJECTIVES: We aimed to investigate the long-term effects of 3-MC induced dermal toxicity on the expression of markers of apoptosis, pleiotropic cytokines, and oxidative stress and to determine the protective effect of cisplatin. METHODS: Groups were designed as control (group 1), 3-MC applied (group 2) and 3-MC+cisplatin applied mice (group 3). Cutaneous expressions of TGFβ, PDGFA, PDGFC, bFGF, PDGFRα, USP28, and Ki67 were evaluated with qPCR. Total oxidant (TOS), total antioxidant (TAS) and oxidative stress index (OSI) values were determined in liver and kidney tissues. RESULTS: The expression levels of TGFβ, PDGFRα, USP-28, Ki67, and PDGFA were decreased signifi cantly in MC applied groups. Renal TAS levels were signifi cantly lower in group-3. Liver and kidney OSI values were increased in both groups 2 and 3. CONCLUSION: The results indicated that low dose 3-MC caused oxidative stress and downregulated apoptotic and cytokine markers in the long term and cisplatin had no ameliorative effects on this degeneration processes (Tab.

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Associations of serum fetuin-A and oxidative stress parameters with polycystic ovary syndrome

Cited by 27 publications

References 26 publications

Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

Serum Fetuin-A levels were increased and associated with insulin resistance in women with polycystic ovary syndrome

Late effects of cutaneous 3-methylcholanthrene exposure on DNA damage-related pleiotropic growth factors and oxidative stress markers in mice

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