Associations of SMAD4 rs10502913 and NLRP3 rs1539019 Polymorphisms with Risk of Coal Workers’ Pneumoconiosis Susceptibility in Chinese Han Population

Zhang, Hai; Huang, Yongye; Wang, Hao; Zhao, Jianmin; Tian, Senlin; Bai, Haixia; Guo, Mufang; Dong, Caiping; Shi, Yongliang; Li, Xia; Zhu, Chengjun; Feng, Tao; Ma, Xuchu; Hou, Zhifei

doi:10.2147/pgpm.s351658

Cited by 2 publications

(2 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A case-control study indicated that the G allele of SMAD4 rs10502913 did not alter the risk of CWP compared with the A allele, and the GG genotypes did not increase the CWP risk compared with the AA genotype. 13 Another study based on the Health Professionals Follow-up and Nurses’ Health Study in the United States showed there is no association between SMAD4 rs10502913 polymorphism and type 2 diabetes risk. 35 However, it is still unclear which signaling pathways or target genes SMAD4 rs10502913 acts through, and further studies are needed to clarify its molecular mechanism.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

Hou¹,

Yuan²,

Wang³

et al. 2022

COPD

Self Cite

View full text Add to dashboard Cite

Background COPD is a respiratory disease caused by a combination of genetic and environmental factors. Polymorphism, as a genetic factor, can affect the susceptibility of the disease of COPD. In this study, we assessed the relationship between the polymorphisms of three genes and COPD risk in a Chinese Han population. Patients and Methods A total of 376 patients diagnosed with COPD and 284 control subjects were enrolled in this study. Multivariate logistic regression analysis was used to analyze the association between three polymorphisms (SMAD4 rs10502913, IL-4 rs2070874, HSPA1L rs2227956) and COPD susceptibility. Results The SMAD4 rs10502913 GG and AG genotype significantly increased COPD risk (adjusted OR = 2.235, 95% CI 1.198–4.104; adjusted OR = 2.218, 95% CI 1.204–4.151, respectively) compared with the AA genotype. In the stratification analyses, the GG genotype significantly increased the risk of COPD in subjects aged 60 and over (adjusted OR = 2.519, 95% CI 1.266–5.015) and with a smoking history of less than 30 years ( p =0.009; adjusted OR = 3.751; 95% CI 1.398–10.062). This increased risk was more pronounced in the group of GOLD I and GOLD II (adjusted OR = 3.628, 95% CI 1.022–12.885; adjusted OR = 2.394, 95% CI 1.004–5.710, respectively). In addition, AG genotype was associated with an increased COPD risk in subjects aged 60 and over (adjusted OR = 2.599, 95% CI 1.304–5.176) and in smokers ( p =0.021; adjusted OR = 2.269; 95% CI 1.132–4.548). This increased risk was more obvious in the group of GOLD III COPD ( p =0.047; adjusted OR = 2.532; 95% CI 1.012–6.336). Conclusion Our present study indicated that the genotype GG and AG of SMAD4 rs10502913 are associated with an increased risk of COPD in a Chinese Han population. Further validation studies with large-scale populations are needed to confirm our findings.

show abstract

Section: Discussionmentioning

confidence: 99%

“…Furthermore, SMAD4 rs10502913 genotypes had no interaction with CWP risk in a stratified analysis of smokers and never-smokers. 13 However, the functionality of SMAD4 rs10502913 SNP in COPD has not yet been reported.…”

Section: Introductionmentioning

confidence: 99%

SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

Hou¹,

Yuan²,

Wang³

et al. 2022

COPD

Self Cite

View full text Add to dashboard Cite

show abstract

Polymorphism of antioxidant defense enzyme genes as the risk for formation of chronic dust bronchitis in long-term labour experience coal mine workers

Kazitskaya

Yadykina²,

Gulyaeva³

et al. 2023

Hygiene and Sanitation

View full text Add to dashboard Cite

Introduction. The antioxidant defense system is involved in protecting the body from long-term exposure to harmful damaging factors. Polymorphisms in the genes of antioxidant defense enzymes change the response to oxidative stress in occupational respiratory diseases such as asbestosis, silicosis, occupational asthma, and others. The aim was to study the polymorphism of the MnSOD (rs4880) and GPX1 (rs1050450) genes to predict the risk of developing chronic dust bronchitis in miners of the main occupations of coal enterprises in the South of Kuzbass. Materials and methods. One hundred eighty two coal mine workers with long-term exposure to high concentrations of coal-rock dust (exceeding the maximum permissible concentrations by up to 35 times), including 116 people with a previously proven diagnosis of chronic dust bronchitis, were examined. The comparison group (66 workers) consisted of the persons without a proven diagnosis, working in the same sanitary and hygienic conditions. Genomic DNA was isolated from peripheral blood leukocytes using phenol-chloroform extraction method. Typing of the MnSOD (rs4880) and GPX1 (rs1050450) genes was performed using the Real-Time method. Results. The chance of detecting the AA genotype of the MnSOD gene and the GG genotype of the GPX1 gene in long-term labour experience miners with chronic dust bronchitis was found to be 2 times and 6 times higher than in the comparison group, respectively. The AA GPX1 genotype had been shown to be a factor in resistance to the development of this disease. The combination of AA/GG genotypes of the MnSOD/GPX1 genes was statistically significantly associated with a 1.5-fold risk of developing chronic dust bronchitis. Combinations of genotypes of the MnSOD/GPX1 GG/AA, AA/AA, and AG/AA genes were associated with the resistance to the development of chronic dust bronchitis. The data obtained can be used for personalized prediction of the risk of developing chronic dust bronchitis in long-term labour experience miners of the main occupations. Limitations. The study was limited to the number of miners who underwent periodic medical examinations and were hospitalized at the Research Institute for Complex Problems of Hygiene and Occupational Diseases. Conclusion. The results obtained indicate to the contribution of the polymorphism of the MnSOD (rs4880) and GPX1 (rs1050450) genes to the development of chronic dust bronchitis.

show abstract

Associations of SMAD4 rs10502913 and NLRP3 rs1539019 Polymorphisms with Risk of Coal Workers’ Pneumoconiosis Susceptibility in Chinese Han Population

Cited by 2 publications

References 34 publications

SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

SMAD4 rs10502913 is Significantly Associated with Chronic Obstructive Pulmonary Disease in a Chinese Han Population: A Case-Control Study

Polymorphism of antioxidant defense enzyme genes as the risk for formation of chronic dust bronchitis in long-term labour experience coal mine workers

Contact Info

Product

Resources

About