Associations of the ANKK1 and DRD2 gene polymorphisms with overweight, obesity and hedonic hunger among women from the Northwest of Iran

Aliasghari, Fereshteh; Nazm, Saba A.; Yasari, Sepideh; Mahdavi, Reza; Bonyadi, Morteza

doi:10.1007/s40519-020-00851-5

Cited by 32 publications

(18 citation statements)

References 54 publications

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“…In addition, this polymorphism was linked to increased BMI and eating disorders in women with bulimia spectrum disorder [26-27], which is considered a possible marker for the high risk of developing pathological eating behavior [28]. Other studies showed that the presence of the T allele for the DRD2 gene is associated with unhealthy eating, abnormal levels of glucose and triglycerides [29], other addictive behaviors combined with overweight [30], obesity [31], hedonic diet [32], and high sensitivity to reward [33].…”

Section: Discussionmentioning

confidence: 99%

DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery

et al. 2021

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Aim: To analyze the association and susceptibility of Single Nucleotide Polymorphisms (SNPs) in the DRD2 and BDNF genes with BED in patients with weight regain in the postoperative period of bariatric surgery. Methods: 177 individuals who underwent bariatric surgery with weight regain were evaluated and divided into two groups according to the BED diagnostic. The individuals were submitted to an anthropometric evaluation, analysis of the presence of BED using a validated questionnaire, and blood collection for genotyping of the polymorphisms rs6265 (BDNF) and rs1800497 (DRD2) by Real-Time Polymerase Chain Reaction (RT-PCR). Results: the presence of wild-type alleles for rs1800497 (CC) and rs6265 (GG) were more frequent in patients without BED. Nevertheless, the presence of one or two variant alleles for rs1800497 (CT+TT) and rs6265 (GA+AA) was more frequent in patients with BED. The combination of the two studied SNPs prevailed in patients with BED.Conclusions: In the presence of polymorphisms rs1800497 in the DRD2 gene and rs6265 in the BDNF gene, isolated and/or combined could occur an additional risk for the development of BED in patients with obesity, especially in the context of weight regain.

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Section: Discussionmentioning

confidence: 99%

DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery

et al. 2021

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“…In a study of patients with the first episode of schizophrenia [ 60 ], it was found that carriers of the Del allele of the functional polymorphism −141C Ins/Del (rs1799732) had significantly greater weight gain after six weeks of treatment, regardless of the prescribed medication [ 60 ]. In a sample of women from Northwest Iran, the association of allele rs1799732*Del with overweight/obesity cases was shown [ 61 ]. In addition, the DRD2 gene polymorphism (rs1799732) showed a significant association with BMI and hedonic hunger [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia

Paderina

Boiko

Pozhidaev

et al. 2022

Genes

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Background: Metabolic syndrome is widespread in patients with schizophrenia receiving long-term antipsychotic therapy. Dopamine D2 receptors play an important role in mediating both the therapeutic actions of antipsychotics and their side effects. The present study examined the association of two polymorphisms of the DRD2 gene with metabolic syndrome in patients with schizophrenia. Methods: We examined 517 patients from several regions of Siberia (Russia) with a clinical diagnosis of schizophrenia. Genotyping of two single nucleotide polymorphisms rs1799732 and rs4436578 of the dopamine D2 receptor gene (DRD2) was performed in a population of 471 patients. The results were analyzed using chi-square tests. Results: Functional polymorphism rs1799732 of the DRD2 gene is associated with drug-induced metabolic syndrome in women with schizophrenia. Conclusions: Our results show that the DRD2 gene may be involved in the pathogenesis of metabolic disorders in patients with schizophrenia. Further analysis of possible genetic markers will allow for personalized treatment with minimal side effects and optimal efficacy. This which seems relevant in light of the recent focus on improving the quality of life and ensuring a high level of social adaptation of patients with schizophrenia.

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“…In addition, they seem to be related to increased BMI and eating disorders in women with bulimia spectrum disorder [34][35], being considered a possible marker for high risk of developing pathological eating behavior [36]. In addition, other studies show that the presence of the T allele for the DRD2 gene is associated with unhealthy eating, abnormal levels of glucose and triglycerides [37], other addictive behaviors combined with overweight [38], obesity [39], hedonic diet [40], and high sensitivity to reward [41], which directly in uences the increase in caloric intake [42]. However, it is important to note that these variables were not evaluated in this study.…”

Section: Discussionmentioning

confidence: 99%

DRD2 and BDNF Polymorphisms Are Associated With Binge Eating Disorder (BED) in Patients With Weight Regain After Bariatric Surgery

Nonino

Barato

Ferreira

et al. 2021

Preprint

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Objectives: Verify the frequency of polymorphisms related to obesity and Binge Eating Disorder (BED) in DRD2 and BDNF genes in patients undergoing bariatric surgery with weight regain above 10% of the weight lost. Methods: Evaluation of 177 individuals undergoing bariatric surgery with weight regain, divided into two groups: Group 1: individuals with BED; Group 2: individuals without BED. The individuals were submitted to anthropometric evaluation, analysis of the presence of BED using a validated questionnaire, and blood collection for genotyping of the polymorphisms, rs6265 (BDNF) and rs1800497 (DRD2). The Kolmogorovi-Smirnov, t-test, chi-square, Mann Whitney, Pearson correlation were used for statistical analysis. Results: CC genotypes for rs1800497 polymorphism, and GG for rs6265 polymorphism were more frequent in patients without the disorder. The presence of at least one T allele (DRD2) and at least one A allele (BDNF) was more frequent in patients with BED. The combination of AA + GA + TT + TC genotypes prevailed in patients with the disorder. Conclusions: The CC (DRD2) and GG (BDNF) genotypes suggest protection for patients against BED, while genotypes that have at least one T allele (DRD2) and one A allele (BDNF) suggest greater risk and appear to act in synergism.Level of evidence: III (evidence obtained from case-control analytic study).

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Associations of the ANKK1 and DRD2 gene polymorphisms with overweight, obesity and hedonic hunger among women from the Northwest of Iran

Cited by 32 publications

References 54 publications

DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery

DRD2 and BDNF polymorphisms are associated with binge eating disorder in patients with weight regain after bariatric surgery

The Gender-Specific Association of DRD2 Polymorphism with Metabolic Syndrome in Patients with Schizophrenia

DRD2 and BDNF Polymorphisms Are Associated With Binge Eating Disorder (BED) in Patients With Weight Regain After Bariatric Surgery

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