Associations of urinary and dietary cadmium with urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and blood biochemical parameters

Urbano, T. Guerrero; Filippini, Tommaso; Wise, Lauren A.; Lasagni, Donatella; Luca, Tiziana De; Sucato, Sabrina; Polledri, Elisa; Malavolti, Marcella; Rigon, Chiara; Santachiara, Annalisa; Pertinhez, Thelma A.; Baricchi, Roberto; Fustinoni, Silvia

doi:10.1016/j.envres.2022.112912

Cited by 17 publications

(6 citation statements)

References 71 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although the dietary characteristics could be generally similar to those of other Italian populations, some distinctive characteristics may be present due to the regional differences that have been taken into account in the final version of the FFQ [77,78]. Another strength is that it was possible to perform stratified analyses to highlight possible sex-specific effects, as well as the minimal invasiveness of our study due to blood sampling that is already part of a programmed annual pathway, where the participants are donors of blood and derivatives [44]. In addition, recruitment was conducted over approximately two calendar years (March 2017 to April 2019), so distortionary effects due to the season in which the questionnaire was completed by participants could be partially ruled out, also because the EPIC questionnaire contains specific questions that focus on the seasonality of foods consumed, especially fruits and vegetables [79][80][81].…”

Section: Discussionmentioning

confidence: 81%

“…We recruited healthy blood donors aged between 30 and 60 years without a history of chronic disease or cancer from the Reggio Emilia AUSL-IRCCS Transfusion Medicine Unit. Each participant was asked to complete a questionnaire concerning medical history and personal information [44]. We measured their height and weight to calculate body mass index (BMI) and systolic and diastolic blood pressure levels with a manual sphygmomanometer during the medical examination prior to blood donation.…”

Section: Study Population and Proceduresmentioning

confidence: 99%

“…We analyzed them on collection day at the central AUSL-IRCCS laboratory. We assessed the following metabolic parameters using automated laboratory procedures as previously described [44]: complete blood count, including mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), red blood cell distribution width (RDW), reticulocyte count, platelet count (PLT), white blood cell or leukocyte count, hemoglobin (Hb), ferritin, blood glucose, alanine aminotransferase (ALT) and lipid profile (total cholesterol, HDLcholesterol, triglycerides); creatinine; and total protein. In particular, we quantified the total cholesterol, HDL cholesterol, triglyceride and glucose levels using an AEROSET c8000 system (Abbott Diagnostic, IL, USA) [53].…”

Section: Blood Biochemical and Metabolic Parameter Measurementsmentioning

confidence: 99%

“…We used an Atellica ® analyzer (Siemens Healthcare Diagnostic, NY, USA) to quantify TSH levels [54]. To determine ALT concentration, we used an automated enzymatic colorimetric assay [44]. Laboratory reference values for biochemical parameters are shown in Table S1.…”

Section: Blood Biochemical and Metabolic Parameter Measurementsmentioning

confidence: 99%

See 3 more Smart Citations

Dietary Patterns and Blood Biochemical and Metabolic Parameters in an Italian Population: A Cross-Sectional Study

et al. 2022

View full text Add to dashboard Cite

Diet has long been identified as a major determinant of cardiovascular and other chronic diseases. In this study, we assess the relation between adherence to different dietary patterns and biochemical and metabolic parameters as well as the 10-year risk of major cardiovascular diseases (CVDs) in a community of blood donors in Northern Italy. We assess their adherence to four dietary patterns, namely, the Dietary Approach to Stop Hypertension (DASH) diet, the Mediterranean diet through the Greek and Italian Mediterranean Indices (GMI and IMI) and the Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) diet, using a validated semi-quantitative food frequency questionnaire (FFQ). We then assess their association with blood parameters and the 10-year risk of major CVD using a spline regression model. We found an inverse association between the DASH and MIND diets and total and LDL cholesterol, and triglyceride and HDL cholesterol values for the Mediterranean diets (IMI and GMI). Additionally, according to our sex-stratified analyses, men who have greater adherence to dietary patterns have a decreased risk of major CVD for all patterns. The results suggest that greater adherence to dietary patterns positively influences blood biochemical and metabolic parameters, thus reducing the risk of developing cardiovascular disease and delaying the use of drug treatments.

show abstract

Section: Discussionmentioning

confidence: 81%

Section: Study Population and Proceduresmentioning

confidence: 99%

Section: Blood Biochemical and Metabolic Parameter Measurementsmentioning

confidence: 99%

Section: Blood Biochemical and Metabolic Parameter Measurementsmentioning

confidence: 99%

See 2 more Smart Citations

Dietary Patterns and Blood Biochemical and Metabolic Parameters in an Italian Population: A Cross-Sectional Study

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Essential metals (e.g., copper (Cu), selenium (Se)) are important for good health if consumed within tolerable limits, but non-essential metals (e.g., As, cadmium (Cd)) may be toxic and may have a negative impact on health if consumed in quantities that exceed safety thresholds (e.g., neurotoxicity, cognitive impairment, carcinogenicity) (Tchounwou et al 2012 ). Additionally, recent research further indicates that metal exposure not exceeding national or international guidelines may also illicit negative affect health effects (e.g., hepatic, vascular) (Urbano et al 2022 ; Urbano et al 2021 ). Likewise, organohalogens (e.g., PCBs) and pesticides (e.g., dichlorodiphenyltrichloroethane (DDT)) are of concern because they persist in the environment.…”

Section: Introductionmentioning

confidence: 99%

A probabilistic hazard and risk assessment of exposure to metals and organohalogens associated with a traditional diet in the Indigenous communities of Eeyou Istchee (northern Quebec, Canada)

Moriarity

Tsuji

2022

Environ Sci Pollut Res

View full text Add to dashboard Cite

Hunting, trapping, and fishing are part of an Indigenous lifestyle in subarctic Canada. However, this lifestyle may be a route of exposure to contaminants and may pose a risk for the people who rely on a subsistence diet. Monte Carlo simulations for the chemical concentration of eight game species and one fish species were carried out by randomly sampling 10,000 samples from the contaminant measures for each species. We then calculated a probabilistic non-carcinogenic hazard quotient or carcinogenic risk values to estimate the human health risk of exposure to contaminants. Of the species examined, ducks were of concern for potential carcinogenic risk. There was a modeled probabilistic 95th-percentile risk associated with the consumption of ducks and polybrominated biphenyl (PBB) congener 153 in boys, women, and men (1.09 × 10−6, 1.57 × 10−6, and 2.17 × 10−6, respectively) and, to a lesser extent, with geese and polychlorinated biphenyl (PCB) congener 153 in men (1.19 × 10−6). Contaminant concentration in the intake rate (food consumption) for PBB congener 153 exposure risk was more important than that for PCB congener 153, where intake rate had greater relevance. The consumption of waterfowl may increase the exposure to organohalogens; however, there are health and wellness benefits associated with the harvesting and consumption of subsistence foods that must also be considered. We recommend follow-up species-specific studies focused on ducks to clarify and elucidate the results in the present study.

show abstract

Sex-Specific Associations of Urinary Metals with Renal Function: a Cross-sectional Study in China

Lin

Cai

Liu

et al. 2022

Biol Trace Elem Res

View full text Add to dashboard Cite

Background: Extensive studies revealed the association between heavy metals and CKD. Compared with single meta, the mixtures metals re ect metals exposure scenarios in real life and deserves attention.While the mechanism of action of the metal mixture on renal function is still unde ned. Methods: A cross-sectional study involving 2775 participants was conducted. Urinary concentrations of heavy metals were measured by inductively coupled plasma mass spectrometry, and the estimated glomerular ltration rate (eGFR) for renal function was calculated. The association of metals with eGFR was estimated by linear regression. Interaction of the metal mixture was used to evaluate by using a Bayesian nuclear machine regression model (BKMR).Results: In linear regression, urinary As (β = 2.723, P<0.05) and Pb (β = 3.081, P<0.05) were positively correlated with eGFR in total population. In BKMR model, the mixture of ve metals had a positive joint effect on eGFR levels, and Pb (PIP = 0.996) contributed the most to the eGFR levels. Pb was signi cantly and positively associated with eGFR levels in total participants and women. As was signi cantly and positively associated with eGFR levels in women. Pb displayed a signi cant and positive effect when all the other metals were xed at 25th, 50th, and 75th percentiles.Conclusions: To the best of our knowledge All ve metals mixed exposure was positively associated with eGFR, while Pb was demonstrated more important effects than the other four metals in the mixture, especially in women.

show abstract

Associations of urinary and dietary cadmium with urinary 8-oxo-7,8-dihydro-2′-deoxyguanosine and blood biochemical parameters

Cited by 17 publications

References 71 publications

Dietary Patterns and Blood Biochemical and Metabolic Parameters in an Italian Population: A Cross-Sectional Study

Dietary Patterns and Blood Biochemical and Metabolic Parameters in an Italian Population: A Cross-Sectional Study

A probabilistic hazard and risk assessment of exposure to metals and organohalogens associated with a traditional diet in the Indigenous communities of Eeyou Istchee (northern Quebec, Canada)

Sex-Specific Associations of Urinary Metals with Renal Function: a Cross-sectional Study in China

Contact Info

Product

Resources

About