Associations of Variations in Alcohol Dehydrogenase Genes With the Level of Response to Alcohol in Non‐Asians

Duranceaux, Nicole C.E.; Schuckit, Marc A.; Eng, Mimy Y.; Robinson, Shannon K.; Carr, Lucinda G.; Wall, Tamara L.

doi:10.1111/j.1530-0277.2006.00178.x

Cited by 49 publications

(45 citation statements)

References 72 publications

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“…Although some studies have found that the ADH1B*2 allele is associated with a lower rate of alcohol dependence (Tanaka et al, 1996;Wall et al, 2005b;Whitfield, 1997), others have not (Luczak et al, 2004;Takeshita et al, 1994). Furthermore, some alcohol challenge studies have found significant associations between ADH1B and level of response to alcohol Duranceaux et al, 2006), but others have not (Heath et al, 1999;Peng et al, 2002). Thus, prior data do not consistently support the hypothesis that ADH1B*2 leads to decreased rates of alcohol dependence via a more intense response to alcohol, and any such relationship may be further obscured when level of response to alcohol is assessed using self-report.…”

Section: Discussionmentioning

confidence: 99%

Ethnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans

Duranceaux

Schuckit

Luczak

et al. 2008

J. Stud. Alcohol Drugs

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Objective-Koreans have higher rates of alcohol-use disorders and family history of alcoholism, compared with Chinese. These differences likely reflect both environmental and genetic influences. One genetically influenced characteristic that may contribute to these ethnic differences is level of response to alcohol. Variant alleles of aldehyde dehydrogenase (ALDH2) and alcohol dehydrogenase (ADH1B) genes are prevalent in individuals of Asian heritage and have been associated with an increased level of response to alcohol and a decreased risk for alcohol dependence. Additionally, a low level of response to alcohol is more common in individuals with a first-degree family history of alcoholism and is predictive of increased risk for this disorder. It also is possible that sociocultural factors have an impact on an individual's response to alcohol. The current study examined self-report level of response to alcohol, ALDH2 and ADH1B, country of origin, and family history of alcoholism in 154 Chinese-and 181 Korean-American college students.Method-Participants were evaluated via in-person interviews and genotyped at the ALDH2 and ADH1B loci.Results-Ethnicity was significantly related to level of response to alcohol, with Koreans having a lower self-reported level of response than Chinese. This relationship remained significant after considering the effects of gender, height, weight, quantity and frequency of alcohol consumption (over the previous 90 days), ALDH2 genotype, ADH1B genotype, country of origin, and first-degree family history of alcohol dependence.

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Section: Discussionmentioning

confidence: 99%

Ethnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans

Duranceaux

Schuckit

Luczak

et al. 2008

J. Stud. Alcohol Drugs

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“…With that, foetuses of mothers who carry the rare variant have a reduced exposure to alcohol compared to foetuses of mothers who carry the common variant. This negative association is very robust and has been replicated in numerous independent genetic studies (Reich et al, 1998;Whitfield et al, 1998;Saccone et al, 2000Saccone et al, , 2005Loew et al, 2003;Wall et al, 2005;Duranceaux et al, 2006;Luo et al, 2006;Zintzaras et al, 2006;Zhang et al, 2007;Ghosh et al, 2008;Tolstrup et al, 2008;Macgregor et al, 2009;Sherva et al, 2009;Zuccolo et al, 2009), confirming Assumption 3; we show the standard statistical tests below. This means that the potential exposure or treatment for child i whose mother does not carry the rare variant is at least as high as the potential treatment for the same child whose mother does carry the rare variant, for all i.…”

Section: Potential Outcomes Frameworkmentioning

confidence: 96%

Alcohol Exposure In Utero and Child Academic Achievement

Hinke¹,

Wehby²,

Lewis³

et al. 2014

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We examine the effect of prenatal alcohol exposure on child academic achievement. We use a genetic variant in the maternal alcohol-metabolism gene ADH1B to instrument for alcohol exposure, whilst controlling for the child's genotype on the same variant. We show that the instrument is unrelated to an extensive range of parental characteristics and behaviour. OLS regressions suggest an ambiguous association between alcohol exposure and attainment but there is a strong social gradient in drinking, with mothers in higher socio-economic groups more likely to drink. In contrast to the OLS, the IV estimates show clear negative effects of prenatal alcohol exposure.

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“…Los efectos aversivos del etanol incluyen alteraciones fisiológicas periféricas como, molestias gastrointestinales (Adinoff, Iranmanesh, Veldhius y Fisher, 1998) y reacciones autonómicas (Duranceaux et al, 2006), así como efectos sobre el sistema nervioso central (SNC) (revisado en Pautassi et al, 2009).…”

Section: Propiedades Aversivas Del Etanolunclassified

“…Por último, cabe mencionar la existencia de diferencias, determinadas genética y/o ambientalmente, en la sensibi-lidad a los efectos aversivos del etanol, y éstas podrían, por tanto, influir sobre la probabilidad de búsqueda y consumo de etanol, como se extrae de diversas investigaciones realizadas con roedores (revisado en Broadbent et al, 2002;Escarabajal, 2003;y, Green y Grahame, 2008) y también con humanos (véase Duranceaux et al, 2006). En general, se ha observado que aquellos individuos que muestran mayores índices de CAG tienen una menor preferencia por el alcohol.…”

Section: Propiedades Aversivas Del Etanolunclassified

“…Tradicionalmente se ha considerado a los factores genéticos como los principales determinantes del alcoholismo. La existencia de variaciones genéticas en la sensibilidad a los efectos del etanol es un hecho bien contrastado en roedores (Broadbent, Muccino y Cunningham, 2002, y Pautassi, Camarini, Quadros, Miczek, e Israel, 2010 y en humanos (Duranceaux et al, 2006; ver Escarabajal, 2003 para revisión). Pero en las últimas dos décadas dicha primacía ha sido de alguna manera moderada por la investigación epidemiológica y preclínica, que pone de manifiesto la importancia de factores relacionados con la experiencia.…”

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Una revisión de la literatura experimental sobre los efectos motivacionales del alcohol y su modulación por factores biológicos y ambientales.

2013

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Resumen: El alcohol es posiblemente la droga psicoactiva más consumida en el mundo. La ingesta moderada es común, pero para algunos individuos el consumo de alcohol se convierte en un trastorno adictivo. La progresión desde un consumo moderado de alcohol hasta el abuso podría deberse a la existencia de una sensibilidad diferencial, genéticamente determinada, a los efectos reforzantes y aversivos del alcohol. Así mismo, se sugiere que factores ambientales, como el estrés, podrían intervenir en el inicio del alcoholismo, influyendo sobre dicha sensibilidad diferencial y, en última instancia, sobre el consumo de alcohol. En el presente trabajo se revisa la literatura experimental existente acerca de los elementos protagonistas en la relación entre estrés y etanol. Por una parte se revisan los principales modelos de estrés existentes y, por otra, se aborda el estudio de las propiedades reforzantes y aversivas de esta droga, incluyendo datos sobre la influencia de variables como la edad, el sexo, y la experiencia previa con la droga. Finalmente, se expone un resumen de los datos existentes sobre la investigación con animales sobre la influencia del estrés en la percepción de las propiedades motivacionales opuestas del etanol. Nuestro objetivo es contribuir a clarificar el conocimiento existente acerca de las relaciones entre determinados factores biológicos (como el sexo o la edad) y ambientales (experiencia previa y estrés), y la conducta de ingesta de alcohol, poniendo de manifiesto la importancia de algunos factores de riesgo para el desarrollo del alcoholismo. Palabras clave: Alcohol; estrés; refuerzo; aversión; adicción.Title: A review of experimental literature on alcohol´s motivational effects and its modulation by biological and environmental factors. Abstract: Alcohol is probably the most consumed psychoactive drug in the world. Controlled consumption of alcohol is common, but for many individuals this consumption becomes an addiction. The progression from an habitual consumption of alcohol to abuse of the substance could be due to the existence of a differential sensitivity, which would be genetically determined, to the reinforcing and aversive effects of alcohol. Likewise, it has been suggested that environmental factors such as stress might be involved in the onset of alcoholism, influencing on such a differential sensitivity and, ultimately, on the consumption of alcohol. In this paper it is reviewed the experimental published data on each of the elements of the relationship between stress and ethanol. Thus, on the one hand they are reviewed the main animals models of stress and, on the other hand, we approached the study of the reinforcing and aversive properties of ethanol, including data on the influence of variables such as age, sex, and previous experience with the drug. And, finally, we present a resume of data collected from animal research on the influence of stress on the perception of the motivational opposing properties of ethanol. Our purpose is help to clarify the existing knowledge about th...

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Associations of Variations in Alcohol Dehydrogenase Genes With the Level of Response to Alcohol in Non‐Asians

Abstract: These findings suggest that studies searching for genes relating to the LR to alcohol as a vulnerability factor for AUDs should consider controlling for ADH1B genotype, as the ADH1B*2 allele could obscure the impact of other genetic polymorphisms.

Cited by 49 publications

References 72 publications

Ethnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans

Ethnic Differences in Level of Response to Alcohol Between Chinese Americans and Korean Americans

Alcohol Exposure In Utero and Child Academic Achievement

Una revisión de la literatura experimental sobre los efectos motivacionales del alcohol y su modulación por factores biológicos y ambientales.

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