Associative reinstatement memory measures hippocampal function in Parkinson's Disease

Cohn, Mélanie; Giannoylis, Irene; Belder, Maya De; Saint‐Cyr, Jean A.; McAndrews, Mary Pat

doi:10.1016/j.neuropsychologia.2016.04.026

Cited by 21 publications

(27 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although this could be an impaired recollection in PD as they could not recollect the pairs in same order, it could very well be due to executive deficit in remembering order of the face-scene picture pair. This aspect of remembering order of items has been shown to be dependent on dorsolateral prefrontal cortex (Ragland et al 2012), and was bypassed by Cohn and his colleagues (Cohn et al 2016) in this study by using the reinstatement task, which in turn minimized the involvement of executive function (that are deficient in PD) and thus helped in studying recollection-specific performance. It is crucial to control for executive function because recollection is not only dependent upon memoryrelated aspects like encoding and storage, but also upon executive functioning (Rubin et al 2017).…”

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

“…With regard to recollection and familiarity, most studies suggest a disrupted recollection as the critical episodic memory deficit in PD, while familiarity is normal with respect to healthy controls (Algarabel et al 2010, Cohn et al 2016, Cohn et al 2010, Edelstyn et al 2007, Rodriguez et al 2014. However, a few studies have showed the opposite effect, i.e., disruption of familiarity but normal recollection in PD as compared to heathy controls (Davidson et al 2006, Weiermann et al 2010.…”

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

“…Cohn and colleagues (Cohn et al 2016) further used an associative reinstatement memory (ARM) task to study whether deficient recollection in PD was associated with lower hippocampal activation. Associative memory, like recognition memory, is a subcomponent of episodic memory and is the ability to remember relationships between unrelated items and eventually forming a relation between them, hence is also called relational memory.…”

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

“…Hippocampus is known to be involved in reinstatement, triggering the process of recollection replete with rich contextual details (Cohn et al 2009). Cohn and colleagues (Cohn et al 2016) demonstrated that patients with PD had lower ARM scores compared to the healthy controls with simultaneous lower hippocampus activation for the ARM condition. This study clearly showed a lower recollection in PD and concomitant lower associative memory.…”

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

See 3 more Smart Citations

Episodic recognition memory and the hippocampus in Parkinson's disease: A review

Das

Hwang

Poston

2019

Cortex

View full text Add to dashboard Cite

Parkinson's disease is a progressive neurodegenerative disorder of aging. The hallmark pathophysiology includes the development of neuronal Lewy bodies in the substantia nigra of the midbrain with subsequent loss of dopaminergic neurons. These neuronal losses lead to the characteristic motor symptoms of bradykinesia, rigidity, and rest tremor. In addition to these cardinal motor symptoms patients with PD experience a wide range of non-motor symptoms, the most important being cognitive impairments that in many circumstances lead to dementia. People with PD experience a wide range of cognitive impairments; in this review we will focus on memory impairment in PD and specifically episodic memory, which are memories of day-today events of life. Importantly, these memory impairments severely impact the lives of patients and caregivers alike. Traditionally episodic memory is considered to be markedly dependent on the hippocampus; therefore, it is important to understand the exact nature of PD episodic memory deficits in relation to hippocampal function and dysfunction. In this review, we discuss an aspect of episodic memory called recognition memory and its subcomponents called recollection and familiarity. Recognition memory is believed to be impaired in PD; thus, we discuss what aspects of the hippocampus are expected to be deficient in function as they relate to these recognition memory impairments. In addition to the hippocampus as a whole, we will discuss the role of hippocampal subfields in recognition memory impairments.

show abstract

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

Section: Episodic Recognition Memory In Pdmentioning

confidence: 99%

See 2 more Smart Citations

Episodic recognition memory and the hippocampus in Parkinson's disease: A review

Das

Hwang

Poston

2019

Cortex

View full text Add to dashboard Cite

show abstract

“…Table 1 summarizes all fMRI studies retrieved from the literature search. Three task‐based fMRI studies were reviewed (Cohn et al., 2016; Ibarretxe‐Bilbao et al., 2011; Nagano‐Saito et al., 2014). Nagano‐Saito et al.…”

Section: Discussionmentioning

confidence: 99%

Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies

Pourzinal,

Yang,

Bakker

et al. 2021

J of Neuroscience Research

View full text Add to dashboard Cite

The present review asks whether magnetic resonance imaging (MRI) studies are able to define neural correlates of episodic memory within the hippocampus in Parkinson's disease (PD). Systematic searches were performed in PubMed, Web of Science, Medline, CINAHL, and EMBASE using search terms related to structural and functional MRI (fMRI), the hippocampus, episodic memory, and PD. Risk of bias was assessed for each study using the Newtown–Ottawa Scale. Thirty‐nine studies met inclusion criteria; eight fMRI, seven diffusion MRI (dMRI), and 24 structural MRI (14 exploring whole hippocampus and 10 exploring hippocampal subfields). Critical analysis of the literature revealed mixed evidence from functional and dMRI, but stronger evidence from sMRI of the hippocampus as a biomarker for episodic memory impairment in PD. Hippocampal subfield studies most often implicated CA1, CA3/4, and subiculum volume in episodic memory and cognitive decline in PD. Despite differences in imaging methodology, study design, and sample characteristics, MRI studies have helped elucidate an important neural correlate of episodic memory impairment in PD with both clinical and theoretical implications. Natural progression of this work encourages future research on hippocampal subfield function as a potential biomarker of, or therapeutic target for, episodic memory dysfunction in PD.

show abstract

Cognitive and behavioral disorders in Parkinson’s disease: an update. I: cognitive impairments

Papagno

Trojano

2017

Neurol Sci

View full text Add to dashboard Cite

Parkinson's disease (PD) is a progressive neurodegenerative disease characterized by motor symptoms such as rigidity, rest tremor, and bradykinesia. However, a growing body of evidence demonstrated that PD encompasses several non-motor disturbances as well, such as cognitive impairment. Cognitive defects can be present since early stages of the disease but tend to dominate the clinical picture as the disease progresses. Around 40% of patients with PD present with cognitive impairments in several cognitive domains including attention, working memory and executive functions, language, visuospatial skills, and episodic memory; in later stages of the disease, cognitive defects and associated behavioral disorders concur to determine clinically relevant PD-associated dementia. Part of these defects is ascribed to a dopamine-dependent dysfunction of fronto-striatal pathways, but there is a considerable heterogeneity in the cognitive impairments as well as a suggestion of the role of other neurotransmitter systems, such as the cholinergic one, mainly responsible for Parkinson-dementia syndrome. In this paper, we review recent literature with particular attention to the last 5 years on the main cognitive deficits described in PD patients as well as on the hypothesized neuro-functional substrate of such impairments. Finally, we provide some suggestions on how to test cognitive functions in PD appropriately.

show abstract

Associative reinstatement memory measures hippocampal function in Parkinson's Disease

Cited by 21 publications

References 58 publications

Episodic recognition memory and the hippocampus in Parkinson's disease: A review

Episodic recognition memory and the hippocampus in Parkinson's disease: A review

Hippocampal correlates of episodic memory in Parkinson’s disease: A systematic review of magnetic resonance imaging studies

Cognitive and behavioral disorders in Parkinson’s disease: an update. I: cognitive impairments

Contact Info

Product

Resources

About