Assortative mating and affective disorders

Negri, F.; Melica, A. M.; Zuliani, Rizki; Smeraldi, Enrico

doi:10.1016/0165-0327(79)90011-9

Cited by 28 publications

(18 citation statements)

References 11 publications

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“…According to the assortative mating hypothesis, people with similar characteristics, for example, depressive tendencies, (Merikangas, Bromet, & Spiker, 1983;Negri, Melicia, Zuliani, & Smeraldi, 1979) tend to choose each other as mates. According to the assortative mating hypothesis, people with similar characteristics, for example, depressive tendencies, (Merikangas, Bromet, & Spiker, 1983;Negri, Melicia, Zuliani, & Smeraldi, 1979) tend to choose each other as mates.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, an explanation that we cannot fully negate is that the problems reported by these wives were not caused by their husbands' disorder. According to the assortative mating hypothesis, people with similar characteristics, for example, depressive tendencies, (Merikangas, Bromet, & Spiker, 1983;Negri, Melicia, Zuliani, & Smeraldi, 1979) tend to choose each other as mates. The subjects in the current study were, however, all married prior to their husbands' traumatic experiences, and they did not, therefore, chose to marry a CSR or PTSD veteran.…”

Section: Discussionmentioning

confidence: 99%

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From Front Line to Home Front: A Study of Secondary Traumatization

et al. 1992

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While the long-term effects of combat trauma on veterans have been studied extensively, its impact on veterans' wives has yet to be investigated. This study examined the implications of combat-induced psychopathology--wartime combat stress reaction (CSR) and current posttraumatic stress disorder (PTSD)--in a sample of 205 wives of Israeli combat veterans of the 1982 Lebanon war. Results show that both CSR and PTSD were associated with increased psychiatric symptoms in the wives. In addition, current PTSD was particularly found to contribute to impaired social relations among veterans' wives in a broad range of contexts, from inner feelings of loneliness, through impaired marital and family relations, and extending to the wider social network. Implications of these findings for treatment and further research are discussed.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

From Front Line to Home Front: A Study of Secondary Traumatization

et al. 1992

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“…Such common alleles could create a pseudo-dominant transmission pattern, 48 especially in conjunction with the assortative mating that is common among people with mood disorders. 49 The replication design we employed made it possible to separate out some robust association signals from among the large set of statistically significant results in this genome-wide study. However, some of the most significant results in the NIMH sample did not replicate in the German sample, and by design, we did not pursue association signals present only in the German sample.…”

Section: Ae Baum Et Almentioning

confidence: 99%

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

et al. 2007

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The genetic basis of bipolar disorder has long been thought to be complex, with the potential involvement of multiple genes, but methods to analyze populations with respect to this complexity have only recently become available. We have carried out a genome-wide association study of bipolar disorder by genotyping over 550 000 single-nucleotide polymorphisms (SNPs) in two independent case-control samples of European origin. The initial association screen was performed using pooled DNA, and selected SNPs were confirmed by individual genotyping. While DNA pooling reduces power to detect genetic associations, there is a substantial cost saving and gain in efficiency. A total of 88 SNPs, representing 80 different genes, met the prior criteria for replication in both samples. Effect sizes were modest: no single SNP of large effect was detected. Of 37 SNPs selected for individual genotyping, the strongest association signal was detected at a marker within the first intron of diacylglycerol kinase eta (DGKH; P = 1.5 Â 10 À8 , experiment-wide P < 0.01, OR = 1.59). This gene encodes DGKH, a key protein in the lithium-sensitive phosphatidyl inositol pathway. This first genome-wide association study of bipolar disorder shows that several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease.

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“…The spouses of depressed persons appear to have difficulties of their own which often predate the marriage (Merikangas, 1984). Depressed women from clinical and community samples are more likely than other women to be married to men with personal and family histories of depression, substance abuse and personality disorders (Merikangas & Spiker, 1982;Negri et al, 1979;Peterson, Coyne & Kessler, 1990). Evidence suggests that this is due to assortative mating: the diagnosable problems of both depressed persons and their spouses tend to have emerged before they were married (Peterson et al, 1990).There are also similarities between depressed persons and their spouses in terms of adverse childhood experiences and deviance as adolescents, and these shared background characteristics may be a key predictor of how destructive a depressed person and their spouse become when dealing with conflict , and, in turn, of the risk for a disturbed family climate and subsequent relapse.…”

Section: Marital Functioningmentioning

confidence: 99%

Depression, the Family, and Family Therapy

Coyne

Fechner-Bates

1992

ANZ J of Family Therapy

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The potential contribution of family therapists to the treatment of depression remains underdeveloped. Family therapists need to articulate how changes in family functioning might benefit depressed persons, as well as how other problems in the families of depressed persons tend to go unrecognised. Furthermore, family therapists need to be alert to how undetected depression in adults and children may interfere with their ability to meet their goals with families who seek therapy for other persons. This article provides family therapists with (1) an overview of the nature and experience of depression; (2) an introduction to antidepressant medication; (3) a summary of research findings relating depression to its family context and (4) a brief overview of developments in the marital and family treatment of depression.

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Assortative mating and affective disorders

Cited by 28 publications

References 11 publications

From Front Line to Home Front: A Study of Secondary Traumatization

From Front Line to Home Front: A Study of Secondary Traumatization

A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder

Depression, the Family, and Family Therapy

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