Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

Rodriguez-Ruiz, Violeta; Salatti-Dorado, José Ángel; Barzegari, Abolfazl; Nicolas‐Boluda, Alba; Houaoui, Amel; Caballo, Carmen; Caballero-Casero, Noelia; Sicilia, María Dolores; Venegas, Jorge Bastias; Pauthe, Emmanuel; Omidi, Yadollah; Letourneur, Didier; Rubio, Soledad; Gueguen, Virginie; Pavon‐Djavid, Graciela

doi:10.3390/molecules23102601

Cited by 52 publications

(52 citation statements)

References 36 publications

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“…These findings point out the crucial role of drug incorporation, which was able to protect the drug and preserve the antioxidant activity. These results are corroborated by previous findings, which reported the improvement of the antioxidant activity of drug molecules when incorporated into lipid drug delivery systems [48][49][50].…”

Section: Samplesupporting

confidence: 91%

Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?

et al. 2020

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Nowadays, an increasing interest in combinatorial drug delivery systems is emerging, highlighting the possibility of exploiting essential oils (EO) for topical applications. This work aimed at developing nanostructured lipid carriers (NLC) for the combined delivery of ferulic acid and Lavandula EO, whose beneficial effects in wound-healing processes have been widely reported. Homogeneous (polydispersity index, PDI < 0.2) nanoparticles with a small size (<150 nm) and a high encapsulation efficiency (>85%) were obtained. The co-presence of ferulic acid and Lavandula EO, as compared to synthetic isopropyl myristate-based NLC, increased nanoparticles’ stability, due to higher ordering chains, as confirmed by morphological and physicochemical studies. An enhanced cytocompatibility was observed when combining ferulic acid and Lavandula EO, as confirmed by in vitro studies on fibroblasts. Furthermore, the combined delivery of ferulic acid and Lavandula EO significantly promoted cell migration with higher effectiveness in respect to the free drug solution and the carrier without the EO. Taken all together, our results suggest a potential combined effect of the antioxidant ferulic acid and Lavandula EO co-delivered in lipid nanoparticles in promoting cell proliferation and migration, representing a promising strategy in the treatment of wounds.

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Section: Samplesupporting

confidence: 91%

Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?

et al. 2020

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“…A polymeric matrix or a coating layer around a particular compound provides a physical barrier, preserves its biological activity, and enhances its physicochemical stability [23,35,36]. Lipid-based carriers based on microemulsion, nanoemulsion, or an association of both referred as solid lipid nanoparticles or nanostructured lipid carriers were shown to stabilize ASX [33,37,38]. A clinical trial revealed the improvement of ASX bioavailability when incorporated into a lipid-based carrier [39].…”

Section: Administration Doses and Toxicity Studiesmentioning

confidence: 99%

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

et al. 2020

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Oxidative stress (OS) plays a pivotal role in diabetes mellitus (DM) onset, progression, and chronic complications. Hyperglycemia-induced reactive oxygen species (ROS) have been shown to reduce insulin secretion from pancreatic β-cells, to impair insulin sensitivity and signaling in insulin-responsive tissues, and to alter endothelial cells function in both type 1 and type 2 DM. As a powerful antioxidant without side effects, astaxanthin (ASX), a xanthophyll carotenoid, has been suggested to contribute to the prevention and treatment of DM-associated pathologies. ASX reduces inflammation, OS, and apoptosis by regulating different OS pathways though the exact mechanism remains elusive. Based on several studies conducted on type 1 and type 2 DM animal models, orally or parenterally administrated ASX improves insulin resistance and insulin secretion; reduces hyperglycemia; and exerts protective effects against retinopathy, nephropathy, and neuropathy. However, more experimental support is needed to define conditions for its use. Moreover, its efficacy in diabetic patients is poorly explored. In the present review, we aimed to identify the up-to-date biological effects and underlying mechanisms of ASX on the ROS-induced DM-associated metabolic disorders and subsequent complications. The development of an in-depth research to better understand the biological mechanisms involved and to identify the most effective ASX dosage and route of administration is deemed necessary.

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“…Astaxanthin, a naturally occurring keto-carotenoid, exhibits strong antioxidant and antidiabetic effects [318]. Astaxanthin-assembled nanostructured lipid carriers demonstrated the capability of improving the stability and enhancing the antioxidant activity of astaxanthin [168]. Astaxanthin-loaded chitosan oligosaccharides-PLGA core-shell nanoparticles have been found to improve the water solubility, stability, bioavailability, cytocompatibility, and sustained release profile of astaxanthin as compared to native astaxanthin [319].…”

Section: Other Plant-derived Antidiabetic Nanoformulationsmentioning

confidence: 99%

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

Dewanjee

Chakraborty

Mukherjee

et al. 2020

IJMS

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Diabetes mellitus is a life-threatening metabolic syndrome. Over the past few decades, the incidence of diabetes has climbed exponentially. Several therapeutic approaches have been undertaken, but the occurrence and risk still remain unabated. Several plant-derived small molecules have been proposed to be effective against diabetes and associated vascular complications via acting on several therapeutic targets. In addition, the biocompatibility of these phytochemicals increasingly enhances the interest of exploiting them as therapeutic negotiators. However, poor pharmacokinetic and biopharmaceutical attributes of these phytochemicals largely restrict their clinical usefulness as therapeutic agents. Several pharmaceutical attempts have been undertaken to enhance their compliance and therapeutic efficacy. In this regard, the application of nanotechnology has been proven to be the best approach to improve the compliance and clinical efficacy by overturning the pharmacokinetic and biopharmaceutical obstacles associated with the plant-derived antidiabetic agents. This review gives a comprehensive and up-to-date overview of the nanoformulations of phytochemicals in the management of diabetes and associated complications. The effects of nanosizing on pharmacokinetic, biopharmaceutical and therapeutic profiles of plant-derived small molecules, such as curcumin, resveratrol, naringenin, quercetin, apigenin, baicalin, luteolin, rosmarinic acid, berberine, gymnemic acid, emodin, scutellarin, catechins, thymoquinone, ferulic acid, stevioside, and others have been discussed comprehensively in this review.

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Astaxanthin-Loaded Nanostructured Lipid Carriers for Preservation of Antioxidant Activity

Cited by 52 publications

References 36 publications

Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?

Ferulic Acid-NLC with Lavandula Essential Oil: A Possible Strategy for Wound-Healing?

Impact of Astaxanthin on Diabetes Pathogenesis and Chronic Complications

Plant-Based Antidiabetic Nanoformulations: The Emerging Paradigm for Effective Therapy

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