Asthma and depression: the Cooper Center Longitudinal Study

Trojan, Timothy; Khan, David A.; DeFina, Laura F.; Akpotaire, Oviea; Goodwin, Renée D.; Brown, E. Sherwood

doi:10.1016/j.anai.2014.02.015

Cited by 36 publications

(19 citation statements)

References 46 publications

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“…Recently, numerous studies have demonstrated that anxiety and depression are common and relevant comorbidities in asthmatic patients [ 15 – 17 ]. In this study, to investigate the correlation among different presentations of asthma and psychiatric disorders, all patients were evaluated with SAS and SDS questionnaires.…”

Section: Resultsmentioning

confidence: 99%

Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

Cao

Huang

et al. 2017

J Transl Med

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BackgroundIt is now recognized that asthma can present in different forms. Typically, asthma present with symptoms of wheeze, breathlessness and cough. Atypical forms of asthma such as cough variant asthma (CVA) or chest tightness variant asthma (CTVA) do not wheeze. We hypothesize that these different forms of asthma may have distinctive cellular and molecular features.Methods30 patients with typical or classical asthma (CA), 27 patients with CVA, 30 patients with CTVA, and 30 healthy control adults were enrolled in this prospective study. We measured serum IgE, lung function, sputum eosinophils, nitric oxide in exhaled breath (FeNO). We performed proteomic analysis of induced-sputum supernatants by mass spectrometry.ResultsThere were no significant differences in atopy and FEV1 among patients with CA, CVA, and CTVA. Serum IgE, sputum eosinophil percentages, FeNO, anxiety and depression scores were significantly increased in the three presentations of asthmatic patients as compared with healthy controls but there was no difference between the asthmatic groups. Comprehensive mass spectrometric analysis revealed more than a thousand proteins in the sputum from patients with CA, CVA, and CTVA, among which 23 secreted proteins were higher in patients than that in controls.ConclusionsPatients with CA, CVA, or CTVA share common clinical characteristics of eosinophilic airway inflammation. And more importantly, their sputum samples were composed with common factors with minor distinctions. These findings support the concept that these three different presentations of asthma have similar pathogenetic mechanism in terms of an enhanced Th2 associated with eosinophilia. In addition, this study identified a pool of novel biomarkers for diagnosis of asthma and to label its subtypes. Trial registration http://www.chictr.org.cn (ChiCTR-OOC-15006221)Electronic supplementary materialThe online version of this article (doi:10.1186/s12967-017-1264-y) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

Cao

Huang

et al. 2017

J Transl Med

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“…Trojan et al reported that asthma was associated with current depressive symptoms and lifetime history of depression, but neither lung function nor asthma controller medications were associated with depression, and depression with asthma does not appear to be exclusively related to severe or poorly controlled asthma [53].…”

Section: Depression and Anxiety Levels In Cva And Classic Asthma Patimentioning

confidence: 96%

Cough variant asthma patients are more depressed and anxious than classic asthma patients

Saito

Itoga

Tamaki

et al. 2015

Journal of Psychosomatic Research

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“…Two emotional responses that have been repeatedly linked to medical conditions such as asthma are depressive and anxious symptoms (American Psychiatric Association, [APA], 2013; McLeish, Luberto, & O’Bryan, 2016; Trojan et al, 2014). Children who had asthma were reported to have more depressive and anxious symptoms when compared to children who did not have asthma (Friedman, 2007; Meuret, Ehrenreich, Pincus, & Ritz, 2006).…”

Section: Introductionmentioning

confidence: 99%

Exploration of the Influence of Factors Identified in the Literature on School-aged Children's Emotional Responses to Asthma

Walker

2017

Journal of Pediatric Nursing

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Approximately 6.3 million US children suffer from asthma. The purpose of this study was to explore factors on school-aged children’s emotional responses to asthma, N=85, ages 6–12. Correlations included Asthma related child emotional functioning QOL and (a) asthma severity, r = −.30, p <.01, (b) child internalizing behaviors, r = −.26, p < .05, (c) child externalizing behaviors r = −.43, p <.001; Caregiver emotional functioning QOL and (a) asthma severity, r = −.39, p <.001, (b) child internalizing behaviors, r = −.22, p < .05, (c) child externalizing behaviors, r = −.25; p < .05. Multiple regression analysis revealed that asthma severity and child externalizing problems accounted for 26% of the variance in asthma related child emotional functioning QOL, F (4, 79) = 7.051, p < .001(asthma severity, β = − .31, p < .01; child externalizing problem behaviors, β = − .43, p < .001). Findings imply that asthma research should consider problem behaviors of school-aged children when addressing asthma related emotional functioning QOL.

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Asthma and depression: the Cooper Center Longitudinal Study

Cited by 36 publications

References 46 publications

Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

Proteomic analysis of sputum reveals novel biomarkers for various presentations of asthma

Cough variant asthma patients are more depressed and anxious than classic asthma patients

Exploration of the Influence of Factors Identified in the Literature on School-aged Children's Emotional Responses to Asthma

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