Asthma Improved by Acetylsalicylic Acid and Other Nonsteroidal Anti-Inflammatory Agents

Nelson, Robert P.; Stablein, John J.; Lockey, Richard F.

doi:10.2500/108854186779047717

Cited by 17 publications

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“…The mechanism(s) involved in ASA desensitization is only partially understood. In the acute phase (the 1st hours after ASA exposure), aspirin is thought to cause down-regulation of LTE 4 receptors in the airway, 19 causing a decrease in airway hyperreactivity, although tissue leukotriene levels remain high. In the chronic phase (after ≥2 weeks of treatment), 13 there is a drop in the tissue levels of the leukotrienes B 4 and LTE 4 , 23,24 and this also contributes to a reduction in upper and lower airway hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

“…Several subsequent studies have shown the efficacy of ASA desensitization in improving asthma and nasal symptoms in CRSwP patients, with treatment discontinuation resulting in rapid resensitization within days. [18][19][20][21][22] The aim of this study was to prospectively measure nasal and blood inflammatory markers (nasal cell count, LTE 4 , tryptase, albumin, and prostaglandin E 2 [PGE 2 ]) and correlate the findings with nasal and bronchial symptoms during the period of aspirin desensitization.…”

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confidence: 99%

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Aspirin Challenge in Patients with Chronic Rhinosinusitis with Polyps Correlates with Local and Systemic Inflammatory Markers

Forer

Landsberg

Kivity

2013

Am J Rhinol�Allergy

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

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confidence: 99%

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Aspirin Challenge in Patients with Chronic Rhinosinusitis with Polyps Correlates with Local and Systemic Inflammatory Markers

Forer

Landsberg

Kivity

2013

Am J Rhinol�Allergy

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“…Another interesting phenomenon of aspirin sensitivity is the fact that there is a subgroup of patients whose asthma is benefited by aspirin [57,58]. The numbers of individuals who demonstrate this effect are small and confined largely to case reports.…”

Section: Other Agents and Approachesmentioning

confidence: 98%

The mechanisms of aspirin-intolerant asthma and its management

McGeehan

Bush

2002

Curr Allergy Asthma Rep

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Aspirin is one of the most widely used medications in the world. Adverse effects related to aspirin use were described almost concurrently with its first use. The most common side effects are gastrointestinal and renal, but adverse respiratory effects are not uncommon, and approximately 10% of adult asthmatics are aspirin intolerant. Many of these patients present with the so-called aspirin triad of aspirin sensitivity, chronic rhinosinusitis with associated nasal polyposis, and severe asthma. This paper provides a review of recent investigations into the pathogenesis of this process, which have furthered our understanding of the mechanisms and management of aspirin-induced asthma.

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“…Desensitization to aspirin was first described as a means of enabling its use for treating asthma in ASA-sensitive patients (9) . Since then, several studies have demonstrated the efficacy of ASA desensitization in improving asthma and nasal symptoms in ASA triad patients (10)(11)(12) . Desensitization is performed by giving incremental doses of aspirin in a hospital setting and then monitoring airway function.…”

Section: Introductionmentioning

confidence: 99%

Aspirin desensitization for ASA triad patients--prospective study of the rhinologist's perspective

Forer

Kivity²,

Sade³

et al. 2011

Rhin

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OBJECTIVES/PROBLEM: To determine the sinonasal effect of aspirin salicylic acid (ASA) desensitization in patients with nasal polyps, asthma and aspirin intolerance (ASA triad). METHODS OF STUDY: Patients with ASA triad were recruited from the outpatient otolaryngology clinic. They underwent a program of ASA desensitization (2005 - 2008) with prospective assessment of subjective and objective responses. Incremental doses of aspirin were given to reach a target of 625 mg twice daily during a period of 3 - 5 days. A maintenance dose was then given for the study period. The patients also received inhaled and topical nasal steroids, antihistamines and beta agonists for asthma control, but no systemic steroid treatment. MAIN RESULTS: Of the original 27 enrolled subjects, 10 elected to discontinue treatment and five dropped out because of treatment complications. The objective evaluation of the polypoid sinonasal disease in the remaining 12 patients (4 males, 8 females, age range 22 - 63 years) revealed only mild improvement. In contrast, the patients` subjective feeling of nasal congestion, nasal discharge and overall discomfort improved significantly. CONCLUSIONS: Aspirin desensitization has a favorable subjective effect on certain nasal symptoms among ASA triad patients, but the objective effect on polypoid mass is not significant.

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Asthma Improved by Acetylsalicylic Acid and Other Nonsteroidal Anti-Inflammatory Agents

Cited by 17 publications

References 0 publications

Aspirin Challenge in Patients with Chronic Rhinosinusitis with Polyps Correlates with Local and Systemic Inflammatory Markers

Aspirin Challenge in Patients with Chronic Rhinosinusitis with Polyps Correlates with Local and Systemic Inflammatory Markers

The mechanisms of aspirin-intolerant asthma and its management

Aspirin desensitization for ASA triad patients--prospective study of the rhinologist's perspective

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