Asthma is inversely associated with Helicobacter pylori status

Arram, Eman O.; Shahin, Doaa; Sherif, Mohamed Ahmed

doi:10.1016/j.ejcdt.2012.10.009

Cited by 5 publications

(5 citation statements)

References 33 publications

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“…The obtained results are compatible with several other studies in which an inverse correlation between H. pylori anti-bodies and asthma has been revealed. For instance, results obtained by Arram et al pointed out that there is a significant difference in H. pylori infection in asthmatic patients compared with the control group ( 9 ). The study of Chen and Blaser indicated that H. pylori infection could significantly reduce the risk of asthma and emphasized that performing more researches in order to orientate the exact mechanisms of action are necessary ( 5 ).…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan

Khamechian

Movahedian

Eskandari

et al. 2015

Jundishapur J Microbiol

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Background:Asthma is a chronic inflammatory air-way disease with increasing prevalence rate during the recent years. There are studies about the relationship between asthma and infectious diseases, including the association between asthma and Helicobacter pylori. According to the latest studies, there is an epidemiological correlation between asthma prevalence and prevalence of H. pylori.Objectives:The aim of this research was to study the correlation between H. pylori and asthma by biopsy in five to eighteen year-old children who had undergone endoscopy at Shahid Beheshti Hospital.Patients and Methods:Three hundred children (5 to 18 years old) undergoing endoscopy owing to gastro-intestinal problems at Shahid Beheshti Hospital were observed for childhood asthma using the Gina 2010 questionnaire which included 24 questions with “yes” and “no” answers to identify asthmatic patients with five positive answers. Next, the patients were referred to an allergy and asthma specialist for clinical examinations, spirometry and post bronchodilator test (Post BD).Results:Among 138 H. pylori positive patients, eight cases (5.8 %) were asthmatic while of the 162 H. pylori negative patients 28 (17.3%) were asthmatic. This difference was statistically significant (P Value = 0.002). The correlation between H. pylori and asthma was studied after controlling the confounding variables including, gender, age and family history. The results obtained for the above-mentioned variables were significant (P Values of 0.004, 0.005 and 0.002, and Odd-Ratio Mantel Haenszel (ORMH) of 3.38, 3.24 and 4.06, respectively).Conclusions:Our findings showed that there is an inverse correlation between H. pylori and asthma. Performing more studies with larger sample sizes is necessary to confirm these results.

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Section: Discussionmentioning

confidence: 99%

“…It is assumed that childhood asthma is more common in modern capitals and crowded nations and correlates extremely with other allergic reactions ( 9 ). In comparison, there is less possibility for children who live in rural areas of developing countries to become asthmatic ( 10 ).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan

Khamechian

Movahedian

Eskandari

et al. 2015

Jundishapur J Microbiol

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“…Similarly, HP-NAP inhibits the development of asthma through stimulation of Th1mediated immunity and inhibition of Th2-mediated immunity. H. pylori may influence Th2-mediated immune responses as well by upregulating Treg cells [31][32][33][34].…”

Section: Asthmamentioning

confidence: 99%

An overview of Helicobacter pylori infections, diagnostic methods and treatment

Mohammadi,

Omidi,

Mohsenzadeh

et al. 2023

Reviews and Research in Medical Microbiology

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Background: Helicobacter pylori is one of the most common infectious diseases in the world, causing peptic ulcers and gastric cancer in humans. Methods: Here, we used the words ‘Helicobacter pylori’, ‘identification’ and ‘treatment’ from the published data in PubMed, Scopus, and Google Scholar databases for this study. Results: Methods of identification of H. pylori are divided into two categories: invasive and noninvasive. Invasive methods detect bacteria directly from gastric biopsy, but noninvasive methods examine different samples. The key to effective treatment for H. pylori infection is the use of combination therapy, similar to the treatment for bacterial meningitis or endocarditis. Although alternative therapies, including herbal remedies and probiotics, have been used to improve eradication, current treatments still rely on a combination of antimicrobial agents such as amoxicillin, clarithromycin, metronidazole, and levofloxacin, as well as antisecretory agents such as proton pump inhibitors. Conclusion: Both invasive and noninvasive diagnostic methods identify H. pylori. Combination therapies are more efficient in eradicating the bacterium.

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“…The disappearance of Helicobacter pylori has been correlated with an increase in several diseases including allergy [ 26 , 27 ], asthma [ 26 , 28 ] and gastroesophageal reflux disease (GERD) [ 29 ]. It is believed to be related to immunological changes with the eradication of H .…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Serum Celiac Antibodies in a Multiracial Asian Population-A First Study in the Young Asian Adult Population of Malaysia

et al. 2015

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BackgroundCeliac disease (CD) is an immune-mediated disorder induced by the ingestion of gluten in genetically susceptible persons. The prevalence of CD in Malaysia is unknown. We aim to determine the seroprevalence of CD antibodies and also investigate the correlation between H. pylori infection and CD in the young and healthy multiracial Malaysian population.MethodsHealthy young adult volunteers between the ages of 18–30 years were consecutively recruited from June 2012 to May 2014 at the University of Malaya Medical Centre (UMMC), Kuala Lumpur. Serum samples from all the participants were tested for anti-gliadin antibody immunoglobulin A/immunoglobulin G (IgA/IgG) and anti-tissue transglutaminase antibody (tTG) IgA/IgG. Samples positive for both anti-gliadin and anti-tTG were further validated for anti-human endomysial IgA antibodies (EmA). Serological diagnosis of CD was made when anti-gliadin, anti-tTG and anti-EmA were positive.Results562 qualified participants with mean age 24 ± 2.4 years old were recruited into our study. CD was found in 7 participants where most of them were asymptomatic and unaware of their CD status. The median of anti-gliadin and anti-tTG IgA/IgG value was 38.2 U/ml (interquartile range, 28.3–60.4 U/ml) and 49.2 U/ml (interquartile range, 41.1–65.9 U/ml), respectively. Seroprevalence of CD antibodies was 1.9% (6 out of 324) in female while only 0.4% (1 out of 238) in male. Seroprevalence among Malay was 0.8% (2 of 236), Chinese was 1.7% (3 of 177) and Indian was 1.3% (2 of 149). Overall, seroprevalence of CD antibodies in healthy asymptomatic adults in the Malaysian population was 1.25% (95% CI, 0.78%-1.72%). No significant relationship was discovered between CD and H. pylori infection.ConclusionsThe seroprevalence of CD antibodies in healthy young adults in the Malaysian population was 1.25% (1 in 100). CD is underdiagnosed and it could be a much greater problem in Malaysia than previously thought.

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Asthma is inversely associated with Helicobacter pylori status

Cited by 5 publications

References 33 publications

Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan

Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan

An overview of Helicobacter pylori infections, diagnostic methods and treatment

Prevalence of Serum Celiac Antibodies in a Multiracial Asian Population-A First Study in the Young Asian Adult Population of Malaysia

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