Asthma: Pharmacological degradation of the airway smooth muscle layer

Wang, Kimberley C. W.; Donovan, Graham M.; Noble, Peter B.

doi:10.1016/j.biocel.2020.105818

Cited by 15 publications

(8 citation statements)

References 64 publications

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“…Despite airway remodeling, especially the increased ASM mass, being a major contributor to airway obstruction in asthma, it is not a consistent consideration in clinical decisions related to therapeutic interventions 50 . This study was performed to investigate whether modulation of ASM biology by macrolides contribute to their clinical efficacy.…”

Section: Discussionmentioning

confidence: 99%

Effects of azithromycin on bronchial remodeling in the natural model of severe neutrophilic asthma in horses

Mainguy-Seers

Boivin

Dogaheh

et al. 2022

Sci Rep

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Steroid resistance in asthma has been associated with neutrophilic inflammation and severe manifestations of the disease. Macrolide add-on therapy can improve the quality of life and the exacerbation rate in refractory cases, possibly with greater effectiveness in neutrophilic phenotypes. The mechanisms leading to these beneficial effects are incompletely understood and whether macrolides potentiate the modulation of bronchial remodeling induced by inhaled corticosteroids (ICS) is unknown. The objective of this study was to determine if adding azithromycin to ICS leads to further improvement of lung function, airway inflammation and bronchial remodeling in severe asthma. The combination of azithromycin (10 mg/kg q48h PO) and inhaled fluticasone (2500 µg q12h) was compared to the sole administration of fluticasone for five months in a randomized blind trial where the lung function, airway inflammation and bronchial remodeling (histomorphometry of central and peripheral airways and endobronchial ultrasound) of horses with severe neutrophilic asthma were assessed. Although the proportional reduction of airway neutrophilia was significantly larger in the group receiving azithromycin, the lung function and the peripheral and central airway smooth muscle mass decreased similarly in both groups. Despite a better control of airway neutrophilia, azithromycin did not potentiate the other clinical effects of fluticasone.

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Section: Discussionmentioning

confidence: 99%

Effects of azithromycin on bronchial remodeling in the natural model of severe neutrophilic asthma in horses

Mainguy-Seers

Boivin

Dogaheh

et al. 2022

Sci Rep

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“…The good news is that this should in theory be a testable hypothesis; directly assess airway structure at birth and track its association with future disease. Concrete data on the kinetics of ASM remodelling should inform strategies for disease mitigation and possibly pharmacological ablation of the ASM layer, proposed in our recent review (91).…”

Section: Future Avenues For Studymentioning

confidence: 98%

Fetal Growth Restriction and Asthma: Is the Damage Done?

Wang

Noble

2021

Physiology

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Trajectories of airway remodeling and functional impairment in asthma are consistent with the notion that airway pathology precedes or coincides with the onset of asthma symptoms and may be present at birth. An association between intrauterine growth restriction (IUGR) and asthma development has also been established, and there is value in understanding the underlying mechanism. This review considers airway pathophysiology as a consequence of IUGR that increases susceptibility to asthma.

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“…The question of how best to normalize airway measurements, and accompanying analysis, is far from a scientific niche. The need for direct and accurate measurement of ASM dimensions has been proposed to expand treatment of asthma, 9,10 optimize current approaches 11,12 and to add an additional dimension to patient phenotyping 13 . Specifically, newer in vivo approaches such as polarization‐sensitive optical coherence tomography are being developed for identifying and mapping ASM remodelling, 14 and will require an effective normalization method for airway size.…”

Section: Figurementioning

confidence: 99%