Asthma research in <scp>C</scp>hina: A five‐year review

Chen, Zhihua; Wang, Pingli; Shen, Huahao

doi:10.1111/resp.12196

Cited by 36 publications

(28 citation statements)

References 82 publications

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“…They received a copy of their written personal walking action plan, their personal SNAPPS summary, plus information concerning health behaviors (Supplementary material). Participants were contacted via telephone by specifically trained community nurses19,20,33 who acted as nurse health-mentors over the next 8–12 weeks, to support the home-walking action plan and any other health behavior plans. A schedule of two calls weekly was suggested, with a minimum of four calls mutually agreed with each participant, based on findings in a previous study that indicated participants preferred a flexible schedule for health-mentoring contacts 20…”

Section: Methodsmentioning

confidence: 99%

A randomized controlled trial of telephone-mentoring with home-based walking preceding rehabilitation in COPD

Cameron-Tucker¹,

Wood‐Baker²,

Joseph³

et al. 2016

COPD

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PurposeWith the limited reach of pulmonary rehabilitation (PR) and low levels of daily physical activity in chronic obstructive pulmonary disease (COPD), a need exists to increase daily exercise. This study evaluated telephone health-mentoring targeting home-based walking (tele-rehab) compared to usual waiting time (usual care) followed by group PR.Patients and methodsPeople with COPD were randomized to tele-rehab (intervention) or usual care (controls). Tele-rehab delivered by trained nurse health-mentors supported participants’ home-based walking over 8–12 weeks. PR, delivered to both groups simultaneously, included 8 weeks of once-weekly education and self-management skills, with separate supervised exercise. Data were collected at three time-points: baseline (TP1), before (TP2), and after (TP3) PR. The primary outcome was change in physical capacity measured by 6-minute walk distance (6MWD) with two tests performed at each time-point. Secondary outcomes included changes in self-reported home-based walking, health-related quality of life, and health behaviors.ResultsOf 65 recruits, 25 withdrew before completing PR. Forty attended a median of 6 (4) education sessions. Seventeen attended supervised exercise (5±2 sessions). Between TP1 and TP2, there was a statistically significant increase in the median 6MWD of 12 (39.1) m in controls, but no change in the tele-rehab group. There were no significant changes in 6MWD between other time-points or groups, or significant change in any secondary outcomes. Participants attending supervised exercise showed a nonsignificant improvement in 6MWD, 12.3 (71) m, while others showed no change, 0 (33) m. The mean 6MWD was significantly greater, but not clinically meaningful, for the second test compared to the first at all time-points.ConclusionTelephone-mentoring for home-based walking demonstrated no benefit to exercise capacity. Two 6-minute walking tests at each time-point may not be necessary. Supervised exercise seems essential in PR. The challenge of incorporating exercise into daily life in COPD is substantial.

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Section: Methodsmentioning

confidence: 99%

A randomized controlled trial of telephone-mentoring with home-based walking preceding rehabilitation in COPD

Cameron-Tucker¹,

Wood‐Baker²,

Joseph³

et al. 2016

COPD

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“…For instance, it has been suggested previously that the 589 C/T variant in the IL-4 promoter region is connected to decreased FEV1 (Lee et al, 2004). Such relationships have been confirmed in populations in Japan and the USA (Nambu and Holgate, 2009;Zahran and Bailey, 2013), but not China and Arabia (Al-Mazam and Mohamed, 2001;Chen et al, 2013). The IL-4 and IL-13 genes are located on chromosome 5q31, a site potentially linked to atopic asthma.…”

Section: Discussionmentioning

confidence: 91%

Role of interleukin-4 genetic polymorphisms and environmental factors in the risk of asthma in children

Zeng

et al. 2016

Genet. Mol. Res.

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ABSTRACT. Asthma is an allergic disease characterized by hyperresponsiveness and chronic inflammation of the airway. The interleukin-4 (IL-4) gene and its single nucleotide polymorphisms are associated with asthma susceptibility in children. A case-control study was performed to evaluate the relationship between asthma risk and the IL-4 rs2243250 (589 C/T) and rs2070874 (107 T/C), and IL-4 receptor (IL-4R) rs1801275 (576 Q/R) polymorphisms in 317 childhood asthma patients and 351 healthy children as controls. Polymerase chain reaction amplification and sequencing was performed. The effects of interactions between the genes of interest and environmental factors were also analyzed. IL-4 rs2243250 and rs2070874 allele and genotype frequencies did not significantly differ between the asthma and control groups (P > 0.05), but those of IL-4R rs1801275 did (P < 0.05). The RR genotype and R allele of this IL-4R variant were significantly associated with asthma risk, with odds ratios (ORs; and 95% confidence intervals) of 2.97 (2.08-4.25) and 2.99 (2.32-3.85), respectively. Logistic regression analysis showed that the IL-4R 576 Q/R RR genotype demonstrated a positive interaction with environments associated with smoking or pets in its effect on asthma risk, with ORs of 2.18 (P = 0.02) and 2.29 (P = 0.01), respectively. Our results suggest that the IL-4R rs1801275 polymorphism is associated with childhood asthma, and the RR genotype confers a high risk of developing this condition. This variant exhibited positive interactions with environments in which smoking or pets were present in increasing the risk of childhood asthma.

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“…In China, the asthma population has reached 30 million [2]. The prevalence of asthma tends to be higher in urbanized and well-developed areas compared to the developing areas ([3]; Weiland and Pearce, 2004).…”

Section: Introductionmentioning

confidence: 99%

Markov Chain-Based Acute Effect Estimation of Air Pollution on Elder Asthma Hospitalization

Luo

Zhang

et al. 2017

Journal of Healthcare Engineering

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Background Asthma caused substantial economic and health care burden and is susceptible to air pollution. Particularly, when it comes to elder asthma patient (older than 65), the phenomenon is more significant. The aim of this study is to investigate the Markov-based acute effects of air pollution on elder asthma hospitalizations, in forms of transition probabilities. Methods A retrospective, population-based study design was used to assess temporal patterns in hospitalizations for asthma in a region of Sichuan province, China. Approximately 12 million residents were covered during this period. Relative risk analysis and Markov chain model were employed on daily hospitalization state estimation. Results Among PM2.5, PM10, NO2, and SO2, only SO2 was significant. When air pollution is severe, the transition probability from a low-admission state (previous day) to high-admission state (next day) is 35.46%, while it is 20.08% when air pollution is mild. In particular, for female-cold subgroup, the counterparts are 30.06% and 0.01%, respectively. Conclusions SO2 was a significant risk factor for elder asthma hospitalization. When air pollution worsened, the transition probabilities from each state to high admission states increase dramatically. This phenomenon appeared more evidently, especially in female-cold subgroup (which is in cold season for female admissions). Based on our work, admission amount forecast, asthma intervention, and corresponding healthcare allocation can be done.

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Asthma research in China: A five‐year review

Cited by 36 publications

References 82 publications

A randomized controlled trial of telephone-mentoring with home-based walking preceding rehabilitation in COPD

A randomized controlled trial of telephone-mentoring with home-based walking preceding rehabilitation in COPD

Role of interleukin-4 genetic polymorphisms and environmental factors in the risk of asthma in children

Markov Chain-Based Acute Effect Estimation of Air Pollution on Elder Asthma Hospitalization

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