Asthma‐<scp>COPD</scp> overlap syndrome—Coexistence of chronic obstructive pulmonary disease and asthma in elderly patients and parameters for their differentiation

Tochino, Yoshihiro; Asai, Kuniya; Shuto, Taichi; Hirata, Kazuto

doi:10.1002/jgf2.2

J of Gen and Family Med

2017

DOI: 10.1002/jgf2.2

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Asthma‐COPD overlap syndrome—Coexistence of chronic obstructive pulmonary disease and asthma in elderly patients and parameters for their differentiation

Yoshihiro Tochino

Kuniya Asai

Taichi Shuto

et al.

Abstract: Japan is an aging society, and the number of elderly patients with asthma and chronic obstructive pulmonary disease (COPD) is consequently increasing, with an estimated incidence of approximately 5 million. In 2014, asthma‐COPD overlap syndrome (ACOS) was defined by a joint project of Global Initiative for Asthma (GINA) committee and the Global Initiative for Chronic Obstructive Lung Disease (GOLD) committee. The main aims of this consensus‐based document are to assist clinicians, especially those in primary c… Show more

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Cited by 10 publications

References 17 publications

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Rehabilitation nutrition in general and family medicine

Wakabayashi¹

2017

J of Gen and Family Med

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treat nutrition-related sarcopenia. Nutrition care management alone cannot treat activity-related sarcopenia. Therefore, a comprehensive approach to treatment of sarcopenia and sarcopenic dysphagia should include rehabilitation such as resistance training, early ambulation, early oral intake, and nutrition care management. I expect that many general and family physicians are interested in rehabilitation nutrition, sarcopenia, and sarcopenic dysphagia and prevent iatrogenic sarcopenia. CONFLICT OF INTEREST

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Rehabilitation nutrition in general and family medicine

Wakabayashi¹

2017

J of Gen and Family Med

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Effects of PM10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status

Lee

Kim

et al. 2020

Sci Rep

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We investigated the effects of particulate matter (PM) on mortality in patients diagnosed with asthma-COPD overlap (ACO) or ‘pure COPD’. Subjects from the National Health Insurance Service–National Sample Cohort of Korea, who were aged 40 years or above and had newly diagnosed COPD since 2009 were selected. Finally, 6,313 patients were enrolled and divided into ‘pure COPD’ and ACO groups. Average PM10 exposure data were obtained using Kriging interpolation from 2001 to 2013. Hazard ratios(HR) were estimated using a time-varying Cox regression model. Exposure to PM10 for 1, 3, and 6 months was associated with an increase in non-accidental mortality in the entire COPD group, especially the ACO group. When a stratified analysis of 3-month exposure was performed by sex, the highest HR was found in women with ACO (HR = 1.153; 95% confidence intervals [CI]: 1.121, 1.185). A stratified analysis according to smoking status showed that ACO patients had the highest HR among never smokers (HR = 1.151; 95% CI; 1.124, 1.178). Average exposure to PM10 was associated with non-accidental mortality in patients with COPD, especially those diagnosed with ACO. In addition, the adverse effects of PM10 exposure are more severe in women and never-smokers.

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Association of asthma–chronic obstructive pulmonary disease overlap syndrome with coronary artery disease, cardiac dysrhythmia and heart failure: a population-based retrospective cohort study

et al. 2017

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ObjectivesPatients with asthma–chronic obstructive pulmonary disease (COPD) overlap syndrome (ACOS) and cardiovascular diseases (CVDs) share common risk factors. However, the association between ACOS and the incidence of CVDs has not been reported. This study investigated the relationship between CVDs and ACOS in the general population.SettingData were obtained from Taiwan’s National Health Insurance Research Database for the period 2000 to 2010.ParticipantsThe ACOS cohort comprised patients (n=5814) who had received a diagnosis of asthma and COPD. The non-ACOS cohort comprised patients who had not received a diagnosis of asthma or COPD and were matched to the ACOS cohort (2:1) by age, sex and index date (n=11 625).Primary and secondary outcome measuresThe cumulative incidence of CVDs—coronary artery disease (CAD), cardiac dysrhythmia (CD) and heart failure (HF)—was calculated. Cox proportional regression analysis was employed to examine the relationship between ACOS and CVDs.ResultsAfter adjustment for multiple confounding factors—age, sex, comorbidities and medications—patients with ACOS were associated with a significantly higher risk of CVDs; the adjusted HRs (aHRs; 95% CI) for CAD, CD and HF were 1.62 (1.50 to 1.76), 1.44 (1.30 to 1.61) and 1.94 (1.73 to 2.19), respectively, whereas those of beta-blockers treatment for CAD, CD and HF were 1.19 (0.92 to 1.53), 0.90 (0.56 to 1.45) and 0.82 (0.49 to 1.38). The aHR of atenolol treatment for CD was 1.72 (1.01 to 2.93). The aHRs (95% CIs) of ACOS without acute exacerbation of COPD (AE-COPD) for CAD, CD and HF were 1.85 (1.70 to 2.01), 1.57 (1.40 to 1.77) and 2.07 (1.82 to 2.35), respectively.ConclusionACOS was associated with higher CVD risk, even without the presence of previous comorbidities or AE-COPD. No significant differences in CVD events were observed in the ACOS cohort using beta-blockers, except for those using atenolol for treating CD.

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Asthma‐COPD overlap syndrome—Coexistence of chronic obstructive pulmonary disease and asthma in elderly patients and parameters for their differentiation

Cited by 10 publications

References 17 publications

Rehabilitation nutrition in general and family medicine

Rehabilitation nutrition in general and family medicine

Effects of PM10 on mortality in pure COPD and asthma-COPD overlap: difference in exposure duration, gender, and smoking status

Association of asthma–chronic obstructive pulmonary disease overlap syndrome with coronary artery disease, cardiac dysrhythmia and heart failure: a population-based retrospective cohort study

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