Asthmatic symptoms after exposure to ethylenebisdithiocarbamates and other pesticides in the Europit field studies

Boers, D.; Amelsvoort, L.G.P.M. van; Colosio, Claudio; Corsini, Emanuela; Fustinoni, Silvia; Campo, Laura; Bosetti, Cristina; Vecchia, Carlo La; Vergieva, T; Tarkowski, Maciej; Liesivuori, Jyrki; Steerenberg, Peter S.; Loveren, Henk Van

doi:10.1177/0960327108100001

Cited by 15 publications

(12 citation statements)

References 24 publications

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“…No association was observed with the diagnosis of asthma (OR 1.19, 95% CI 0.93-1.52) or the occurrence of asthma attacks (OR 1.14, 95% CI 0.72-1.80) and urinary levels of ethylene thiourea, a metabolite of dithicarbamate fungicides [57].…”

Section: Wheeze and Asthmamentioning

confidence: 79%

Occupational exposure to pesticides and respiratory health

et al. 2015

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This article aims to review the available literature regarding the link between occupational exposure to pesticides and respiratory symptoms or diseases. Identification of epidemiological studies was performed using PubMed. 41 articles were included, 36 regarding agricultural workers and five regarding industry workers.Among the 15 cross-sectional studies focusing on respiratory symptoms and agricultural pesticide exposure, 12 found significant associations with chronic cough, wheeze, dyspnoea, breathlessness or chest tightness. All four studies on asthma found a relationship with occupational exposure, as did all three studies on chronic bronchitis. The four studies that performed spirometry reported impaired respiratory function linked to pesticide exposure, suggestive of either obstructive or restrictive syndrome according to the chemical class of pesticide.12 papers reported results from cohort studies. Three out of nine found a significant relationship with increased risk of wheeze, five out of nine with asthma and three out of three with chronic bronchitis. In workers employed in pesticide production, elevated risks of chronic obstructive pulmonary disease (two studies out of three) and impaired respiratory function suggestive of an obstructive syndrome (two studies out of two) were reported.In conclusion, this article suggests that occupational exposure to pesticides is associated with an increased risk of respiratory symptoms, asthma and chronic bronchitis, but the causal relationship is still under debate. @ERSpublications A review of occupational (agricultural and industry) exposure to pesticides and associated respiratory health effects http:///ow.ly/M09Gc

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Section: Wheeze and Asthmamentioning

confidence: 79%

Occupational exposure to pesticides and respiratory health

et al. 2015

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“…Only one study in adults employed pesticide biomonitoring and this failed to find an association with asthma and ethylenebisdithiocarbamate exposed workers [16].…”

Section: Resultsmentioning

confidence: 99%

“…Most studies relied on questionnaires to characterise likely exposures; an approach that can be vulnerable to recall bias and exposure misclassification. Relatively few studies employed biomonitoring to measure pesticide exposure [16,28,32] or biological effect monitoring [17]. A particular issue arose for those studies in agricultural settings where self-reports of pesticide exposure were used, but co-exposures to other agricultural respiratory hazards (e.g.…”

Section: Limitations Of Included Papersmentioning

confidence: 99%

Is pesticide exposure a cause of obstructive airways disease?

et al. 2014

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A systematic review was performed to identify any associations between pesticide exposure and the occurrence (both prevalence and incidence) of airways disease (asthma and chronic obstructive pulmonary disease) and wheezing symptoms.PubMed, MEDLINE, Embase, Scopus, CINAHL, Google Scholar and the Cochrane Database of Systematic Reviews were searched between September 2010 and October 2010 for papers with the inclusion criteria of English language, published after 1990, peer-reviewed and nondietary exposure. From a total of 4390 papers identified, 42 were included after initial assessment of content. After evaluating the included studies for quality, those considered to be at high risk of bias were excluded, leaving a total of 23 relevant papers.Results suggest that exposure to pesticides may be associated with prevalent asthma, but methodological issues, such as cross-sectional/case-control design, measurements of exposure and limited adjustment for confounders, limit the strength of the evidence base in this area. The association between pesticide exposure and asthma appears to be more evident and consistent in children than in adults. Exposure to pesticides may be associated with COPD; however, the strength of evidence for an association with COPD is weaker than for asthma. As the exposure metrics within each health end-point varied across studies, no metaanalyses were carried out. @ERSpublications Pesticide exposure may be associated with increased respiratory symptoms; evidence is lacking on specific pesticides http://ow/ly/U5Qr7

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“…Immunoglobulin, complement, mitogen-induced cytokyines, mitogen-induced proliferative response, and lymphocyte subtypes were used to investigate for alterations in functions of the immune system in these workers. The EUROPIT field study showed no association between exposure to EBCDs and an increased prevalence of allergic contact dermatitis, allergic rhinitis, asthma and asthmatic symptoms, or IgE-mediated allergic response to selected antigens in these workers Boers et al, 2008). An increase in T-cell proliferative response to mitogens (phytohemagglutinin, anti-CD3 monoclonal antibody and phorbol myristate acetate) was observed in workers manufacturing EBDC (mancozeb) compared to controls (Colosio et al, 1996).…”

Section: Human Health Effectsmentioning

confidence: 93%