Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk

Ryu, Minsook; Kim, Eun Hye; Chun, Mison; Kang, Shin-Wook; Shim, Bum-Sang; Yu, Young-Beob; Jeong, Gajin; Lee, Jong-Soo

doi:10.1016/j.jep.2007.09.027

Cited by 149 publications

(77 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The probable mechanism of action of carrageenan induced edema is bi-phasic; the release of histamine, serotonin, 5-HT and kinins in the first phase; while swelling is related to the release of prostaglandin, bradykinins and lysozymes-like substances in 2-3 hrs, in the second phase (Di Rosa et al, 1971; Brooks and Day, 1991). The related species show the significant anti-inflammatory activities (Ryu et al, 2008). Reduction of carrageenan induced edema by AGHE and AGRE indicated the anti-inflammatory activity of this plant.…”

Section: Histopathological Studiesmentioning

confidence: 83%

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Yusufoğlu¹,

Alam²,

Zaghloul³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

Background: The Astragalus gummifer (F. Fabaceae), herb and roots were studied for anti-inflammatory and hepatoprotective activities. Materials and method:The alcoholic extracts of Astragalus gummifer (F. Fabaceae), herb (AGHE), and roots (AGRE), were used for antiinflammatory and hepatoprotective activities in Wister rats. The effects of AGHE and AGRE were compared with the standard drugs Phenylbutazone and silymarin, for anti-inflammatory and hepatoprotective activities respectively. Result: Both extracts showed significant anti-inflammatory activity (P< 0.001). AGRE showed comparatively more significant hepatoprotective activity (P< 0.001), than AGHE (P< 0.05); at doses of 250 and 500 mg/kg body weight as manifested by lowering the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), and total bilirubin. The hepatoprotective activity was, also, supported by total protein (TP), malondialdehyde (MDA), nonprotein sulfhydryls (NP-SH), and histo-pathological studies of liver tissue. Discussion: To the best of our knowledge, this is the first report of the anti-inflammatory and hepatoprotective activities of Astragalus gummifer.The results of present studies indicated that both AGHE and AGRE can be used in inflammatory conditions, while investigation supports the use of AGRE in cases that hepatoprotection are required in the hepatotoxic conditions. More supportive studies are required before clinical recommendation.

show abstract

Section: Histopathological Studiesmentioning

confidence: 83%

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Yusufoğlu¹,

Alam²,

Zaghloul³

et al. 2014

Afr. J. Trad. Compl. Alt. Med.

View full text Add to dashboard Cite

show abstract

“…However, the combination of the two agents resulted in signifi cant decreases in TNF-α at both 7d and 14d. Previous studies have found that both A. sinensis (Xie et al, 2006) and A. membranaceus (Ryu et al, 2008) reduce the expression of TNF-α in disorders involving infl ammation. Similarly, studies administering ACEi treatment in UUO animals have found decreases in TNF-α levels of the obstructed kidneys early in the course of UUO (el-Dahr et al, 1993;Guo et al, 2001;Moridaira et al, 2003), but not after 5 days or more (Guo et al, 2001).…”

Section: Discussionmentioning

confidence: 94%

Effect of Astragalus membranaceus and Angelica sinensis combined with Enalapril in rats with obstructive uropathy

Wojcikowski

Wohlmuth

Johnson

et al. 2010

Phytotherapy Research

View full text Add to dashboard Cite

ACE inhibitors (ACEi) reduce renal tubulointerstitial fibrosis but are not completely effective. Combined extract of Astragalus membranaceus and Angelica sinensis (A&A) is a traditional antifibrotic agent in China. The present investigation aimed to determine whether an ACEi (Enalapril) and A&A together have a better antifibrotic effect in unilateral ureteral obstruction (UUO) than monotherapy with either agent. Male Sprague-Dawley rats (N = 4 per group) had either sham operation or UUO alone, with A&A (combined aqueous and ethanol extract equivalent to 2.1 g dried herbs), with Enalapril (in drinking water at 200 mg/mL) or with both treatments. Kidney and liver were collected for protein extraction or fixed for histologic stains, immunohistochemistry (IHC), microscopy. Enalapril or A&A individually were antifibrotic. Transforming growth factor-beta1, fibroblast activation, collagen deposition, macrophage accumulation and tubular cell apoptosis were all decreased. The combination of the two drugs was significantly more effective than Enalapril alone in reducing tumor necrosis factor-alpha, collagen accumulation, activation of fibroblasts, and tubular cell apoptosis. In conclusion, Enalapril with A&A significantly decreased tubulointerstitial fibrosis to a greater extent than treatment with Enalapril alone. Further studies focusing on the isolation of the active constituents of A&A and the clinical application of the combination of ACEi plus A&A are warranted to determine the value of this treatment in humans.

show abstract

“…The root of Astragalus species is known to be rich in polysaccharides, saponins, flavonoids, amino acids, and trace elements, which have been regarded as a potent tonic for increasing energy levels and stimulating the immune system (Wang et al 2002;Block and Mead 2003) and has been shown to increase human lymphocyte proliferation, cytotoxic T-cell responses, and IgG production (Ma et al 2002a, b). It has potential antiinflammatory (Ryu et al 2008) and anticancer effects (Auyeung et al 2009). Astragalus polysaccharides and astragalosides showed strong promoting effects on the phagocytosis of Mycobacterium tuberculosis and on the secretion of interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha by activated macrophages from mice (Xu et al 2007).…”

Section: Flavonoidsmentioning

confidence: 99%

Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

Lü

2013

Parasitology Research Monographs

View full text Add to dashboard Cite

Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis, a widespread infection, with clinical spectrum ranging from a completely asymptomatic infection to multiorgan involvement. Novel medicines effective against both active and latent forms of the parasite are greatly needed. To review current evidence for antitoxoplasmosis by Traditional Chinese Medicine (TCM), our literature focused on five kinds of Chinese herbs, including Torilis japonica, Zingiber officinale, Sophora flavescens, Astragalus membranaceus, and Scutellaria baicalensis GEORGI in our present study, which are used in TCM for the treatment of allergic inflammatory diseases, infectious diseases such as bacterial infection, virus infection, helminthiasis, etc., and the mentioned TCM whose antiapicomplexan activity have been previously reported. In conclusion, TCM possess promising activity in vivo and in vitro against T. gondii, and the components of TCM deserve further study.

show abstract

Astragali Radix elicits anti-inflammation via activation of MKP-1, concomitant with attenuation of p38 and Erk

Cited by 149 publications

References 43 publications

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Comparative Anti-Inflammatory and Hepatoprotective Activities of <i>Astragalus Gummifer</i> Labill Herb and Roots in Rats

Effect of Astragalus membranaceus and Angelica sinensis combined with Enalapril in rats with obstructive uropathy

Treatment Methods of Traditional Chinese Medicine for Toxoplasmosis

Contact Info

Product

Resources

About