Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine

Chen, Zhejie; Liu, Lijuan; Gao, Chenlin; Chen, Weijie; Vong, Chi Teng; Yao, Peifen; Yang, Yuhan; Li, Xiuzhu; Tang, Xudong; Wang, Shengpeng; Wang, Ying

doi:10.1016/j.jep.2020.112895

Cited by 214 publications

(123 citation statements)

References 117 publications

Supporting

Mentioning

122

Contrasting

Unclassified

Order By: Relevance

“…The preliminary research of the research group confirmed [ 4 , 5 ] that the formula can promote the metabolism and absorption of extracellular matrix such as collagen fibers and then alleviate the development of PF. Modern pharmacological studies have found that most of Chinese medicine in YFSJF can alleviate PF by improving autoimmune function [ 6 ], relieving excessive inflammation, inhibiting apoptosis, and reducing collagen deposition [ 7 ]. However, the specific mechanism needs to be further studied.…”

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

Qiao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective. Yifei Sanjie Formula (YFSJF) is an effective formula on pulmonary fibrosis (PF), which has been used in clinic for more than 30 years. In order to investigate the molecular mechanism of YFSJF in treating PF, network pharmacology was used to predict the cooperative ingredients and associated pathways. Methods. Firstly, we collected potential active ingredients of YFSJF by TCMSP databases. Secondly, we obtained PF-associated targets through OMIM and Genecards database. Finally, metascape was applied for the analysis of GO terms and KEGG pathways. Results. We screened out 76 potential active ingredients and 98 associated proteins. A total of 5715 items were obtained by GO enrichment analysis ( P < 0.05 ), including 4632 biological processes, 444 cellular components, and 639 molecular functions. A total of 143 related KEGG pathways were enriched ( P < 0.05 ), including IL-17 signaling pathway, T cell receptor signaling pathway, TNF signaling pathway, calcium signaling pathway, TH17 cell differentiation, HIF-1 signaling pathway, and PI3K-Akt signaling pathway. Conclusion. YFSJF can interfere with immune and inflammatory response through multiple targets and pathways, which has a certain role in the treatment of PF. This study lays a foundation for future experimental research.

show abstract

Section: Introductionmentioning

confidence: 99%

A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

Qiao

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

show abstract

“…After treatment with 1.0 mg/ml APS, toll-like receptor (TLR) 4, myeloid differentiation primary response gene 88 (MyD88), and nuclear factor-κB (NF-κB) mRNA expression levels in the macrophages were significantly reduced (p < 0.05). Therefore, APS can be used to improve the morphology of macrophages, to restore cell proliferation, to reduce the secretion of pro-inflammatory factors, and to attenuate the immune stress response by regulating the expression of genes related to the TLR4 signaling pathway (Chen Z. et al, 2020). Additionally, one clinical trial investigated the effect of APS injection on the inflammatory cell count and the levels of related factors in 196 patients with bronchial asthma.…”

Section: Bioactive Components Of Plant-based Functional Foods and Their Immune-boosting Effects Polysaccharidesmentioning

confidence: 99%

“…For example, previous studies have reported that active polysaccharides obtained from Ganoderma may evoke an immune defense response against tumor growth, viruses, bacteria, and fungal pathogens via modulation of lymphocytes and myeloid cells, thereby indicating a potential application for the modulation of the host immune system (Ren et al, 2020). Furthermore, astragalus, ginseng, and Ophiocordyceps sinensis have also been reported to exhibit appreciable immune enhancement effects (Chen and Zhan, 2019;Huang et al, 2019;Kim et al, 2019;Chen Z. et al, 2020). In general, the active ingredients of plant functional foods that enhance immunity mainly include polysaccharides, saponins, flavonoids, alkaloids.…”

Section: Introductionmentioning

confidence: 99%

Potential Application of Plant-Based Functional Foods in the Development of Immune Boosters

Jiang

Zhang

et al. 2021

Front. Pharmacol.

View full text Add to dashboard Cite

Immune dysfunction, which is responsible for the development of human diseases including cancer, is caused by a variety of factors. Therefore, regulation of the factors influencing the immune response is a potentially effective strategy to counter diseases. Presently, several immune adjuvants are used in clinical practice to enhance the immune response and host defense ability; however, synthetic drugs can exert negative side effects. Thus, the search for natural products of plant origin as new leads for the development of potent and safe immune boosters is gaining considerable research interest. Plant-based functional foods have been shown to exert several immunomodulatory effects in humans; therefore, the application of new agents to enhance immunological and specific host defenses is a promising approach. In this comprehensive review, we have provided an up-to-date report on the use as well as the known and potential mechanisms of bioactive compounds obtained from plant-based functional foods as natural immune boosters. Plant-based bioactive compounds promote immunity through multiple mechanisms, including influencing the immune organs, cellular immunity, humoral immunity, nonspecific immunity, and immune-related signal transduction pathways. Enhancement of the immune response in a natural manner represents an excellent prospect for disease prevention and treatment and is worthy of further research and development using approaches of modern science and technology.

show abstract

“…Based on previous report, a derivative of Astragali Radix has a therapeutic effect for myocardial injury by ameliorating the myocardial index content [11]. Moreover, Astragali Radix has been used as a nutrient supplement or immunomodulatory natural herbal medicine in health food for reinforcing physique and nourishing tissues [12].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology Study Reveals the Mechanism of Astragali Radix in Treatment of Diabetic Nephropathy

Tian¹,

Chen²,

Chen³

et al. 2020

Preprint

View full text Add to dashboard Cite

Background Diabetic nephropathy (DN), a unique complication of diabetes, could contribute to an increase in mortality. In this study, we predicted and proved the molecular pharmacological mechanism concerning the protective effects of Astragali Radix on DN. Methods The same potential target genes from Astragali Radix and DN were analyzed and constructed the protein interaction network. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment-related major targets and signal pathways were performed. The drug-ingredients-target-disease network was visually built using Cytoscape 3.6.1. The beneficial pharmacological activities of quercetin from Astragali Radix were confirmed by CCK-8 assay, determination of antioxidant parameters and Western blotting analysis. Results There are 12 bioactive components from Astragali Radix and 56 same targets between Astragali Radix and DN. The GO analysis results showed that the biological processes mainly included protein homodimerization activity. KEGG analysis indicate that the screened targets were most closely linked to the mitogen-activated protein kinase (MAPK) signaling pathway. The drug-ingredients-target-disease network results revealed that the therapeutic effects of Astragali Radix mainly included oxidative stress, inflammatory reaction and apoptosis. During the verification process, quercetin from Astragali Radix could attenuate cytotoxicity, enhance catalase (CAT) and superoxide dismutase (SOD) activities and suppress MAPK signaling pathway. Conclusions In the current study, network pharmacology with experimental analysis predicted and proved the therapeutic function of Astragali Radix by improving antioxidant capacity and suppressing MAPK signaling pathway, these investigations could provide a new perspective for further exploration of Astragali Radix on DN treatment.

show abstract

Astragali Radix (Huangqi): A promising edible immunomodulatory herbal medicine

Cited by 214 publications

References 117 publications

A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

A Network Pharmacology Approach to Explore the Potential Mechanisms of Yifei Sanjie Formula in Treating Pulmonary Fibrosis

Potential Application of Plant-Based Functional Foods in the Development of Immune Boosters

Network Pharmacology Study Reveals the Mechanism of Astragali Radix in Treatment of Diabetic Nephropathy

Contact Info

Product

Resources

About