Astragalus polysaccharide: a review of its immunomodulatory effect

Li, Chunxiao; Liu, Ying; Zhang, Yuzhen; Li, Jing-Chun; Lai, Jiang

doi:10.1007/s12272-022-01393-3

Cited by 124 publications

(59 citation statements)

References 189 publications

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“…Astragalus polysaccharide had a good regulation effect on metabolic pathway in DSS-induced colitis mice. 22 The mainly metabolic pathway was also lipid metabolism, including arachidonic acid metabolism, fatty acid synthesis, linoleic acid metabolism and glycerophosphatidic acid metabolism, which was similar to our results.…”

Section: Resultssupporting

confidence: 91%

Impact of purple sweet potato (Ipomoea batatas L.) polysaccharides on the fecal metabolome in a murine colitis model

et al. 2022

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Section: Resultssupporting

confidence: 91%

Impact of purple sweet potato (Ipomoea batatas L.) polysaccharides on the fecal metabolome in a murine colitis model

et al. 2022

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“…In addition, organic acid component, as the main active ingredient of pugongying, can improve acute tracheobronchitis by downregulating the protein expression levels of TNF-α and IL-6 (Yang et al, 2016). The main chemical constituents of Fuping, the flavones apigenin and luteolin, can suppress inflammatory responses by mediating neutrophil apoptosis (Lucas et al, 2013); In addition, Cangshu, Zhizi, and Huangqi have also been confirmed to have anti-inflammatory and anti-oxidant effects (Xiao et al, 2017;Kulma et al, 2021;Li et al, 2022). Combined with the aforementioned results, it may be suggested that PPQH plays an anti-SASR-COV-2 effect through its antiviral and anti-inflammatory cytokine storm functions; however, further research is still needed.…”

Section: Discussionmentioning

confidence: 99%

A retrospective study of Pupingqinghua prescription versus Lianhuaqingwen in Chinese participants infected with SARS-CoV-2 Omicron variants

Dong

Zhai²,

Fang³

et al. 2022

Front. Pharmacol.

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Background: Coronavirus disease (COVID-19) seriously endangers global public health. Pupingqinghua prescription (PPQH) is an herbal formula from traditional Chinese medicine used for treatment of SARS-CoV-2 infection. This study aims to evaluate the clinical efficacy and safety of PPQH in Chinese participants infected with the SARS-CoV-2 Omicron variant.Methods: A total of 873 SARS-CoV-2 (Omicron)-infected patients were included. Among them, the patients were divided into the PPQH group (653 cases) and LHQW group (220 cases) according to different medications. The effectiveness indicators (hematological indicators, Ct values of novel Coronavirus nucleic acid tests, and viral load-shedding time) and safety indicators (liver and kidney function and adverse events) were analyzed.Results: There was no significant difference in baseline characteristics between the PPQH group and the LHQW group, except the gender; After the treatment, the levels of IL-5, IL-6, IL-10, NK cells, and INF-α of the patients in the PPQH group showed a downward trend (p < 0.05); The viral load shedding time was 5.0 (5.0, 7.0) in the PPQH group and 5.0 (4.0, 7.0) in the LHQW group; both PPQH and LHQW can shorten the duration of symptoms of fever, cough, and sore throat. The re-positive rate of COVID-19 test was 1.5 % in the PPQH group and 2.3 % in the LHQW group. In terms of safety, the levels of γ-GTT decreased significantly (p < 0.01); gastrointestinal reaction was the primary adverse reaction, and the reaction rate was 4.7 % in the PPQH group and 9.5 % in the LHQW group.Conclusion: PPQH can shorten the length of hospital stay and improve clinical symptoms of patients with SARS-COV-2 (Omicron), and it also has a good safety profile.

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“…Furthermore, A. membranaceus polysaccharide can up-regulate peripheral blood IFN-γ, TNF-α, and IL-2 expression levels, and together with 5-FU, A. membranaceus polysaccharide, can enhance anti-tumor activity, where 5-FU is an immunosuppressive agent which can be used as an immune adjuvant for chemotherapy. A. membranaceus polysaccharides can also enhance the activity of dendritic cells, macrophages, natural killer cells, T and B lymphocytes, and microglia, as well as activating the expression of various cytokines and chemokines [147].…”

Section: Immune Response Promotionmentioning

confidence: 99%

Polysaccharides from Chinese herbs as natural weapons against colorectal cancer

et al. 2023

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Colorectal cancer (CRC) ranks third and second among the most widespread cancers worldwide and the most common causes of human death due to cancer, respectively. Further, for unknown reasons, numbers of young patients diagnosed with colon cancer has increased. Polysaccharides are important functional phytochemicals reported to have anti-CRC effects. Moreover, CRC development and progression is closely related to the gut microbiome. Although approaches for treating CRC have been the subject of some review papers, research into traditional Chinese medicine (TCM) treatments for CRC and the underlying mechanisms involving polysaccharides have not been reviewed. Here, we reviewed the mechanisms underlying treatment of CRC using TCM polysaccharides, based on the etiology of CRC, and common treatment methods applied. The relationship between intestinal microbes and CRC, the mechanism by which TCM polysaccharides induce CRC cell apoptosis, and how TCM polysaccharides promote immune responses are discussed, as well as TCM polysaccharide use in combination with chemotherapy. TCM polysaccharides provide options for CRC treatment, due to their advantages of having multiple targets, eliciting modest adverse reactions, and wide range of available sources.

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Astragalus polysaccharide: a review of its immunomodulatory effect

Cited by 124 publications

References 189 publications

Impact of purple sweet potato (Ipomoea batatas L.) polysaccharides on the fecal metabolome in a murine colitis model

Impact of purple sweet potato (Ipomoea batatas L.) polysaccharides on the fecal metabolome in a murine colitis model

A retrospective study of Pupingqinghua prescription versus Lianhuaqingwen in Chinese participants infected with SARS-CoV-2 Omicron variants

Polysaccharides from Chinese herbs as natural weapons against colorectal cancer

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