Astrocyte-induced positive integrated information in neuron-astrocyte ensembles

Kanakov, Oleg; Gordleeva, Susanna; Ermolaeva, Anastasia; Jalan, Sarika; Zaikin, Alexey

doi:10.1103/physreve.99.012418

Cited by 37 publications

(50 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Intense modeling efforts have been devoted in recent years to understand the functional role of astrocytic modulation of the neuronal communication (see Oschmann et al, 2018 for a recent review, Kanakov et al, 2019). There are several biophysical studies of astrocytic influence on post- and presynaptic neuronal activity (De Pittà et al, 2011; Gordleeva et al, 2012; Tewari and Majumdar, 2012a,b; Tewari and Parpura, 2013; De Pittà and Brunel, 2016; Flanagan et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

et al. 2019

View full text Add to dashboard Cite

The functional role of astrocyte calcium signaling in brain information processing was intensely debated in recent decades. This interest was motivated by high resolution imaging techniques showing highly developed structure of distal astrocyte processes. Another point was the evidence of bi-directional astrocytic regulation of neuronal activity. To analyze the effects of interplay of calcium signals in processes and in soma mediating correlations between local signals and the cell-level response of the astrocyte we proposed spatially extended model of the astrocyte calcium dynamics. Specifically, we investigated how spatiotemporal properties of Ca 2+ dynamics in spatially extended astrocyte model can coordinate (e.g., synchronize) networks of neurons and synapses.

show abstract

Section: Introductionmentioning

confidence: 99%

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The role of spatiotemporal patterns of astrocytic Ca 2+ activity has recently started to be appreciated (Kanakov et al, 2019;Semyanov, 2008;Semyanov, 2019). Individual Ca 2+ transients can trigger the local release of gliotransmitters (Zorec et al, 2012) or change the local synaptic microenvironment (e.g., by retracting or extending perisynaptic processes) (Tanaka et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

An astrocytic basis of caloric restriction action on the brain plasticity

Plata¹,

Popov

Denisov³

et al. 2019

Preprint

View full text Add to dashboard Cite

One month of calorically restricted diet (CR) induced morphological plasticity of astrocytes in the stratum (str.) radiatum of hippocampal CA1 in three-months old mice: the volume fraction of distal perisynaptic astrocytic processes increased whereas the number of gapjunction coupled astrocytes decreased. The uncoupling was not associated with a decrease in the expression of connexin 43. Uncoupling and morphological remodeling affected spontaneous Ca 2+ activity in the astrocytic network: Ca 2+ events became longer, whereas their spread was reduced. The change in the pattern of astrocytic Ca 2+ activity may increase the spatial resolution of the information encoding in the astroglial network. Consistent with expanded synaptic enwrapping by the astroglial processes, the spillover of synaptically released K + and glutamate was diminished after CR. However, no significant changes in the expression of astrocytic glutamate transporter (GLT-1/EAAT2) were observed, although the level of glutamine synthetase was decreased. Glutamate uptake is known to regulate the synaptic plasticity. Indeed, the magnitude of long-term potentiation (LTP) in the glutamatergic CA3-CA1 synapses was significantly enhanced after CR. Our findings highlight an astroglial basis for improved learning and memory reported in various species subjected to CR.

show abstract

“…Despite efforts in recent years to model the role of astrocytes in information processing in the CNS (Oschmann et al, 2018;Kanakov et al, 2019), only a few computational models are investigating the role of astrocytes in neurodegenerative diseases. The most popular pathological behavior of astrocytes investigated by modeling is epilepsy (Ullah et al, 2009;Volman et al, 2012;Amiri et al, 2013;Tewari and Parpura, 2013) and AD (Lenk et al, 2016).…”

Section: Applications To Age-related Diseasesmentioning

confidence: 99%

The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging

Whitwell

Bacalini

Blyuss

et al. 2020

Front. Aging Neurosci.

Self Cite

View full text Add to dashboard Cite

Biological aging is a complex process involving multiple biological processes. These can be understood theoretically though considering them as individual networks-e.g., epigenetic networks, cell-cell networks (such as astroglial networks), and population genetics. Mathematical modeling allows the combination of such networks so that they may be studied in unison, to better understand how the so-called "seven pillars of aging" combine and to generate hypothesis for treating aging as a condition at relatively early biological ages. In this review, we consider how recent progression in mathematical modeling can be utilized to investigate aging, particularly in, but not exclusive to, the context of degenerative neuronal disease. We also consider how the latest techniques for generating biomarker models for disease prediction, such as longitudinal analysis and parenclitic analysis can be applied to as both biomarker platforms for aging, as well as to better understand the inescapable condition. This review is written by a highly diverse and multidisciplinary team of scientists from across the globe and calls for greater collaboration between diverse fields of research.

show abstract

Astrocyte-induced positive integrated information in neuron-astrocyte ensembles

Cited by 37 publications

References 38 publications

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

Astrocyte as Spatiotemporal Integrating Detector of Neuronal Activity

An astrocytic basis of caloric restriction action on the brain plasticity

The Human Body as a Super Network: Digital Methods to Analyze the Propagation of Aging

Contact Info

Product

Resources

About